ELAC2 Products

Description

The protein encoded by the ELAC2 gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity,which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activatedSmad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expressioncan suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased riskof prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq)

Bioinformatics

Entrez	60528 Human
Uniprot	NM_018127 Human NP_060597 Human Q9BQ52 Human
Product By Gene ID	60528
Alternate Names	EC 3.1.26.11 elaC homolog 2 (E. coli) ElaC homolog protein 2 ELC2 FLJ10530 FLJ36693 FLJ42848 Heredity prostate cancer protein 2 HPC2elaC (E. coli) homolog 2 putative prostate cancer susceptibility protein HPC2/ELAC2 Ribonuclease Z 2 RNase Z 2 tRNA 3 endonuclease 2 tRNase Z (long form) tRNase Z 2 zinc phosphodiesterase ELAC protein 2