MCT1 is a proton-linked transport carrier that catalyzes the movement of short chain monocarboxylates (branched-chain oxo acids derived from leucine, valine, and isoleucine) across both plasma and inner mitochondrial membranes. In particular, substances such as lactate, pyruvate, butyrate, and ketone bodies are shuttled; these play big roles in cell metabolism particularly in tissues and organs like the kidney, intestine, liver, and brain.
Immunohistochemistry-Paraffin: Monocarboxylic acid transporter 1 Antibody [NBP1-59656] - IHC staining with Monocarboxylic acid transporter 1 antibody. Strong staining of lumen and crypt cells was observed with weaker cytoplasmic staining observed in the submucosa of mouse intestine.
Halestrap from the University of Bristol reviews the family of MCTs and their biochemical, three-dimensional structures, and regulation (1). Vijay et al focused their review on summarizing the physiological role of MCTs, their utility as brain drug delivery targets, and their influence on drug pharmacokinetics as they are also able to transport exogenous drugs such as salicylic acid, valproic acid, and simvastatin acid (2). A very recent 2015 review from Bergersen details the localization and function of MCTs in the brain, with an emphasis on understanding lactate transport and downstream signaling, and its effects on body-brain interactions during high blood lactate levels like those resulting from physical exercise (3). Swiss researchers used the MCT1 antibody in their MCT1-deficient knockout mouse system to assess the role of MCT1 in energy homeostasis and balance (4). Their results indicate a variety of metabolic perturbations including a resistance to diet-induced obesity and insulin resistance.
Novus Biologicals offers MCT1 reagents for your research needs including:
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