Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Mouse Monoclonal
Species: Hu, Mu, Ca, Eq
Applications: WB, Simple Western, IP
Host: Rabbit Polyclonal
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Phosphofructokinases (PFK) are regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Human PFK-1 is tetrameric and isoenzymes include PFK-1 muscle (PFKM, PFK-A), PFK-1 liver (PFKL, PFK-B) and PFK-1 platelet (PFKP, PFK-C, PFKF). PFK-1 is inhibited by ATP and citrate (from the tricarboxylic acid cycle). PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose 2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose 2,6-bisphosphate and contains fructose 2,6-biphosphatase activity that catalyzes the degradation of fructose 2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
5213 |
| Alternate Names |
- 6-phosphofructokinase, muscle type
- EC 2.7.1,6-phosphofructo-1-kinase
- EC 2.7.1.11
- GSD7
- MGC8699
- PFK1
- PFK-1
- PFKA
- PFK-A
- PFKX
- Phosphofructo-1-kinase isozyme A
- Phosphofructokinase 1
- phosphofructokinase, muscle
- phosphofructokinase, polypeptide X
- phosphofructokinase-M
- Phosphofructokinase-M
- Phosphohexokinase
- phosphohexokinase
|
Research Areas for Muscle Phosphofructokinase/PFKM/PFK-1
Find related products by research area and learn more about each of the different research areas below.
Lipid and Metabolism
![Western Blot Muscle Phosphofructokinase/PFKM/PFK-1 Antibody (842735) [Unconjugated]](http://images.novusbio.com/fullsize2/Muscle_Phosphofructokinase_MAB7687_Western_Blot_12987.jpg)
![Simple Western Muscle Phosphofructokinase/PFKM/PFK-1 Antibody (842735) [Unconjugated]](http://images.novusbio.com/fullsize2/Muscle_Phosphofructokinase_MAB7687_Simple_Western_16532.jpg)
