beta-Actin Antibody (AC-15)

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - MCDK cells induced with C22H24N2O8 to control the expression of the gene of interest. Beta-actin blocking confirms the albumin assay showing that an equal amount of lysate was loaded in each lane.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Beta-Actin expression in Fibroblast Hs68 cell lysate using anti-beta-Actin antibody. Image from verified customer review.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Cell line lysates were separated on SDS-PAGE and probed with 1:5000 Monoclonal Anti-beta-Actin Clone: AC-15 . The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate.Lanes: 1. HeLa, 2. JURKAT, 3. COS7, 4. NIH-3T3, 5. PC-12, 6. RAT2, 7.CHO, 8. MDBK, 9. MDCK

Immunocytochemistry/Immunofluorescence: beta-Actin Antibody (AC-15) [NB600-501] - Analysis of beta-Actin antibody on mouse fibroblasts. Image from verified customer review.

Immunohistochemistry: beta-Actin Antibody (AC-15) [NB600-501] - Staining of formalin-fixed, paraffin-embedded human heart sections with 1:1000 Monoclonal Anti-beta-Actin Clone: AC-15.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Analysis of beta-Actin in bovine whole skeletal muscle lysate. Image from verified customer review.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Whole cell extract of human fibroblasts was separated on SDS-PAGE and blotted with Monoclonal Anti-beta-Actin. The antibody was developed with Goat Anti-Mouse IgG, Peroxidase conjugate and AEC substrate. Lanes A: Antibody dilution 1:5,000 B: Negative control (only secondary antibody).

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - beta-Actin expression in human glioma cells using anti-beta-Actin antibody. Image from verified customer review.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - HEK293T cells transfected with Niaph virus Matrix Protein, expression 24h later. This image was submitted via customer review.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - MMP-11 expression in oral cancer cell lines and the MMP-11 knockdown in SCC9 cells reduce cell migration. Western blot analysis showing the expression of MMP-11 protein in five oral cancer cell lines. Beta-Actin is included as a loading control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0113129), licensed under a CC-BY license.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - HSP90 and HSP70 interact with PABPN1. Interaction of PABPN1 with HSP90. Lysates from HEK293 cells transfected with Flag-HSP90 and GFP-tagged A17-PABPN1 were immunoprecipitated with an anti-Flag antibody. Immunoprecipitates (IP) were analyzed by Western blot (IB).Beta-Actin is included as a loading control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0138936), licensed under a CC-BY license.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - GFAP and IL-6 are elevated in cultures of spinal cord compared to cortical astrocytes. ((G, H) Analysis of protein homogenates from brain or spinal cord astrocyte cultures also demonstrated higher levels of GFAP expression, but no differences in ALDH1L1. Beta-Actin is included as a loading control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0180697), licensed under a CC-BY license.

Immunocytochemistry/Immunofluorescence: beta-Actin Antibody (AC-15) [NB600-501] - Cultured FS-11 human fibroblast cell line stained using Monoclonal Anti-Beta-Actin, Clone No. AC-15 (NB600-501).

Immunocytochemistry/Immunofluorescence: beta-Actin Antibody (AC-15) [NB600-501] - HS-68 cells.

Simple Western: beta-Actin Antibody (AC-15) [NB600-501] - Analysis using the HRP conjugate of NB600-501. Electropherogram image(s) of corresponding Simple Western lane view. Beta-Actin antibody was used at 1:500 dilution on Hela, MCF-7, SH-SY5Y, & Jurkat lysate(s).

Simple Western: beta-Actin Antibody (AC-15) [NB600-501] - Analysis using the HRP conjugate of NB600-501. Image shows a specific band for Beta-Actin in 0.2 mg/mL of Hela, MCF-7, SH-SY5Y, & Jurkat lysate(s). This experiment was performed under reducing conditions using the 12-230 kDa separation system. * Non-specific interaction with the 230 kDa Simple Western standard may be seen with this antibody.

