Species: Hu
Applications: WB, ICC/IF
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse monoclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Description
LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-225; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPAR 225. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity. A deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
23175 |
| Alternate Names |
- DKFZp781P1796
- EC 3.1.3.18
- EC 3.1.3.4
- EC 5.4.2.7
- KIAA0188phosphatidate phosphatase LPIN1
- lipin 1
- lipin-1
- Lipin-1
- PAP1
|
![Immunocytochemistry Lipin 1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Lipin_1_AF3885_Immunocytochemistry__Immunofluorescence_19732.jpg)
