Protein Phosphatase inhibitor 1 Products

Description

The inhibitor of protein phosphatase 1 (IPP-1, I-1) is an endogenous inhibitor of protein phophastase 1 (PP-1), a signal transducer in many cellular pathways. IPP-1 is a member of heat-stable PP1 inhibitory subunits, which includes DARPP-32, (a homologue of IPP-1) and IPP-2. First discovered in rabbit skeletal muscle, IPP-1 is expressed in various mammalian tissues. IPP-1 inhibition of PP-1 is controlled through phosphorylation at Thr35 by cAMP-dependent protein kinase and a tetra-peptide consensus motif in various PP-1 binding proteins (1). IPP-1 is a hormonal control in muscle contraction, pituitary cell growth, synaptic plasticity by neurotransmitters, and glycogen metabolism (2). In vivo, IPP-1 is phosphorylated at Ser-67 by NCLK, which also initiates inhibition of PP-1 by IPP-1 (3). Triggered by increase in calcium level, IPP-1 is inactivated by PP2B through de-phosphorylation (4).

Bioinformatics

Entrez	5502 Human 58200 Mouse 58977 Rat
Uniprot	AAH22470 Human NM_006741 Human Q13522 Human
Product By Gene ID	5502
Alternate Names	I1 I-1 IPP-1 IPP1inhibitor-1 protein phosphatase 1 regulatory subunit 1A protein phosphatase 1, regulatory (inhibitor) subunit 1A Protein phosphatase inhibitor 1 protein phosphatase inhibitor-1