ADAM19 Antibody (164646)

• Reactivity: Mu
• Applications: WB
• Clone: 164646
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

ADAM19 Antibody (164646) Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM19 Ectodomain
  Asp205-Gly705 (predicted)
  Accession # O35674
• Marker: Dendritic Cell Marker
• Specificity: Detects mouse ADAM19 Ectodomain in direct ELISAs and Western blots. It also recognizes a C-terminal fragment (amino acids 588‑705) of recombinant mouse (rm) ADAM19 in Western blots. In Western blots, no cross-reactivity with rmADAM10 or rmADAM15 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: ADAM19
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ADAM19 Antibody (164646)

• a disintegrin and metalloproteinase domain 19 (meltrin beta)
• ADAM 19
• ADAM metallopeptidase domain 19
• ADAM19
• disintegrin and metalloproteinase domain-containing protein 19
• EC 3.4.24
• EC 3.4.24.-
• MADDAM
• Meltrin beta
• meltrin-beta
• Metalloprotease and disintegrin dendritic antigen marker
• MLTNBmeltrin beta

Background

ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta ) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to alpha 2-Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin beta chain, TNF-alpha , TRANCE and SCF. Over amino acids (aa) 205‑705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADAM19
• Uniprot:
  • O35674()