TRADD Products

Description

TRADD [tumor necrosis factor receptor type 1-associated (TNFR1) death domain protein] is a death domain containing adaptor molecule that interacts with TNFR1/TNFRSF1A and mediates programmed cell death signaling and NF-kB activation (reviewed in Feng, 2005). TRADD binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thereby suppresses TRAF2 mediated apoptosis. TRADD can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. This antibody recognizes TRADD; human TRADD is a 312 amino acid protein.

Bioinformatics

Entrez	71609 Mouse 8717 Human
Uniprot	NM_003789 Human NP_003780 Human NP_003780.1 Human Q15628 Human
Product By Gene ID	8717
Alternate Names	MGC11078 TNFRSF1A-associated via death domainTNFR1-associated DEATH domain protein tumor necrosis factor receptor type 1 associated death domain protein tumor necrosis factor receptor type 1-associated DEATH domain protein tumor necrosis factor receptor-1-associated protein

Research Areas for TRADD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

Related TRADD Blog Posts

Check out the latest blog posts on TRADD.

Caspase 9: The Suicidal Cell Whisperer Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include ...    Read more.

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