VPA reduces autophagy at P28. (A) Schematic of VPA administration. (B) Representative Western blot images for LC3B, p62, p-rpS6 S240/244, DARPP32, & actin. (B–G) Quantification of (B–D) p-rpS6 S240/244 relative to actin, (B,E,F) LC3B-ii relative to actin (B,G,H) p62 & (B,I,J) DARPP32 normalized to VPA untreated (veh, vehicle) mice at P10 & P28, respectively. Data analyzed with unpaired, two-tailed t-test; (C) p-rpS6 S240/244/actin at P10, ns; (D) p-rpS6 S240/244/actin at P28, t11 = 2.882, p = 0.0149 (E) LC3B-ii/actin at P10, ns; (F) LC3B-ii/actin at P28, t10 = 2.231, p = 0.047; (G) p62 at P10, ns; (H) p62 at P28, t10 = 3.752, p = 0.0038; (I) DARPP32 at P10, ns, & (J) DARPP32 at P10, ns, *p 0.05). ns = not significant. Image collected & cropped by CiteAb from the following publication (//www.oncotarget.com/lookup/doi/10.18632/oncotarget.21145), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effect of IFN-gamma pretreatment on carfilzomib sensitivity of H727 (a) & H23 (b) cells. IFN-gamma (150 U⋅ml−1) pretreatment for 24 h led to increased expression (left panel) & activity (middle panel) of proteasome immuno-subunits, & sensitized H727 cells to Cfz, while desensitizing H23 cells towards Cfz. The IC50 values displayed a statistically significant difference between IFN-gamma -pretreated cells & vehicle control (P value 0.1, n = 3). (c) Immunoblotting results showing no detectable expression of P-glycoprotein (P-gp) in H727 cells. DLD-1 cells with acquired Cfz resistance via P-gp upregulation (DLD-1/CfzR) were used as a positive control. (d) The co-treatment of reversin-121 (7.5 µM, P-gp inhibitor) did not affect the sensitivity of H727 cells to Cfz. The IC50 values did not show statistically significant difference between in the presence & absence of reversin-121 (Student’s t-test). (e) The levels of remaining Cfz in culture media were comparable between H727 & H23 cells (no statistically significant differences, t-tests the Holm-Sidak method to correct for multiple comparisons with alpha = 0.05). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30858500), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - (a) Immunoblots showing the expression of cP & iP catalytic subunits in H727 & H23 cells. Immunoblots for additional cell lines displaying differential expression of proteasome catalytic subunits are presented in Supplementary Fig. S2. (b) Heat map displaying differential proteasome activity profiles in H727 & H23 cell lines. Purified human 20S cP & iP were used as controls for individual subunits: 20S cP for beta 5 & beta 1 & 20S iP for beta 5i & beta 1i. The numbers represent hydrolysis rates of respective substrates (RFU/min, mean values derived from three technical replicates) & were converted to color format & clustered by using the program “R” (//www.R-project.org). (c) Remaining catalytic activities of individual proteasome subunits in H727 & H23 cells 4 h after treatment with 20 nM of carfilzomib (left panel) or 20 nM bortezomib (right panel). Data are presented as mean ± SD derived from three technical replicates. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30858500), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effects of insulin on AKT & ERK phosphorylation & cell viability in primary human pancreatic duct cells. Phosphorylated AKT & ERK were measured in primary pancreatic exocrine cultures treated with the indicated concentrations of insulin for 5 minutes (A, B) & 24 hours (C, D) (n =3-4) Fold refers to the fold change of sample relative to control at the same time point. (E) Quantification of automated cell-counting studies employing live-cell imaging of Hoechst-labeled cell cultures over 60 hours. (n =3). (F) Quantification of proliferation by BrdU staining of treated relative to untreated over 3 days (n =4). (G) Quantification of the average number of dying/dead treated cells, propidium iodide (PI) labeled, over 60 hours relative to non-treated cells. (n =3). (H) Human exocrine cells were exposed to 0, 0.2, 2, 20, 200 nM insulin for 3 days. Bright-field images are representative of 3 cultures. (I) Effects of inhibition of RAF1/ERK signalling on PI incorporation with 10 μM GW5074 or AKT signalling with 100 nM Akti1/2 on human primary pancreatic exocrine cell viability (n =3). SF denotes serum free. Repeated Measures ANOVA analyses with Bonferroni’s post-test were performed. *Represents statistical significance of p 2 in CD95-Ab vs. saline liver samples (n = 5 per group). (F) Venn diagram including the 751 genes upregulated in livers of mice injected with CD95-Ab & the H3K9Ac ChIP-seq data on eight-week-old mouse livers in ENCODE showing a high degree of overlap (Hypergeometric test; p value: 9.643501e−58). (G) Chart generated using custom annotation scripts shows that response to external stimulus including inflammatory & defense response processes, & cytokine-cytokine receptor interaction pathways were enriched among the 467 genes overlapping between the two groups according to KEGG pathways. Means ± SDs are shown; t test; *p 0.05, One‐way ANOVA). ZO‐1 level: P 0.05, One‐way ANOVA). ZO‐1 level: P 1 indicate brighter nuclear staining for NF-kappa B. (c) BV2 cells were incubated with 200 ng/mL LPS in the presence of ENERGI-F704 for 24 h. After treatments, cell lysates were used to determine the levels of NF-kappa B using Western blotting. Data are presented as the mean ± SEM of three independent experiments (one-way ANOVA; * & **, P < 0.05 & P < 0.01; specific comparison to LPS-treated control). Representative images of three independent experiments are shown. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25025067), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Sortilin forms homodimers in the extracellular & intracellular domains with intermolecular disulfide bonds in HEK293 cells.A, schematic of FLAG-sortilin Full, ECD+TMD, & ICD+TMD. SP, signal peptide; PP, propeptide. B & C, protein expression of FLAG-sortilin Full, ECD+TMD, & ICD+TMD was validated in reducing (B) & non-reducing (C) Western blotting using anti-FLAG antibody. FLAG-sortilin Full & ECD+TMD form homodimers & multimers. Empty vector was used as a control. D, HEK293 cells transiently overexpressing FLAG-sortilin Full or ECD+TMD were treated with a cross-linker, BS3, & the cell lysates were used for reducing Western blotting with anti-FLAG antibody, showing dimerization of sortilin Full & ECD+TMD (n = 3). E, HEK293 cells stably overexpressing FLAG-sortilin ICD+TMD (FLAG-sortilin ICD+TMD HEK293 cells) were incubated with DMSO (Control), 20 μmol/liter MG-132 (MG) or 10 μmol/liter chloroquine (Chlo) for 7 h, & then reducing Western blotting was performed using anti-sortilin antibody. MG-132 increased the protein expression of FLAG-sortilin ICD+TMD, but chloroquine did not (n = 3). F, FLAG-sortilin ICD+TMD HEK293 cells were incubated with DMSO or MG-132 (2–20 μmol/liter) for 7 or 24 h. MG-132 increased FLAG-sortilin ICD+TMD in a time- & concentration-dependent manner (n = 3). G, following 16-h incubation of HEK293 cells (Control) or FLAG-sortilin ICD+TMD HEK293 cells (ICD+TMD) with MG-132 (5 μmol/liter) & immunoprecipitation with anti-FLAG antibody, non-reducing Western blotting showed dimerization of sortilin ICD+TMD using anti-sortilin antibody (n = 3). Monomers, homodimers, & multimers are abbreviated as MO, D, & MU, respectively. IB, immunoblotting. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29382723), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - RAF1/ERK signalling is preferentially required for PANC1 cell survival in the absence of exogenous insulin. (A) Effects of different small molecule inhibitors on propidium iodide (PI) incorporation (PI) in PANC1 cells were tracked & expressed as the fold change in the percent of PI & Hoechst co-positive cells over total Hoechst positive cells at that hour relative to t =0 hour. Kinetic data were analyzed relative to serum-free control by two-way ANOVA (n =3) Data points that have been shaded solid black represent statistical significance when compared to non-treated conditions at that time point. # Indicates statistical significance in cells treated with Akti1/2 when compared to control at that time point. (B) Average number of PI positive cells over time of each treated group in Figure 5A is shown as a histogram expressed in arbitrary units (AU). GW5074 exhibited statistical significance, where as other treatments did not yield significance. U0126 p = 0.38, GW5074 *p = 0.0005, Akti-1/2 p = 0.395, Wort. p = 0.292 (n = 3). (C) The effect of 24 hours treatment with inhibitors on cleaved caspase 3 protein levels in PANC1 cells. This is a representative immunoblot of three independent biological replicates (n =3). (D-E) PANC1 cells were serum starved & treated with either DMSO, 10 μM GW5074, 10 μM U0126, 200 nM Akti-1/2 & 1 mM wortmannin (wort.) for 24 hours & 120 hours (n =4-5). Cell viability of PANC1 cells was expressed as the fold change of the treated relative to control. (C-E) One-way ANOVA analysis with Bonferroni post-test was performed. *Represents statistical significance of p < 0.05 where treated groups are compared to control (-) in the post-hoc test. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25373319), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Analysis of HCAR expression in D2 & D2G retina & ON. a, b Bar graphs showing Hcar1 (a), ***p = 0.0001, & Hcar2 (b) mRNA normalized to Hprt mRNA by qRT-PCR; n = 8 ON per group. c Immunohistochemical analysis of HCAR1 (red) expression in the untreated (Unt) & keto D2 retina & ON. GFAP (green) labels Müller glia & astrocytes, Iba1 (cyan) labels microglia, & DAPI (blue) stains nuclei. Arrows indicate colocalization of HCAR1 with Iba1+ microglia & GFAP+ astrocytes. d, e Percentage of mean fluorescence of HCAR1 in the inner retina (d), **p = 0.0036, & in the ROI of the proximal ON (e), ***p = 0.0001; five retinae per group, with five sections/retina. f Western blot analysis of HCAR1 protein level in retina. g Quantification by densitometry of HCAR1 protein normalized to beta -actin, ***p = 0.0008; n = 3 blots per group, each with independent samples. h HCAR1 protein in the ON normalized to beta -actin levels, as determined by capillary electrophoresis, **p = 0.0025; n = 3 ON per group. All bar graphs are presented as the mean ± SEM, n = 5, analyzed by two-tailed unpaired t test. Scale bar, 20 μm Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30424795), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Simple Western: beta-Actin Antibody (AC-15) [NB600-501] - iPSC-RPE from an ARB donor show reduced levels of Best1 expression compared to five different iPSC-RPE control lines. (A) To compare Best1 protein expression levels between different iPSC-RPE lines, beta -actin was used as a loading control. (B) While iPSCs displayed no detectable Best1 protein expression, all shown iPSC-RPE lines – regardless of donor origin – displayed detectable Best1 protein expression. (C) The three control iPSC-RPE lines derived from unrelated, unaffected donors all exhibited similar levels of Best1 protein expression. The dad exhibited reduced levels compared to the unrelated controls & the mom showed levels that were about 50% that of the dad. This was expected as the antibody used cannot detect the mutant Best1I366fsX18 which both the mom & the ARB patient are heterozygous for. Best1 expression levels in the ARB iPSC-RPE line were about a quarter of the levels observed in the Mom 214 iPSC-RPE clone. (D) Widefield immunofluorescent staining of Best1 reveals basolateral staining in each of the iPSC-RPE lines, indicating that Best1 protein is properly localized regardless if Best1R141H and/or Best1I366fsX18 are present. Immunofluorescent signal was notably weaker in the ARB iPSC-RPE clones than in the control clones. Image collected & cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-018-21651-z), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Nifedipine & the expression p-AMPK, SREBP-1/2(nuclear), PPAR-alpha (nuclear) & lipin-1 (nuclear) in 48 h. (a) The AMPK/actin was upregulated to 107.1%, 112.6%, & 116.4%, significantly at doses of 7.5, 15, & 30 μM (p < 0.05), the ratio p-AMPK/AMPK was downregulated to 82.1%, 58.7%, & 49.9%, respectively. (b,c) SREBP-1 was activated in control. The SREBP-1/HDAC was upregulated to 109.9% & 132.0% by nifedipine at doses of 7.5 & 30 μM, respectively (p < 0.01); The SREBP-2 were elevated to 127.5%, 146.7% & 161.0% by nifedipine at doses of 7.5, 15 & 30 μM, respectively (p < 0.05 in 7.5 μM, p < 0.01 in 15 & 30 μM) (d) nifedipine downregulated PPAR-alpha . The PPAR alpha /Lamin B was suppressed from 80.2%, 85.6%, to 96.4% compared to control (100%) upon administration of nifedipine at doses 7.5, 15 & 30 μM, respectively. (p < 0.05 in 15 & 30 μM) (e) Lipin-1 was activated in control. The lipin-1/lamin B was upregulated after nifedipine treatment to 102.5%, 115.8% & 121.1%, respectively, by nifedipine at doses of 7.5, 15, & 30 μM, respectively (p < 0.05 in 15 & 30 μM). p-values ≤ 0.05 (marked as *) were considered statistically significant. In addition, p-values ≤ 0.01 are marked as **. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30934807), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - JEV NS5 interacts with mitochondrial trifunctional protein (MTP), the enzyme complex involved in LCFA beta -oxidation.(A) Western blot analysis of protein levels of the indicated proteins in A549 cells with JEV infection (MOI = 10) or NS5-Flag overexpression. (B) Western blot analysis of V5-tag, Flag-tag, & actin in HEK293T cells co-transfected with HADH alpha -V5-His plus the indicated plasmids expressing Flag-tagged JEV viral proteins for 24 h, then immunoprecipitated with anti-Flag affinity gel. WCL, whole-cell lysates. (C) Immunoprecipitation (IP) analysis with control IgG or anti-Flag affinity gel in A549, GFP-A549 & NS5-Flag-A549 cells. The protein bands identified as HADH alpha & HADH beta are indicated by arrows. (D) IP with anti-Flag affinity gel & Western blot analysis with the indicated antibodies in HEK293T cells co-transfected with vector control or NS5-Flag plus HADH alpha -V5-His or HADH beta -HA for 24 h. (E) IP analysis with nickel beads & Western blot analysis with the indicated antibodies in HEK293T cells adsorbed with JEV for 3 h, then transfected with vector control, HADH alpha -V5-His or HADH beta -V5-His for 24 h. Image collected & cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.ppat.1004750), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - The effect of AM1241, SB203580, & PDTC on the thermal threshold & the expression of P2Y12 & P2Y13 receptors. Data are presented as TWL. All values represent mean ± standard deviation. a Comparison of thermal stimulation pain threshold in the ipsilateral hind paw of rats (n = 8). Spinal ADPbetaS injection reduced TWL from days 3 to 7 after ADPbetaS injection. *P < 0.05 compared w/ control group. Pretreated w/ AM1241 (100 PM, 20 min), SB203580 (50 μM), or PDTC (5 μg/10 μl) significantly inhibited the reduced w/drawal threshold days 3 to 7 in ADPbetaS-treated rats, respectively (compared w/ ADPbetaS-treated rats, AM1241: P < 0.05; SB203580: P < 0.05; PDTC: P < 0.05). b RT-PCR results show the expression of P2Y12 mRNA expression in the dorsal spinal cord of the rats in every groups (n = 8 per group). *P < 0.05 means comparison w/ the control group; +P < 0.05 means comparison w/ the ADPbetaS-treated rats. c RT-PCR results show the expression of P2Y13 mRNA expression in the dorsal spinal cord of the rats in every group (n = 8 per group). *P < 0.05 means comparison w/ the control group; +P < 0.05 means comparison w/ the ADPbetaS-treated rats. d Western blotting image of P2Y12R expression. The top panel the target band, P2Y12R, & the bottom one for the loading control beta-actin. e Western blotting quantitative analysis of the P2Y12R expression in the dorsal spinal cord of the rats. *P < 0.05 means comparison w/ the control; +P < 0.05 means comparison w/ the ADPbetaS-treated rats. f Western blotting quantitative analysis of the P2Y13R expression in the dorsal spinal cord of the rats. *P < 0.05 means comparison w/ the control; +P < 0.05 means comparison w/ the ADPbetaS-treated rats Image collected & cropped by CiteAb from the following publication (//jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0960-0), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effects of insulin on AKT & ERK phosphorylation & cell viability in primary human pancreatic duct cells. Phosphorylated AKT & ERK were measured in primary pancreatic exocrine cultures treated with the indicated concentrations of insulin for 5 minutes (A, B) & 24 hours (C, D) (n =3-4) Fold refers to the fold change of sample relative to control at the same time point. (E) Quantification of automated cell-counting studies employing live-cell imaging of Hoechst-labeled cell cultures over 60 hours. (n =3). (F) Quantification of proliferation by BrdU staining of treated relative to untreated over 3 days (n =4). (G) Quantification of the average number of dying/dead treated cells, propidium iodide (PI) labeled, over 60 hours relative to non-treated cells. (n =3). (H) Human exocrine cells were exposed to 0, 0.2, 2, 20, 200 nM insulin for 3 days. Bright-field images are representative of 3 cultures. (I) Effects of inhibition of RAF1/ERK signalling on PI incorporation with 10 μM GW5074 or AKT signalling with 100 nM Akti1/2 on human primary pancreatic exocrine cell viability (n =3). SF denotes serum free. Repeated Measures ANOVA analyses with Bonferroni’s post-test were performed. *Represents statistical significance of p < 0.05 when compared to DMSO control. