HLA B Products

Description

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq]

Bioinformatics

Entrez	3106 Human
Uniprot	AAH13187 Human AAH13187.1 Human NM_005514 Human P01889 Human
Product By Gene ID	3106
Alternate Names	ankylosing spondylitis AS B'DT b'DT Bw-22 Bw-4 Bw-41 Bw-44 Bw-45 Bw-46 Bw-47 Bw-48 Bw-50 Bw-52 Bw-53 Bw-54 Bw-55 Bw-56 Bw-57 Bw-58 Bw-60 HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, B-12 alpha chain HLA class I histocompatibility antigen, B-21 alpha chain HLA class I histocompatibility antigen, B-5 alpha chain HLA class I histocompatibility antigen, B-7 alpha chain HLAB HLA-B27 HLA-B73 leukocyte antigen class I-B lymphocyte antigen major histocompatibility complex, class I, B MGC111087 MHC class I antigen B*13 MHC class I antigen B*14 MHC class I antigen B*15 MHC class I antigen B*18 MHC class I antigen B*27 MHC class I antigen B*35 MHC class I antigen B*37 MHC class I antigen B*38 MHC class I antigen B*39 MHC class I antigen B*40 MHC class I antigen B*41 MHC class I antigen B*42 MHC class I antigen B*44 MHC class I antigen B*45 MHC class I antigen B*46 MHC class I antigen B*47 MHC class I antigen B*48 MHC class I antigen B*49 MHC class I antigen B*50 MHC class I antigen B*51 MHC class I antigen B*52 MHC class I antigen B*53 MHC class I antigen B*54 MHC class I antigen B*55 MHC class I antigen B*56 MHC class I antigen B*57 MHC class I antigen B*58 MHC class I antigen B*59 MHC class I antigen B*67 MHC class I antigen B*7 MHC class I antigen B*73 MHC class I antigen B*78 MHC class I antigen B*8 MHC class I antigen B*81 MHC class I antigen B*82 MHC class I antigen GN00104 MHC class I antigen HLA-B heavy chain MHC class I antigen SHCHA MHC Class I HLA heavy chain MHC HLA-B cell surface glycoprotein SPDA1

Research Areas for HLA B

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology