Neurofibromin 1 Products

Description

Neurofibromin 1 (NF1) is a suspected negative regulator of the ras signal transduction pathway. Neurofibromin is known to regulate the GTPase HRAS, causing the hydrolyzation and inactivation of GTP. Defects in NF1 lead to Neurofibromatosis disease, Recklinghausen disease or Watson disease. Neurofibromin has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.

Bioinformatics

Uniprot	NP_000258 Human P21359 Human
Product By Gene ID	4763
Alternate Names	DKFZp686J1293 FLJ21220 Neurofibromatosis-related protein NF-1 neurofibromin 1 neurofibromin NFNS VRNF WSS

Research Areas for Neurofibromin 1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Chromatin Research
Cytoskeleton Markers
Hypoxia
Neuroscience
Neurotransmission
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors

Related Neurofibromin 1 Blog Posts

Check out the latest blog posts on Neurofibromin 1.

Developmental regulator Daam2 promotes glial cell tumors by degrading Von Hippel-Lindau protein By Jamshed Arslan Pharm.D. Glioblastoma is an aggressive type of cancer that forms from the star-shaped glial cells of the central nervous system, called astrocytes. Intriguingly, several genes linked to glioblasto...    Read more.

Neurofibromatosis Infographic Neurofibromatosis (NF) is a genetic disorder caused by mutations in the NF1, NF2 or SMARCB1 genes which lead to tumor growth on nerves throughout the body. Although the tumors are usually benign, they still require chemotherapy to shrink and may becom...    Read more.

Read more Neurofibromin 1 related blogs.