Lymphotoxin beta/TNFSF3 Products

Description

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha, also known as TNF beta) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. LT-beta (lymphotaxin-beta or tumor necrosis factor C) is a type II membrane protein with significant homology to TNF, LT-alpha, and the ligand for the CD40 receptor. LT-alpha is present on the surface of activated T, B, and LAK cells as a complex with the 33 kda glycoprotein, LT-beta. LT-beta, also expressed by active lymphocytes, forms a heterotrimer with LT-a on the cell surface and anchors LT-alpha to the cell surface. A TNF receptor-related protein, the LT-beta receptor (also known as TNFC receptor), is the human receptor for the LT-alpha/LT-beta heterotrimer. There are two LT-beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. The gene which encodes LT-beta maps to the major histocompatibility complex region on human chromosome 6p21.3.

Bioinformatics

Entrez	16994 Mouse 4050 Human
Uniprot	BAC54938.1 Human Q06643 Human
Product By Gene ID	4050
Alternate Names	lymphotoxin beta (TNF superfamily, member 3) lymphotoxin-beta p33 TNFCTNF-C TNFSF3LT-beta Tumor necrosis factor C Tumor necrosis factor ligand superfamily member 3