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25373319), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Intrathecal injection of SB203580 (50 μM) or PDTC (5 μg/10 ml) suppressed the increased expression of P2Y12 & P2Y13R in the dorsal spinal cord of CCI rats. a Comparison of thermal stimulation pain threshold in the ipsilateral hind paw of the rats (n = 8). Data are presented as TWL. CCI reduced TWL from days 1 to 7 after nerve injury. *P < 0.05 compared with control group. Pretreated with SB203580 (50 μM) or PDTC (5 μg/10 ml) significantly inhibited the reduced withdrawal threshold days 1 to 7 in CCI rats, respectively (compared with vehicle-treated CCI group, SB203580: +P < 0.05; PDTC: +P < 0.05). b RT-PCR results show the expression of P2Y12 mRNA expression in the rat dorsal spinal cord (n = 8 per group). *P < 0.05 means comparison with the control group; +P < 0.05 means comparison with the vehicle-treated CCI group. c RT-PCR results show the expression of P2Y13 mRNA expression in the rat dorsal spinal cord (n = 8 per group). *P < 0.05 means comparison with the control group; +P < 0.05 means comparison with the vehicle-treated CCI group. d Western blotting image of P2Y12R & P2Y13R expression. The top panel was the target band, & the bottom one was for the loading control beta-actin. e Western blotting quantitative analysis of the P2Y12R expression in the rat dorsal spinal cord. *P < 0.05 means comparison with the sham group; +P < 0.05 means comparison with the vehicle-treated CCI group. f Western blotting quantitative analysis of the P2Y13R expression in the rat dorsal spinal cord. *P < 0.05 means comparison with the sham group; +P < 0.05 means comparison with the vehicle-treated CCI group Image collected & cropped by CiteAb from the following publication (//jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0960-0), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effects of HSM on the expression of P2X4R & P2X7R & ROS production in human macrophages.Cells were pretreated with various concentrations (1 or 2%) of HSM extract for 20 h, followed by treatment with LPS (0.5 μg/ml) for 3 h & ATP (5 mM) for 1 h. (a) The mRNA expression levels of P2X4R & P2X7R were determined by RT-PCR, using beta -actin as the internal control. (b) P2X4R & P2X7R mRNAs were quantified using real-time PCR. beta -actin gene expression was used for normalization. The results are expressed as fold changes, considering one as the value of untreated cells. (c) Cell lysates were analyzed by Western blot analysis used specific anti-P2X4R & anti-P2X7R antibodies. (d) ROS production was measured with the total ROS detection kit, using a fluorescence microplate reader. Pyocyanin (200 μM), a ROS inducer, was used as a positive control for ROS formation. Data are presented as means ± SE of three experiments preformed in duplicate. #P < 0.01 versus untreated cells. versus HSM-untreated control (ethanol) cells. *P < 0.01 versus HSM-untreated control (ethanol) cells. †P < 0.05 versus HSM (1%) treated cells. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/23459183), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Zinc-finger motifs of ZAP are required for JEV RNA binding & its antiviral activity.(A) Schematic representation of human ZAP isoforms (ZAP-L, 902 a.a. & ZAP-S, 699 a.a.). The four tandem CCCH-type zinc-finger (ZF) motifs within the N-terminus of ZAP are shown as solid black boxes. Deletion of the four ZFs (a.a. 73–193) are indicated with a dashed line. (B) 293T/17 cells infected with JEV (MOI = 5) for 16 h were transfected with plasmids expressing EGFP, WT or ZF-deleted ZAP-L-V5 & ZAP-S-V5 for additional 24 h. The viral RNA bound with V5-tagged proteins was pulled down by anti-V5 agarose affinity gel & amplified by RT-PCR with JEV 3′-UTR specific primers (middle panel). RT-PCR of input viral RNA in JEV-infected cells (lower panel). Western blot analysis of the immunoprecipitated ZAP-L & ZAP-S (WT & del4ZFs) (upper panel). (C-E) The indicated cells were infected with JEV (MOI = 5) for 10 h. Cell lysates, total RNA, & culture supernatants were determined for the indicated proteins by western blot (C), viral RNA by RT-PCR (D), & viral titer by plaque assay (E). Representative data from three independent experiments shown as mean ± SD (n = 3) were analyzed by two-tailed Student’s t test. *** P≤0.001. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30016363), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effects of HSM on IL-1 beta gene expression & secretion in human macrophages.Cells were pre-treated with either 1 or 2% of HSM extract for 20 h, followed by treatment with LPS (0.5 μg/ml) for 3 h & with ATP (5 mM) for 1 h. (a) The mRNA expression levels of IL-1 beta were determined by RT-PCR analysis. (b) IL-1 beta mRNAs were quantified using real-time PCR. beta -actin gene expression was used for normalization. The results are expressed as fold changes, considering one as the value of untreated cells. (c) The amount of IL-1 beta in cell culture supernatants was detected by ELISA. (d) The presence of IL-1 beta in cell lysates & cell culture supernatants were analyzed by Western blot analysis. Data are presented as means ± SE of three experiments performed in duplicate. #P < 0.01 versus untreated cells. *P < 0.01 versus HSM-untreated (ethanol-treated) control cells. †P < 0.05 versus HSM (1%) treated cells. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/23459183), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Intrathecal injection of AM1241 (100pM) attenuated CCI-induced hyperalgesia & increased expression of p-p38MAPK & NF-kappaBp65 in the rat dorsal spinal cord (n = 8 per group). a Western blotting image of p-p38MAPK expression. The top panel was the target band, p-p38MAPK, & the bottom one was for the loading control beta-actin. b Western blotting quantitative analysis of the p-p38MAPK expression in the rat dorsal spinal cord. *P < 0.05 means comparison with the sham group; +P < 0.05 means comparison with the vehicle-treated CCI group. c Western blotting image of NF-kappaBp65 expression. The top panel was the target band, NF-kappaBp65, & the bottom one was for the loading control beta-actin. d Western blotting quantitative analysis of the NF-kappaBp65 expression in the dorsal spinal cord of the rats. *P < 0.05 means comparison with the sham group; +P < 0.05 means comparison with the vehicle-treated CCI group Image collected & cropped by CiteAb from the following publication (//jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0960-0), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Intralipid enhances the cytotoxicity of Abraxane in tumors. (A) The box-and-whisker plot represents the amount of paclitaxel in tumors determined by LC/MS. The number above the box denotes the median amount of remaining paclitaxel in the tumor tissues. (B) Western blot analysis of the apoptosis signal, cleaved caspase-3, in the tumors at 24 & 48 hrs after Abraxane treatment. beta -actin served as a loading control. The blots of caspase-3 & beta -actin are cropped from different parts of the same gel. The intensity of each band of the cleaved caspase-3 was measured by ImageJ software (NIH) & normalized to its own signal of beta -actin. The values summarized in the box-and-whisker plot denote the relative intensities compared with those in the control group. (C,D) The immunohistochemistry of cleaved caspase-3 (C) & the TUNEL assay (D) are analyzed in 48 hrs tumor sections. Original: 200x magnification; Inserts; 400x magnification. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32071352), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - The effect of minocycline on the expression of P2Y12 & P2Y13 receptors. All values represent mean ± standard deviation. a RT-PCR results show the expression of P2Y12 mRNA expression in the rat dorsal spinal cord (n = 8 per group). *P < 0.05 means comparison with the sham group; +P < 0.05 means comparison with the CCI rats. b RT-PCR results show the expression of P2Y13 mRNA expression in the rat dorsal spinal cord (n = 8 per group). *P < 0.05 means comparison with the sham group; +P < 0.05 means comparison with the CCI rats. c Western blotting quantitative analysis of the P2Y12R expression in the rat dorsal spinal cord. *P < 0.05 means comparison with the control; +P < 0.05 means comparison with the ADPbetaS-treated rats. d Western blotting quantitative analysis of the P2Y13R expression in the rat dorsal spinal cord. *P < 0.05 means comparison with the control; +P < 0.05 means comparison with the ADPbetaS-treated rats. e Western blotting image of P2Y12R expression. The top panel was the target band, P2Y12R, & the bottom one was for the loading control beta-actin. f Western blotting image of P2Y13R expression. The top panel was the target band, P2Y13R, & the bottom one was for the loading control beta-actin Image collected & cropped by CiteAb from the following publication (//jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0960-0), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effects of HSM on inflammasome components & caspase-4 activation in human macrophages.Cells were pretreated with various concentrations (1 or 2%) of HSM extract for 20 h, followed by treatment with LPS (0.5 μg/ml) for 3 h & ATP (5 mM) for 1 h. (a) The mRNA expression levels of ASC, NLRP1, NLRP3 & caspase-4 were determined by RT-PCR, using beta -actin as the internal control. (b) ASC, NLRP1, NLRP3 & caspase-4 mRNAs were quantified using real-time PCR. beta -actin gene expression was used for normalization. The results are expressed as fold changes, considering one as the value of untreated cells. (c) Cell lysates were analyzed by Western blot analysis using specific anti-ASC, anti-NLRP1 & anti-NLRP3 antibodies. (d) Cell lysates were analyzed for protein levels of caspase-4 by Western blot analysis. beta -actin was used as an internal control. Data are presented as means ± SE of three experiments preformed in duplicate. #P < 0.01 versus untreated cells. versus HSM-untreated control (ethanol) cells. *P < 0.01 versus HSM-untreated control (ethanol) cells. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/23459183), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - The cleaved MFN fragments were further degraded by host proteasome machinery.(A) Western blot analysis of A549+on/MFN1 (lane 1–6) & /MFN2 (lane 7–12) cells with Dox treatment (all lanes) & DENV infection (lane 3–6 & 9–12). The cells were infected with DENV serotype 2 (moi 5) for 24 h, then incubated in culture media containing Dox (1 μg/ml) with (lanes 5–6 & 11–12) or without MG132 (0.5 μM) for 16 h. (B) Western blot analysis of four different serotypes DENV-infected A549 cells incubated with MG132-containing medium. (C) Western blot analysis of endogenous MFN1 & 2 cleavage in A549 stable cells overexpressing WT or protease-dead mutant (S135A) of DENV NS2B3 with or without 18-h treatment with MG132 (0.5 μM). Filled arrow: full-length; open arrow: cleaved product; star: non-specific band. The longer exposure images for endogenous MFN1 & 2 signals are also shown in panels B & C. Image collected & cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.ppat.1005350), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - ENERGI-F704 decreases LPS-induced NO, iNOS, COX-2, & PGE2 production in BV2 cells. BV2 cells were stimulated with 200 ng/mL LPS & subsequently treated with either ENERGI-F704 or AICAR for 24 h. (a) Levels of NO in the culture of BV2 cell were determined. (b) After treatments, cell lysates were used to determine the level of iNOS & COX-2 using Western blotting. (c) LPS-treated BV2 cells were treated with ENERGI-F704 in cotreatment with or without compound C for 24 h. Cell lysates were used to determine the level of iNOS & COX-2 using Western blotting. (d) LPS-induced BV2 cells were treated with ENERGI-F704 in cotreatment with or without compound C for 48 h, & the level of PGE2 in the culture medium was determined. Data are presented as the mean ± SEM of three independent experiments (two-way ANOVA; *, **, & ***, P < 0.05, P < 0.01, & P < 0.01; specific comparison to LPS-treated control). Representative images of three independent experiments are shown. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25025067), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Simple Western: beta-Actin Antibody (AC-15) [NB600-501] - iPSC-RPE from all donors express RPE marker proteins. (A) As a loading control, each iPSC-RPE line (ARB patient, the patient’s parents, & three unrelated, unaffected controls) as well as iPSCs (negative control) were blotted for beta -actin. (B) Unlike iPSCs, all iPSC-RPE lines showed robust expression of CRALBP. (C) Just like CRALBP, iPSC-RPE from the patient, the patient’s mom, the patient’s dad, & the three unrelated, unaffected controls all expressed RPE65. The negative control (iPSCs) had no detectable RPE65 protein expression. (D) Each of the iPSC-RPE lines but not iPSCs displayed strong expression of the RPE marker Mer-tk. (E) The relative expression levels for each of these three markers is summarized for iPSCs & all of the iPSC-RPE lines. Graphs show the summary of expression for each marker from three separate blotting experiments. Variability between each of the controls as well as between the different iPSC-RPE lines was observed for each of the RPE markers. Control 4 displayed the highest levels of CRALBP, Control 138 had the highest levels of RPE65, & Control 1 showed the highest levels of Mer-tk. Image collected & cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-018-21651-z), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: beta-Actin Antibody (AC-15) [NB600-501] - Effects of MFN1 or MFN2 overexpression on DENV infection.(A) Western blot analysis of A549+on/HA-MFN1 cells induced with Dox (1 μg/ml) or not for 18 h, then infected with DENV serotype 2 for 24 or 48 h by the indicated moi. The relative ratios of band intensity were quantified by ImageJ. p.i. (h): hours post infection. (B) DENV plaque-forming assay of culture supernatants from A549+on/HA-MFN1 cells cultured with or without Dox (1 μg/ml) for 18 h, then infected with DENV (moi 0.1 or 10) as indicated. Data in panels B-D & F-G are mean ± SD (n = 3 per group) & were compared by two-tailed Student’s t test. (C) RT-qPCR analysis of IFN beta mRNA expression at indicated time point in DENV-infected (moi 10) A549+on/HA-MFN1 cells with or without an 18 h-Dox-pretreatment. (D) Analysis of antiviral activity against dSinF-Luc/2A virus in culture media from A549+on/HA-MFN1 cells with DENV infection (moi 5, 48 h) with or without 18-h Dox pretreatment. (E) Western blot analysis of A549+on/HA-MFN2 cells induced with Dox (1 μg/ml, 18 h) or not, then infected with DENV (moi 10) for the indicated time. (F & G) Analysis of the culture supernatants derived from panel E for DENV titer (F) & LDH release (G). (H) Flow cytometry of A549+on/HA-MFN2 cells double stained with JC-1 & annexin V. Cells were infected with DENV (moi 5) for 48 h with or without 18-h Dox pre-treatment. Decreased red/green fluorescence ratio of JC-1 represents disrupted MMP. Image collected & cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.ppat.1005350), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

