ADAMTS4 Antibody

Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP3-06665] - ADAMTS4 Antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry: ADAMTS4 Antibody [NBP3-06665] - IHC analysis of Brain, Glioblastoma

Immunohistochemistry: ADAMTS4 Antibody [NBP3-06665] - IHC analysis of Breast, Carcinoma

Immunohistochemistry: ADAMTS4 Antibody [NBP3-06665] - IHC analysis of Lung, Non Small-Cell Carcinoma

Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP3-06665] - ADAMTS4 Antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP3-06665] - ADAMTS4 Antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

ADAMTS4 Antibody Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from Metalloprotease domain of human ADAMTS4.
• Epitope: Metalloprotease domain
• Specificity: Human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (94%), Orangutan (100%), Primate (100%), Equine (100%), Monkey (100%), Bat (100%), Canine (100%). Backed by our 100% Guarantee.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADAMTS4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4 ug/ml

Reactivity Notes

Gibbon (100%), Marmoset (100%), Rat (81%), Bovine (81%), Opossum (81%)

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 0.3 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ADAMTS4 Antibody

• a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4
• ADAM metallopeptidase with thrombospondin type 1 motif, 4
• ADAM-TS 4
• ADAMTS-2
• ADAMTS4
• ADAM-TS4
• ADAMTS-4
• ADMP-1
• ADMP-1EC 3.4.24.82
• Aggrecanase 1
• aggrecanase-1
• EC 3.4.24
• KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4

Background

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. ADAMTS4 expression has been documented in normal human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADAMTS4