TAO2 Products

Description

In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.

Bioinformatics

Entrez	64666 Rat 9344 Human
Uniprot	AAH51798 Human NM_004783 Human NP_057235 Human Q9UL54 Human
Product By Gene ID	9344
Alternate Names	EC 2.7.11 KIAA0881PSK-1 Kinase from chicken homolog C MAP3K17PSK1-BETA Prostate-derived STE20-like kinase 1 PSK1EC 2.7.11.1 PSKhKFC-C serine/threonine-protein kinase TAO2 TAO kinase 2 TAO1 TAO2prostate derived STE20-like kinase PSK Thousand and one amino acid protein 2 thousand and one amino acid protein kinase

Research Areas for TAO2

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Apoptosis
Phospho-Specific