• Reactivity: Hu, Mu, Rt, Po, Bv, Ca, Ch, Fe, Fi, Gp, Ha, Le, Ma, Pm, Rb, Sh, Sq, Tr, Ze, Dr(-)
• Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IP, ChIP, KD, KO
• Clone: AC-15
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

beta-Actin Antibody (AC-15) Summary

• Immunogen: This beta-Actin Antibody (AC-15) was made to a slightly modified Beta-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH.
• Epitope: N-terminus of the beta isoform of actin.
• Specificity: In staining of chicken gizzard ultrathin tissue cryosections, the antibody labels the dense bodies and longitudinal channels linking consecutive dense bodies that are also occupied by desmin and the membrane-associated dense plaque. It does not stain adult cardiac and skeletal muscles except for traces due to contaminations of the sample with non-muscle cells, or if embryonic tissue is being used. The epitope recognized by the antibody is resistant to formalin-fixing and paraffin-embedding.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACTB
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP)
  • ELISA 1:100 - 1:2000
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence 1:1000 - 1:2000
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:500
  • Immunohistochemistry-Paraffin 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Knockdown Validated
  • Knockout Validated
  • Simple Western 1:25
  • Western Blot 1:5000 - 1:10000
• Application Notes: See Simple Western Antibody Database for Simple Western validation: tested in HeLa lysate (0.1 mg/ml); antibody dilution of 1:25; separated by size; detects a band at 54 kDa..
• Theoretical MW: 42 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

