HMW Kininogen Products

Description

High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]

Bioinformatics

Entrez	3827 Human
Uniprot	NM_000893 Human NP_000884 Human NP_000884.1 Human P01042 Human
Product By Gene ID	3827
Alternate Names	Alpha-2-thiol proteinase inhibitor BDK bradykinin Fitzgerald factor High molecular weight kininogen kininogen 1 kininogen kininogen-1 KNGHMWK Williams-Fitzgerald-Flaujeac factor

Research Areas for HMW Kininogen

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology