APE Full Length Recombinant Protein

Product Discontinued

APE Full Length Recombinant Protein Summary

• Description: A full-length recombinant protein corresponding to APEX1.
• Protein/Peptide Type: Full Length Recombinant Protein
• Gene: APEX1
• Purity: Protein

Applications/Dilutions

Publications

Read Publications using NB100-101PEP.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Protein is dissolved in dH2O. Contains no BSA.
• Preservative: No Preservative
• Purity: Protein

Alternate Names for APE Full Length Recombinant Protein

• AP endonuclease 1
• APE
• APE1
• APE-1
• APEAPEX nuclease (multifunctional DNA repair enzyme)
• APENAP endonuclease class I
• APEX deoxyribonuclease (apurinic or apyrimidinic)
• APEX nuclease (multifunctional DNA repair enzyme) 1
• APEX nuclease
• APEX1
• Apurinic-apyrimidinic endonuclease 1
• APXAP lyase
• DNA-(apurinic or apyrimidinic site) lyase
• EC 3.1
• EC 4.2.99.18
• HAP1apurinic/apyrimidinic (abasic) endonuclease
• multifunctional DNA repair enzyme
• protein REF-1
• redox factor 1
• Redox factor-1
• REF1 apurinic/apyrimidinic exonuclease
• REF-1

Background

The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for APE Protein (NB100-101PEP)(9)

Publications using NB100-101PEP

• Tanaka M, Takahara M, Nukina K et al. Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase. Cell Cycle. 2017-02-22 [PMID: 28278049]
• Fujimura, M et al. Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 30(11):2408-15. 1999-11-01 [PMID: 10548678]
• Morita-Fujimura, Y et al. Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice. Neuroscience 93(4):1465-73. 1999-01-01 [PMID: 10501471]
• Kawase, M et al. Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis. Stroke 30(2):441-8; discussion 449. 1999-02-01 [PMID: 9933285]
• Xu, Y et al. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Res 17(5B):3713-19. 1997-09-01 [PMID: 9427767]
• Robertson, K A et al. Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells. Cell Growth Differ 8(4):443-9. 1997-04-01 [PMID: 9101090]
• Xanthoudakis, S Curran, T. Redox regulation of AP-1: a link between transcription factor signaling and DNA repair. Adv Exp Med Biol 387:69-75. 1996-01-01 [PMID: 8794196]
• Wilson, TM et al. Differential expression of the apurinic / apyrimidinic endonuclease (APE/ref-1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis. Mutat Res 362(3):237-48. 1996-04-02 [PMID: 8637502]
• Duguid, J R, Eble, J N, Wilson, T M, Kelley, M R. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res 55(24):6097-102. 1995-12-15 [PMID: 8521399]

Bioinformatics

• Gene Symbol: APEX1