The antibody cross reacts with beta-actin expressing cells in carp, leech tissues (Hirudo medicinalis), ground squirrel. Does not cross react with adult cardiac, skeletal muscle, drosophila or amoeba beta actin. Mammal reactivity and Hamster reactivity reported in scientific literature (PMID: 25130694 and 24478435 respectively). Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information. Human reactivity reported in scientific literature (PMID:32938681) Use in Turkey reported in scientific literature (PMID:27816932).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites.
• Preservative: 0.09% Sodium Azide
• Purity: Unpurified

Alternate Names for beta-Actin Antibody (AC-15)

• ACTB
• actin, beta
• actin, cytoplasmic 1
• anti-beta actin
• B-Actin
• beta actin (ac-15)
• Beta Actin
• beta cytoskeletal actin
• beta-actin ac 15
• beta-actin ac15
• beta-actin ac-15
• betaActin
• beta-Actin
• BRWS1
• I(2)-Actin
• PS1TP5-binding protein 1
• PS1TP5BP1

Background

Actin is a highly conserved protein involved in cell motility, structure, and integrity. Six functional actin isoforms exist and were named based on their electrophoretic mobility and distribution including alpha-cardiac muscle actin (aCAA), alpha-skeletal muscle actin (aSKA), alpha-smooth muscle actin (aSMA), beta-cytoplasmic actin (bCYA), gamma-cytoplasmic actin (gCYA) and gamma-smooth muscle actin (gSMA) (1). The cytoplasmic isoforms, beta-actin and gamma-actin, are nearly identical, differing by only 4 amino acids at the N-terminus with a theoretical molecular weight of 42 kDa (2). Beta-actin is ubiquitously expressed in eukaryotic cells and considered a housekeeping gene which is frequently used as a loading control for assays involving protein detection, such as Western blotting (3,4).

References

1. Vandekerckhove J, Weber K. 1978. At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol. 126(4):783-802. PMID: 745245

2. Gimona M, Vandekerckhove J, Goethals M, Herzog M, Lando Z, Small JV. (1994) Beta-actin specific monoclonal antibody. Cell Motil Cytoskeleton. 27(2):108-16. PMID: 8162619

3. Holden VI, Lenio S, Kuick R, Ramakrishnan SK, Shah YM, Bachman MA. (2014) Bacterial siderophores that evade or overwhelm Lipocalin 2 induce HIF-1a and pro-inflammatory cytokine secretion in cultured respiratory epithelial cells Infect Immun. 82(9):3826-36 PMID: 24980968

4. Tsai WL, Yeh PH, Tsai CY, Ting CT, Chiu YH, Tao MH, Li WC, Hung SC. (2016) Efficient Programming of Human Mesenchymal Stem Cell Derived Hepatocytes by Epigenetic Regulations. J. Gastroenterol. Hepatol. 32(1):261-269. PMID: 27218433

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for beta-Actin Antibody (NB600-501)(577)

Publications using NB600-501

• Santos J, La Fuente JM, Fernández A et Al. LDL-c/HDL-c Ratio and NADPH-Oxidase-2-Derived Oxidative Stress as Main Determinants of Microvascular Endothelial Function in Morbidly Obese Subjects Antioxidants (Basel) 2024-09-20 [PMID: 39334798]
• Lin YS, Tsai YC, Li CJ et al. Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer Redox Biology 2024-09-18 [PMID: 39317106]
• Su CI, Chuang ZS, Shie CT et Al. A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning Nat Commun 2024-08-04 [PMID: 39098891]
• Luke A Bourner, Linda A Chung, Haiyan Long, Anne F McGettrick, Junpeng Xiao, Kenneth Roth, Jade D Bailey, Marie Strickland, Bo Tan, Jason Cunningham, Barry Lutzke, James McGee, Francella J Otero, David C Gemperline, Lin Zhang, Ying C Wang, Michael J Chalmers, Chiao-Wen Yang, Jesus A Gutierrez, Luke A J O'Neill, Frank C Dorsey Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages. Cell reports 2024-08-01 [PMID: 39093697]
• Jonathan Gagnon, Véronique Caron, André Tremblay SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells Cell & Bioscience 2024-07-13 [PMID: 38997783]
• Haressh Sajiir, Sahar Keshvari, Kuan Yau Wong, Danielle J. Borg, Frederik J. Steyn, Christian Fercher, Karin Taylor, Breten Taylor, Ross T. Barnard, Alexandra Müller, Md Moniruzzaman, Gregory Miller, Ran Wang, Amelia Fotheringham, Veronika Schreiber, Yong Hua Sheng, Janelle Louise Hancock, Dorothy Loo, Lucy Burr, Tony Huynh, Jack Lockett, Grant A. Ramm, Graeme A. Macdonald, Johannes B. Prins, Michael A. McGuckin, Sumaira Z. Hasnain Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis Nature Communications 2024-05-29 [PMID: 38811532]
• Chao, YM;Wu, HY;Yeh, SH;Yang, DI;Her, LS;Wu, YL; Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production International journal of molecular sciences 2024-04-10 [PMID: 38673797]
• Yoann Vial, Jeannette Nardelli, Adeline A Bonnard, Justine Rousselot, Michèle Souyri, Pierre Gressens, Hélène Cavé, Séverine Drunat Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis. EMBO reports 2024-04-11 [PMID: 38605277]
• Charlotte Herbst, Viktoria Bothe, Meret Wegler, Susanne Axer-Schaefer, Séverine Audebert-Bellanger, Jozef Gecz, Benjamin Cogne, Hagit Baris Feldman, Anselm H. C. Horn, Anna C. E. Hurst, Melissa A. Kelly, Michael C. Kruer, Alina Kurolap, Annie Laquerriere, Megan Li, Paul R. Mark, Markus Morawski, Mathilde Nizon, Tomi Pastinen, Tilman Polster, Pascale Saugier-Veber, Jang SeSong, Heinrich Sticht, Jens T. Stieler, Isabelle Thifffault, Clare L. van Eyk, Pascale Marcorelles, Myriam Vezain-Mouchard, Rami Abou Jamra, Henry Oppermann Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly Human Genetics 2024-03-25 [PMID: 38526744]
• Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity Cell Death & Disease 2024-02-09 [PMID: 38336804]
• EswarKumar N, Yang CH, Tewary S, Peng WH et Al. An integrative approach unveils a distal encounter site for rPTP? and phospho-Src complex formation Structure 2023-10-05 [PMID: 37794594]
• Huo Y, Cheng C, Wang S et al. A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects Peptides 2023-09-30 [PMID: 37778465] (WB, Mouse)
• Nishikawa Y, Matsuo Y, Watanabe R et al. Hepatocyte-specific damage in acute toxicity of sodium ferrous citrate: Presentation of a human autopsy case and experimental results in mice Toxicology reports 2023-05-30 [PMID: 37304377] (WB, Mouse)
• Sidor K, Jeznach A, Hoser G, Skirecki T 1-Methylnicotinamide (1-MNA) inhibits the activation of the NLRP3 inflammasome in human macrophages International immunopharmacology 2023-06-06 [PMID: 37290319] (Western Blot, Human)
• Hajime Asada, Akiyoshi Tani, Hiroki Sakuma, Miyuki Hirabayashi, Yuki Matsumoto, Kei Watanabe, Masaya Tsuboi, Shino Yoshida, Kei Harada, Takao Uchikai, Yuko Goto-Koshino, James K. Chambers, Genki Ishihara, Tetsuya Kobayashi, Mitsuhiro Irie, Kazuyuki Uchida, Koichi Ohno, Makoto Bonkobara, Hajime Tsujimoto, Hirotaka Tomiyasu Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma Scientific Reports 2023-05-25 [PMID: 37231193]
• Rong Z, Yang L, Chen Y et al. Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund's adjuvant Molecular pain 2023-05-19 [PMID: 37207346] (WB, Mouse)
• Douglas C, Lomeli N, Vu T et al. LonP1 Drives Proneural Mesenchymal Transition in IDH1-R132H Diffuse Glioma SSRN Electronic Journal 2023-03-15 [PMID: 37131765] (Western Blot, Human)
• Zhao M, Stefanick D, Nadalutti C et al. Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols DNA Repair 2023-03-01 [PMID: 37028218]
• Chiu KW, Chen HY, Chen CL et al. Attenuation of Endoplasmic Reticulum Stress Enhances Carvacrol-Induced Apoptosis in Osteosarcoma Cell Lines Life (Basel, Switzerland) 2023-03-09 [PMID: 36983900] (WB, Human)
• Ngo J, Choi DW, Stanley IA et al. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA The EMBO journal 2023-03-14 [PMID: 36917141]
• Alex Frias, Luca Di Leo, Asier Antoranz, Loulieta Nazerai, Marco Carretta, Valérie Bodemeyer, Chiara Pagliuca, Christina Dahl, Giuseppina Claps, Giulio Eugenio Mandelli, Madhavi Dipak Andhari, Maria Pires Pacheco, Thomas Sauter, Caroline Robert, Per Guldberg, Daniel Hargbøl Madsen, Francesco Cecconi, Francesca Maria Bosisio, Daniela De Zio Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma Journal for Immunotherapy of Cancer 2023-01-01 [PMID: 36868570]
• Cheng YS, Chen HY, Lin YC et al. The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia Andrology 2023-02-13 [PMID: 36779514]
• Davis C, Ammi A, Zhu W et al. Low-Intensity Ultrasound Reduces Brain Infarct Size by Upregulating Phosphorylated Endothelial Nitric Oxide in Mouse Model of Middle Cerebral Artery Occlusion Ultrasound in Medicine & Biology 2023-02-01 [PMID: 36739244] (WB, Mouse)
  
