Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Bt, Ca, Eq, Pm, Pm, Pm, Rb, Sh
Applications: ELISA, Flow, IHC
Host: Goat Polyclonal
Species: Hu
Applications: Flow
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
7305 |
| Alternate Names |
- DAP12PLOSL
- DNAX-activation protein 12
- KARAPPLO-SL
- KAR-associated protein
- killer activating receptor associated protein
- Killer-activating receptor-associated protein
- TYRO protein tyrosine kinase binding protein
- TYRO protein tyrosine kinase-binding protein
|
Research Areas for DAP12
Find related products by research area and learn more about each of the different research areas below.
ApoptosisSignal Transduction
![Intracellular Staining by Flow Cytometry DAP12 Antibody (406209) [Unconjugated]](http://images.novusbio.com/fullsize2/mab52401_human-dap12-mab-clone-406209-intracellular-staining-by-flow-cytometry-268202215198.jpg)
