beta-2 Adrenergic R/ADRB2 Antibody

Western Blot: beta-2 Adrenergic R/ADRB2 Antibody [H00000154-B01P] - Analysis of ADRB2 expression in transfected 293T cell line by ADRB2 polyclonal antibody. Lane 1: ADRB2 transfected lysate(45.43 KDa). Lane 2: Non-transfected lysate.

Flow Cytometry: beta-2 Adrenergic R/ADRB2 Antibody [H00000154-B01P] - Analysis of negative control 293 cells (Black) and ADRB2 expressing 293 cells (Green) using ADRB2 purified MaxPab mouse polyclonal antibody.

Product Discontinued

beta-2 Adrenergic R/ADRB2 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: ADRB2 (NP_000015, 1 a.a. - 413 a.a.) full-length human protein. MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
• Specificity: ADRB2 - adrenergic, beta-2-, receptor, surface,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: ADRB2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control. It has been use for FACS.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody

• ADRB2
• ADRB2R
• ADRBR
• adrenergic, beta-2-, receptor, surface
• B2AR
• B2ARADRB2R
• BAR
• beta-2 Adrenergic R
• beta-2 adrenergic receptor
• beta2 AdrenergicR
• beta-2 AdrenergicR
• Beta-2 adrenoceptor
• Beta-2 adrenoreceptor
• BETA2AR
• catecholamine receptor

Background

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for beta-2 Adrenergic R/ADRB2 Antibody (H00000154-B01P)(2)

Publications using H00000154-B01P

• Hudson BD, Kelly ME. Identification of Novel Competing b2AR Phospho-Extracellular Signal Regulated Kinase 1/2 Signaling Pathways in Human Trabecular Meshwork Cells. J Ocul Pharmacol Ther. 2011-10-03 [PMID: 22010988]
• Lencesova L, Sirova M, Csaderova L et al. Changes and role of adrenoceptors in PC12 cells after phenylephrine administration and apoptosis induction. Neurochem Int;57(8):884-92. 2010-12-01 [PMID: 20888879]

Bioinformatics

• Gene Symbol: ADRB2
• Entrez:
  • 154(Human)
• Uniprot:
  • NP_000015()