eIF2A Products

Description

The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM]

Bioinformatics

Entrez	229317 Mouse 502531 Rat 83939 Human
Uniprot	AAH11885.1 Human NM_032025 Human NP_004085 Human NP_114414 Human P05198 Human
Product By Gene ID	83939
Alternate Names	EIF-2 EIF-2A EIF2AEIF2 EIF-2alpha eIF-2alpha eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa subunit 1 (alpha, 35kD )

Research Areas for eIF2A

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research
DNA Repair
Lipid and Metabolism
Phospho-Specific
Translation Control
Unfolded Protein Response

Related eIF2A Blog Posts

Check out the latest blog posts on eIF2A.

PKR - Mediating cellular stress responses through multiple signaling pathways Protein kinase R (PKR) is an intracellular stress-sensing protein that is able to detect and respond to viral infections. While PKR is able to sense and respond to a variety of signals, dsRNA is a well-characterized ligand. dsRNA produced during v...    Read more.

eIF2alpha - a regulator of global translation in response to cellular stress Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...    Read more.

Read more eIF2A related blogs.