  Details:
  Dilution used in WB 1:8,000
• Dougherty J, Harvey K, Liou A et al. Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas PloS one 2023-02-02 [PMID: 36730269]
• Wang C, Chan D, Hendrickson E Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair DNA Repair 2022-12-01 [PMID: 36608404]
• Kuo FC, Wang YT, Liu CH et al. LncRNA HOTAIR impairs the prognosis of papillary thyroid cancer via regulating cellular malignancy and epigenetically suppressing DLX1 Cancer cell international 2022-12-09 [PMID: 36494673] (WB, Human)
  
  Details:
  Dilution used in WB 1:10,000
• Laoukili J, van Schelven S, Kucukkose E et al. BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis Cell reports 2022-11-29 [PMID: 36450250] (WB, Human)
• El Assar M, GarcIa-Rojo E, Sevilleja-Ortiz A Et al. Functional Role of STIM-1 and Orai1 in Human Microvascular Aging Cells 2022-11-26 [PMID: 36429103] (WB, IF/IHC, Human)
  
  Details:
  Citation using the HRP version of this antibody.
• Pakalniskyte D, SchOnberger T, Strobel B et al. Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery Scientific reports 2022-11-10 [PMID: 36357523] (Simple Western, Mouse)
  
  Details:
  Dilution used in Simple Western 1:20
• Vassal M, Pereira CD, Martins F et al. Different Strategies to Attenuate the Toxic Effects of Zinc Oxide Nanoparticles on Spermatogonia Cells Nanomaterials (Basel, Switzerland) 2022-10-11 [PMID: 36296751] (WB, Mouse)
• Song L, Yao X, Li H et al. Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer Molecular cell 2022-10-18 [PMID: 36272410] (WB, Human)
• Tsai YT, Huang HC, Kao ST et al. Neuroprotective Effects of Alpinia oxyphylla Miq against Mitochondria-Related Apoptosis by the Interactions between Upregulated p38 MAPK Signaling and Downregulated JNK Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion in Rats The American journal of Chinese medicine 2022-10-20 [PMID: 36266752] (WB)
• Wang Y, Liao J, Chen K Et Al. Lumbrokinase regulates endoplasmic reticulum stress through IRE1 signaling to improve neurological deficits in ischemic stroke Research Square 2021-07-08 [PMID: 36223864]
• Lee T, Kim KS, Na K Intracellular pH-Regulating Nanoparticles to Improve Anticancer Drug Efficacy for Cancer Treatment Biomacromolecules 2022-10-12 [PMID: 36223489] (WB)
• Wu CK, Wei MT, Wu HC et al. BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation Scientific reports 2022-09-29 [PMID: 36175474]
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• Zhu K, Sun S, Guo F, Gao L Impaired Fanconi anemia pathway causes DNA hypomethylation in human angiosarcomas Human cell 2022-07-11 [PMID: 35817884] (WB)
• Martin CE, Murray AS, Mackinder JR et al. TMPRSS13 zymogen activation, surface localization, and shedding is regulated by proteolytic cleavage within the non-catalytic stem region Biological chemistry 2022-07-08 [PMID: 35796294]
• Tapio J, Halmetoja R, Dimova E et al. Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism Journal of Biological Chemistry 2022-07-01 [PMID: 35787374] (WB, Mouse)
• Luchtel RA, Zhao Y, Aggarwal RK et al. ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent Blood advances 2022-06-08 [PMID: 35675522] (WB, Human)
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• Yang S, Chen Z, Fan D et al. MiR-182-5p and miR-96-5p increased hepatocellular carcinoma cell mobility, proliferation and cisplatin resistance partially by targeting RND3 Am. J. Physiol. Renal Physiol. 2018-10-10 [PMID: 35547072] (WB, Human)
• Hamel KM The Age-Dependent Characterization of the ER-Alpha Positive Breast Cancer Tumor Microenvironment Thesis 2021-01-01
• Boyd Kenkhuis, Michelle van Eekeren, David A. Parfitt, Yavuz Ariyurek, Poulomi Banerjee, Josef Priller, Louise van der Weerd, Willeke M.C. van Roon-Mom Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia Stem Cell Reports 2022-05-05 [PMID: 35523178]
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• Herre C, Nshdejan A, Klopfleisch R et al. Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro PloS one 2022-04-28 [PMID: 35482724] (WB, Human)
• Chen IC, Liu YC, Wu YH et al. Proteasome Inhibitors Decrease the Viability of Pulmonary Arterial Smooth Muscle Cells by Restoring Mitofusin-2 Expression under Hypoxic Conditions Biomedicines 2022-04-09 [PMID: 35453623] (WB, Human)
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• Bhoopathi, P;Pradhan, AK;Kumar, A;Maji, S;Mannangatti, P;Deng, X;Bandyopadhyay, D;Sarkar, D;Wang, XY;Landry, JW;Das, SK;Emdad, L;Fisher, PB; Conversion of a Non-Cancer-Selective Promoter into a Cancer-Selective Promoter Cancers [PMID: 35326649] (Human)
• Shigeta S, Watanabe Y, Suzuki F et al. MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression The Tohoku journal of experimental medicine 2022-03-01 [PMID: 35314531] (WB, Human)
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• Karim S, Burzangi AS, Ahmad A Et al. PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer Int J Mol Sci 2022-02-26 [PMID: 35216429] (WB, Human)
  
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• YT Wang, TY Liu, CH Shen, SY Lin, CC Hung, LC Hsu, GC Chen K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy Cell Reports, 2022-02-22;38(8):110354. 2022-02-22 [PMID: 35196483] (Western Blot)
• Laoukili J, Constantinides A, Wassenaar ECE et al. Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity British journal of cancer 2022-02-22 [PMID: 35194192] (WB, Human)
• Byts N, Sharma S, Malm T et al. Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation The Journal of biological chemistry 2022-02-10 [PMID: 35151685] (WB, Mouse)
• Skovso S, Panzhinskiy E, Kolic J et al. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance Nature communications 2022-02-08 [PMID: 35136059] (WB, Mouse)
• Rudalska R, Harbig J, Snaebjornsson M et al. LXR alpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer Nat Cancer 2022-02-05 [PMID: 35122079]
• Rudalska R, Harbig J, Snaebjornsson M et al. LXR alpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer Nature Cancer 2021-02-01 [PMID: 35122079]
• Lamprou I, Kakouratos C, Tsolou A, Pavlidis P et Al. Lipophagy-Related Protein Perilipin-3 and Resistance of Prostate Cancer to Radiation Therapy Int J Radiat Oncol Biol Phys 2022-02-05 [PMID: 35121129]
• Chen K, Chen C, Chen C et al. Bicalutamide Exhibits Potential to Damage Kidney via Destroying Complex I and Affecting Mitochondrial Dynamics Journal of Clinical Medicine 2021-12-27 [PMID: 35011880] (WB, Rat)
• Lin CH, Liao CC, Wang SY et al. Comparative O-GlcNAc Proteomic Analysis Reveals a Role of O-GlcNAcylated SAM68 in Lung Cancer Aggressiveness Cancers 2022-01-04 [PMID: 35008409] (WB)
• So Young Kim , Supyong Hwang , Lee B et al. Inhibition of histone demethylase KDM4 by ML324 induces apoptosis through the unfolded protein response and Bim upregulation in hepatocellular carcinoma cells Chemico-Biological Interactions 2022-01-01 [PMID: 34999051] (WB, Human)
• Li R, Zhang Y, Garg A et al. E3 ubiquitin ligase FBXW7 balances airway cell fates Developmental Biology 2022-03-01 [PMID: 34998785] (WB, Mouse)
• Chen Y, Le P, Tzeng T Et al. Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems Nutrients 2021-11-29 [PMID: 34959868] (WB, Human)
• Chung NH, Chen YC, Yang SJ et al. Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein Vaccine 2021-12-17 [PMID: 34952759] (WB, Mouse)
• Pagano A, Breuzard G, Parat F Et al. Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT Axis Cancers 2021-11-19 [PMID: 34830972] (IHC-Fr, WB, Human)
• McCorkell KA, Jayachandran N, Cully MD Et al. Lymph node formation and B cell homeostasis require IKK-alpha in distinct endothelial cell-derived compartments Proceedings of the National Academy of Sciences of the United States of America 2021-11-30 [PMID: 34810256]
• Wang K, Chen PN, Chien HW Et al. Demethoxycurcumin inhibits the cell migration and MMP-2 expression in human retinal pigment epithelial cells by targeting the STAT-3 pathway Experimental eye research 2021-11-15 [PMID: 34793827] (WB, Human)
• Tornabene P, Trapani I, Centrulo M Et al. Inclusion of a degron reduces levelsof undesired inteins after AAV-mediated proteintrans-splicing in the retina Molecular Therapy - Methods & Clinical Development 2021-12-01 [PMID: 34786437] (WB, Mouse, Porcine)
• Liao GR, Tseng YY, Tseng CY Et al. The orf virus (ORFV) protein OV20.0 interacts with the microprocessor complex subunit DGCR8 to regulate miRNA biogenesis and ORFV infection FEBS letters 2021-11-14 [PMID: 34778960]
• Wang Y, Sun L, Wang L Et al. PUM1 modulates trophoblast cell proliferation and migration through LRP6 Biochemistry and cell biology = Biochimie et biologie cellulaire 2021-12-01 [PMID: 34734756]
• Mehanna ET, Khalaf SS, Mesbah NM Et al. Anti-oxidant, anti-apoptotic, and mitochondrial regulatory effects of selenium nanoparticles against vancomycin induced nephrotoxicity in experimental rats Life sciences 2021-10-26 [PMID: 34715137] (WB, Rat)
• Sevilleja-Ortiz A, El Assar M, GarcIa-Rojo E Et al. Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue Mech Ageing Dev 2021-10-26 [PMID: 34699858] (WB, Rat, Human)
  
