Species: Hu
Applications: WB, ELISA, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Lactoferrin is an iron binding glycoprotein with an approximate molecular weight of 80 kDa. The protein has two iron binding domains each housing one Fe3+ and the synergistic CO32- ion. The crystal structure form of human lactoferrin at 2.2A resolution exhibits 5330 protein atoms, 2Fe2+, 2CO32- and 98 carbohydrate atoms. Lactoferrin is absorbed from intestine by apical side of the membrane and localized to the nuclei. Intravenous infusion of lactoferrin is protective against lethal doses of E coli and induce bacterimia by a mechanism that downregulates neutrophil TNF alfa secretion. Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated for use as a dietary supplement to treat iron deficiency and/or iron deficiency induced anemia. Lactoferrin has been shown to have a role in the immune system and in early development of the embryo. A specific receptor for lactoferrin binding has been implicated in the human fetal intestine. Early embryonic localisation of lactoferrin by IHC has suggested its presence in various tissues including intestinal epitheliuem, kiney, and various regions of the brain.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
4057 |
| Alternate Names |
- EC 3.4.21
- EC 3.4.21.-
- GIG12
- growth-inhibiting protein 12
- HLF2
- Lactoferrin
- lactotransferrin
- LF
- neutrophil lactoferrin
- talalactoferrin
- Talalactoferrin
|
Related Lactoferrin Blog Posts
Check out the latest blog posts on Lactoferrin.
Cyanine (Cy)
Cyanine dyes are members of the polymethine synthetic dye family historically used to increase photographic emulsion sensitivity. Cyanine dyes have versatile applications and are commonly used as fluorescent labels for proteins, nucleic acids, and sma... Read more.
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Read more Lactoferrin related blogs.
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