17-AAG

Product Image: 17-AAG [NB110-81558] - Chemical structure of 17-AAG (NB110-81558), a 17-AAG. Molecular Formula: C31H43N3O8. Molecular Weight: 585.7 g/mol.

• Applications: Func, NULL

17-AAG Summary

• Description: Hsp90 inhibitor. Molecular Formula C31H43N3O8. Molecular weight 585.7 g/mol. CAS No. 75747-14-7
• Specificity: 17-AAG Compound

Applications/Dilutions

• Dilutions:
  • Adhesion Activation
  • Product Image
• Application Notes: Soluble in DMSO (>50 mg/mL) or ethanol (5 mg/mL)

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.

Background

Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.