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• Chiu H, Chiu HP, Yu HP Et al. Zinc finger protein ZFP36L1 inhibits flavivirus infection by both 5'-3' XRN1 and 3'-5' RNA-exosome RNA decay pathways Journal of virology 2021-10-13 [PMID: 34643435]
• Alam S, Mohammad T, Padder RA Et al. Thymoquinone and quercetin induce enhanced apoptosis in non-small cell lung cancer in combination through the Bax/Bcl2 cascade Journal of cellular biochemistry 2021-10-12 [PMID: 34636440]
• Iwata H, Osborn EA, Ughi GJ et Al. Highly Selective PPAR? (Peroxisome Proliferator-Activated Receptor ?) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging J Am Heart Assoc 2021-10-11 [PMID: 34632804] (Western Blot)
• Yoon H, Triplet EM, Simon WL Et al. Blocking Kallikrein 6 promotes developmental myelination Glia 2021-10-09 [PMID: 34626143]
• Chiang MK, Hsiao PY, Liu YY Et al. Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model Gut microbes 2021-10-04 [PMID: 34606408] (WB, Mouse)
• Kuraoka S, Higashi H, Yanagihara Y et al. A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN- gamma Molecular & cellular proteomics : MCP 2021-09-27 [PMID: 34592425] (WB)
• Carlet M, Voelse K, Vergalli J et al. In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets Nat Commun 2021-09-28 [PMID: 34580292]
• Martin CE, Murray AS, Sala-Hamrick KE et al. Post-translational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization The Journal of biological chemistry 2021-09-22 [PMID: 34562451] (WB, Human)
• Wang HI, Chuang ZS, Kao YT Et al. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants International journal of molecular sciences 2021-08-23 [PMID: 34445789]
• Cheng CY, Chiang SY, Kao ST, Huang SC Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats Chinese medicine 2021-08-21 [PMID: 34419138] (WB, Rat)
• Lamprou I, Tsolou A, Kakouratos C Et al. Suppressed PLIN3 frequently occurs in prostate cancer, promoting docetaxel resistance via intensified autophagy, an event reversed by chloroquine Medical oncology (Northwood, London, England) 2021-08-19 [PMID: 34410522] (WB, Human)
• Gagnon J, Caron V, Gyenizse L, Tremblay A Atypic SUMOylation of Nor1/NR4A3 regulates neural cell viability and redox sensitivity FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021-09-01 [PMID: 34383980]
• Beckermann Tm, Luo W, Wilson Cm Et Al. Cognate restriction of transposition by piggyBac-like proteins Nucleic acids research 2021-07-07 [PMID: 34232995] (WB)
• Hsieh MC, Lo YS, Chuang YC et al. Dehydrocrenatidine extracted from Picrasma quassioides induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways Oncology reports 2021-08-01 [PMID: 34165177] (WB, Human)
• Oyama Y, Shigeta S, Tokunaga H et al. CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents PloS one 2021-06-23 [PMID: 34161330] (WB, Human)
• Liu WH, VOlse K, Senft D, Jeremias I A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models Scientific reports 2021-06-16 [PMID: 34135367] (FLOW, Human)
• Lee Y, Huang H, Kao S, Cheng C Angelica Sinensis Extract Protects Against Memory Deficits by Promoting P38 MAPK mediated Hippocampal Neurogenesis and Neuronal Survival in the Chronic Phase of Transient Global Cerebral Ischemia in Rats Research Square 2020-09-17 [PMID: 34090910] (Rat)
• Cheng CY, Huang HC, Kao ST, Lee YC Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats Journal of ethnopharmacology 2021-06-04 [PMID: 34090910]
• Chuang Y, Hsieh M, Lin C et al. Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial mesenchymal transition and inhibition of MMP 2 Oncology Reports 2021-05-27 [PMID: 34080661] (WB, Human)
• Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi Loss of Ambra1 promotes melanoma growth and invasion Nature Communications 2021-05-05 [PMID: 33953176]
• Hosseini-Farahabadi S, Baradaran-Heravi A, Zimmerman C et al. Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough PLoS biology 2021-05-01 [PMID: 33939688] (WB, Human)
• Liao GR, Tseng YY, Tseng CY et al. K160 in the RNA-binding domain of the orf virus virulence factor OV20.0 is critical for its functions in counteracting host antiviral defense FEBS letters 2021-04-28 [PMID: 33909294]
• Saydam O, Saydam N., et Al. Deficiency of Ku Induces Host Cell Exploitation in Human Cancer Cells Front Cell Dev Biol 2021-03-29 [PMID: 33855027] (Western Blot)
• Chang CW, Chiu CH, Lin MH et al. GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression EJNMMI research 2021-03-16 [PMID: 33725191] (WB, Mouse)
• Wu YH, Yang Y, Chen CH et al. Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2 PLoS pathogens 2021-03-01 [PMID: 33720996] (WB, Human)
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• Chan MC, Savela J, Ollikainen RK et al. Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation Oxidative medicine and cellular longevity 2021-02-01 [PMID: 33603952]
• Triplet EM, Kim HN, Yoon H et al. The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury Neurobiology of disease 2021-02-05 [PMID: 33549720] (WB, Mouse)
• Morton RE, Mihna D, Liu Y The lipid substrate preference of CETP controls the biochemical properties of HDL in fat/cholesterol-fed hamsters Journal of lipid research 2021-01-27 [PMID: 33515552] (WB)
• Nobuhiko Kayagaki, Opher S Kornfeld, Bettina L Lee, Irma B Stowe, Karen O'Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu, Juan Zhang, Wyne P Lee, Brent S McKenzie, Gözde Ulas, Jian Payandeh, Merone Roose-Girma, Zora Modrusan, Rohit Reja, Meredith Sagolla, Joshua D Webster, Vicky Cho, T Daniel Andrews, Lucy X Morris, Lisa A Miosge, Christopher C Goodnow, Edward M Bertram, Vishva M Dixit NINJ1 mediates plasma membrane rupture during lytic cell death. Nature 2021-07-22 [PMID: 33472215]
• Cai C, Tahiri H, Fortin C, et al. Lymphocytic microparticles suppress retinal angiogenesis via targeting Müller cells in the ischemic retinopathy mouse model Experimental cell research 2021-02-15 [PMID: 33434529] (WB, Rat)
• Tsochantaridis I, Roupas A, Voulgaridou GP, et al. Aldehyde Dehydrogenase 1B1 Is Associated with Altered Cell Morphology, Proliferation, Migration and Chemosensitivity in Human Colorectal Adenocarcinoma Cells Biomedicines 2021-01-06 [PMID: 33419031] (WB, Human)
• Gul HF, Ilhan N, Ilhan N et al. The Combined Effect of Pomegranate Extract and Tangeretin on the DMBA-induced Breast Cancer Model The Journal of nutritional biochemistry 2020-12-13 [PMID: 33326843] (WB, Rat)
• Galli A, Marciani P, Marku A et al. Verbascoside Protects Pancreatic beta -Cells against ER-Stress Biomedicines 2020-12-08 [PMID: 33302345] (WB, Mouse)
• Byts N, Sharma S, Laurila J et al. Transmembrane Prolyl 4-Hydroxylase Is a Novel Regulator of Calcium Signaling in Astrocytes eNeuro 2020-12-08 [PMID: 33298456]
• Lee YC, Kao ST, Cheng CY Acorus tatarinowii Schott extract reduces cerebral edema caused by ischemia-reperfusion injury in rats: involvement in regulation of astrocytic NKCC1/AQP4 and JNK/iNOS-mediated signaling BMC complementary medicine and therapies 2020-12-09 [PMID: 33298024] (Rat)
• Chao CT, Yeh HY, Tsai YT et al. Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach Int J Mol Sci 2020-11-12 [PMID: 33198315] (WB, Rat)
• HY Chou, YT Lee, YJ Lin, JK Wen, WH Peng, PL Hsieh, SY Lin, CC Hung, GC Chen PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation Autophagy, 2020-10-28;0(0):1-16. 2020-10-28 [PMID: 33112705]
• Fenzl A, Kulterer OC, Spirk K et al. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis Mol Metab 2020-09-26 [PMID: 32992038] (WB, Mouse)
• Liu WH, Mrozek-Gorska P, Wirth AK et al. Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL Biomarker research 2020-09-16 [PMID: 32944247] (WB)
• Zou Y, Henry WS, Ricq EL et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion Nature 2020-09-01 [PMID: 32939090]
• Rogers MA, Buffolo F, Schlotter F et al. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis Science advances 2020-09-01 [PMID: 32938681] (WB, Human)
• Chu D, Nguyen A, Smith S et al. Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development Biol Open 2020-09-12 [PMID: 32917762]
• Giatromanolaki A, Kouroupi M, Pouliliou S et al. Ectonucleotidase CD73 and CD39 expression in non-small cell lung cancer relates to hypoxia and immunosuppressive pathways Life Sci. 2020-09-06 [PMID: 32898522] (WB, Human)
• Chao CT, Yeh HY, Tsai YT et Al. A combined microRNA and target protein-based panel for predicting the probability and severity of uraemic vascular calcification: a translational study Cardiovasc Res 2022-02-07 [PMID: 32866261] (Western Blot)
• Gao N, Zhao K, Cao Y et al. A role of lamin A/C in preventing neuromuscular junction decline in mice J. Neurosci. 2020-08-17 [PMID: 32817327] (WB)
• Varela FA, Foust VL, Hyland TE et al. TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer Sci Rep 2020-08-17 [PMID: 32807808] (WB, Mouse)
• Park HJ, Jo DS, Choi DS et al. Ursolic acid inhibits pigmentation by increasing melanosomal autophagy in B16F1 cells Biochem. Biophys. Res. Commun. 2020-08-10 [PMID: 32792197] (WB, Mouse)
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• Lee JY, Fan CC, Chou NL et al. PHRF1 promotes migration and invasion by modulating ZEB1 expression PLoS ONE 2020-07-30 [PMID: 32730336] (IHC-P, Human)
• Cinque L, De Leonibus C, Iavazzo M et al. MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B EMBO J. 2020-09-01 [PMID: 32716134] (WB, Mouse)
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• La Fuente JM, Sevilleja-Ortiz A, Garcia-Rojo E et al. Erectile dysfunction is associated with defective L-cysteine/hydrogen sulfide pathway in human corpus cavernosum and penile arteries Eur. J. Pharmacol. 2020-07-23 [PMID: 32712093] (WB, Human)
  
