Sodium Potassium ATPase Alpha 3 Products

Description

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.

Bioinformatics

Entrez	232975 Mouse 24213 Rat 478 Human
Uniprot	NM_152296 Human NP_689509.1 Human P13637 Human
Product By Gene ID	478
Alternate Names	alpha 3 polypeptide ATPase, Na+/K+ transporting, alpha 3 polypeptide dystonia 12 DYT12 EC 3.6.3 MGC13276 RDP Sodium pump subunit alpha-3 sodium/potassium-transporting ATPase alpha-3 chain sodium/potassium-transporting ATPase subunit alpha-3