ACBP Products

Description

ACBP encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. ACBP is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Bioinformatics

Entrez	1622 Human
Uniprot	NM_020548 Human NP_001073331 Human NP_065438 Human NP_065438.1 Human P07108 Human
Product By Gene ID	1622
Alternate Names	acyl-Coenzyme A binding domain containing 1 acyl-Coenzyme A bindingprotein) CCK-RP cholecystokinin-releasing peptide, trypsin-sensitive diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) Diazepam-binding inhibitor endozepine Endozepine EP GABA receptor modulator MGC70414

Research Areas for ACBP

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Cancer