TAB2 Products

Description

TAB2 is encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq]

Bioinformatics

Entrez	23118 Human
Uniprot	NM_015093 Human NP_055908 Human NP_055908.1 Human Q9NYJ8 Human
Product By Gene ID	23118
Alternate Names	FLJ21885 KIAA0733CHTD2 MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2 Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 TAB-2 TAK1-binding protein 2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1-binding protein 2

Research Areas for TAB2

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Signal Transduction