Hemoglobin A1 Products

Description

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

Bioinformatics

Entrez	15122 Mouse 25632 Rat 3039 Human
Uniprot	NM_000558 Human NP_000549 Human P69905 Human
Product By Gene ID	3039
Alternate Names	alpha one globin alpha-1 globin alpha-1-globin alpha-globin Alpha-globin CD31 hemoglobin alpha 1 globin chain Hemoglobin alpha chain hemoglobin alpha-1 chain hemoglobin subunit alpha hemoglobin, alpha 1 MGC126895 MGC126897

Research Areas for Hemoglobin A1

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Signal Transduction