IkB-epsilon Products

Description

The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkappaB-alpha and specifically phosphorylates IkappaB-alpha on the sites that trigger its degradation, Serines 32 and 36. IKKalpha appears to be critical for NFkappaB activation in response to proinflammatory cytokines. Phosphorylation of IkappaB by IKKalpha is stimulated by the NFkappaB inducing kinase (NIK), which itself is a central regulator for NFkappaB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation.

Bioinformatics

Entrez	18037 Mouse 316241 Rat 4794 Human
Uniprot	NP_004547 Human O00221 Human
Product By Gene ID	4794
Alternate Names	epsilon ikappaBepsilon IkappaBepsilon I-kappa-B-epsilon IkB-E ikB-E IKBENF-kappa-B inhibitor epsilon ikB-epsilon IkB-epsilon NF-kappa-BIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Research Areas for IkB-epsilon

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Cancer
Phospho-Specific