Species: Hu
Applications: WB, Flow, B/N, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, B/N
Host: Goat Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Binding Activity
Species: Hu
Applications: Bioactivity
Description
CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
10666 |
| Alternate Names |
- CD226 antigenplatelet and T cell activation antigen 1
- CD226 molecule
- DNAM1adhesion glycoprotein
- DNAM-1DNAX accessory molecule-1
- DNAX accessory molecule 1
- PTA1
- T lineage-specific activation antigen 1 antigen
- TLiSA1
|
![Flow Cytometry DNAM-1/CD226 Antibody (102511) [Unconjugated]](http://images.novusbio.com/fullsize2/DNAM1_MAB666_Flow_Cytometry_19202.jpg)
![Neutralization DNAM-1/CD226 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/DNAM-1_AF666_Block_Neutralize_8941.jpg)
![N/A DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize2/dy666-05_human-dnam-1-cd226-duoset-elisa-5-plate-3182021134227.jpg)
![Binding Activity DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize2/DNAM1_AVI9298_2673.jpg)
![Bioactivity DNAM-1/CD226 [Unconjugated]](http://images.novusbio.com/fullsize2/DNAM1_4436DN_1290.jpg)
![Binding Activity DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize2/DNAM1_AVI666_2770.jpg)
![Neutralization DNAM-1/CD226 Antibody (102511) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab666_human-dnam-1-cd226-mab-clone-102511-neutralization-59202414937.jpg)
![SDS-PAGE DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize2/DNAM1_AVI9298_2500.jpg)
![SDS-PAGE DNAM-1/CD226 [Biotin]](http://images.novusbio.com/fullsize2/DNAM1_AVI666_2649.jpg)