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• Karbowski, C, Goldstein, R Et al. Nonclinical Safety Assessment of AMG 553, an Investigational Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Acute Myeloid Leukemia. Toxicol Sci 2020-09-01 [PMID: 32589753] (IF/IHC, Human)
• Alicea GM Metabolic Consequences of an Aging Microenvironment in Melanoma Thesis Jan 1 2020 (WB, Human, Mouse)
• Chi TH, Hsieh BY, Liang PS et al. Expression and Functional Study of Single Mutations of Carbonic Anhydrase 8 in Neuronal Cells Cell. Mol. Neurobiol. 2020-06-24 [PMID: 32583043]
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• Khodja Y, Samuels ME Ethanol-mediated upregulation of APOA1 gene expression in HepG2 cells is independent of de novo lipid biosynthesis Lipids Health Dis 2020-06-20 [PMID: 32563265] (WB, Human)
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• Hsieh M, Hsieh M, Lo Y et al. Modulating effect of Coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway Biomedicine & Pharmacotherapy 2020-08-01 [PMID: 32502840] (WB, Human)
• Alicea GM, Rebecca VW, Goldman AR et al. Changes in Aged Fibroblast Lipid Metabolism Induce Age-dependent Melanoma Cell Resistance to Targeted Therapy Via the Fatty Acid Transporter FATP2 Cancer Discov 2020-06-04 [PMID: 32499221]
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• Jin Y, Shen Y, Su X et al. The Small GTPases Rab27b Regulates Mitochondrial Fatty Acid Oxidative Metabolism of Cardiac Mesenchymal Stem Cells Front Cell Dev Biol 2020-04-15 [PMID: 32351955] (WB, Mouse)
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• Li R, Li X, Hagood J et al. Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface J. Clin. Invest. 2020-04-27 [PMID: 32338642] (WB, Mouse)
• Anna Laitakari, Joona Tapio, Kari A. Mäkelä, Karl-Heinz Herzig, Franziska Dengler, Helena Gylling, Gail Walkinshaw, Johanna Myllyharju, Elitsa Y. Dimova, Raisa Serpi, Peppi Koivunen HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD Journal of Molecular Medicine (Berlin, Germany) 2020-04-15 [PMID: 32296880]
• Lieberman O J, Cartocci V et al. mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders. Front Cell Neurosci 2020-04-17 [PMID: 32296308] (WB, Mouse)
• Romeo MA, Gilardini Montani MS, Benedetti R et al. PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR Biomolecules 2020-04-10 [PMID: 32290231]
• Murthi P, Rajaraman G et al. Decreased Placental FPR2 in Early Pregnancies That Later Developed Small-For-Gestation Age: A Potential Role of FPR2 in the Regulation of Epithelial-Mesenchymal Transition. Cells 2020-10-04 [PMID: 32290034] (WB, Human)
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• Lin Jh, Chen Sy, Lu Cc et Al. Ursolic acid promotes apoptosis, autophagy, and chemosensitivity in gemcitabine-resistant human pancreatic cancer cells Phytother Res 2020-03-17 [PMID: 32185829] (WB)
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• Wu PK, Wang JY, Chen CF et al. Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity. Stem Cells Transl Med 2017-06-01 [PMID: 28544661] (WB, Human)
• Balbaa M, Abdulmalek SA, Khalil S. Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs. PLoS ONE 2017-05-15 [PMID: 28505155] (WB, Rat)
• Neuhaus J, Schiffer E et al. Protease Expression Levels in Prostate Cancer Tissue Can Explain Prostate Cancer-Associated Seminal Biomarkers-An Explorative Concept Study. Int J Mol Sci 2017-04-05 [PMID: 28471417] (WB, Human)
• Pettersson H, Zarnegar B, Westin A et al. SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo. Sci Rep 2017-04-24 [PMID: 28439090] (WB, Mouse)
• Wang X, Dasari S, Nowakowski GS et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget 2017-04-18 [PMID: 28412739] (WB, Human)
• Ho TJ, Lee CW, Lu ZY et al. Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice. Evid Based Complement Alternat Med 2017-03-16 [PMID: 28400844] (WB, Mouse)
• Lee YS, Kim JY, Oh KS, Chung SW. Fatty acid-binding protein 4 regulates fatty infiltration after rotator cuff tear by hypoxia-inducible factor 1 in mice. J Cachexia Sarcopenia Muscle. 2017-04-05 [PMID: 28382782] (WB, Mouse)
• Raats DA, Frenkel N, van Schelven SJ et al. CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage. Cell Death Dis. 2017-03-16 [PMID: 28300842] (WB, Human)
• Piccolo P, Annunziata P, Soria LR et al. Downregulation of HNF-4a and defective zonation in livers expressing mutant Z a1-antitrypsin.. Hepatology. 2017-03-15 [PMID: 28295475] (IF/IHC, Mouse)
• Chen KC, Hsieh MS, Li YR et al. Study of poly-e-caprolactone membranes for pleurodesis. J. Formos. Med. Assoc. 2017-02-16 [PMID: 28215672] (WB, Rabbit)
• Bilodeau S, Caron V, Gagnon J et al. A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR J Mol Cell Biol 2017-06-01 [PMID: 28201649] (WB, Human)
• Giatromanolaki A, Liousia M, Arelaki S et al. Differential effect of hypoxia and acidity on lung cancer cell and fibroblast metabolism. Biochemistry and Cell Biology. 2017-01-24 [PMID: 28177758] (WB)
• Wang X, Boddicker RL, Dasari S et al. Expression of p63 protein in anaplastic large cell lymphoma: Implications for genetic subtyping. Hum. Pathol. 2017-01-30 [PMID: 28153507] (WB)
• Sansone C, Galasso C, Orefice I et al. The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells Sci Rep 2017-01-24 [PMID: 28117410] (WB, Human)
• Pereira ML, Ortolan LS, Sercundes MK et al. Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS Mediators Inflamm. 2016-11-14 [PMID: 27974865] (WB, Mouse)
• Abdelbaset-Ismail Ahmed, Pedziwiatr Daniel, Schneider Gabriela et al. Pituitary sex hormones enhance the pro-metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase-1 International Journal of Oncology 2017-01-01 [PMID: 27922667] (WB, Mouse)
• Lin YC, Chao TY, Yeh CT et al. Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis. Arterioscler. Thromb. Vasc. Biol. 2016-11-10 [PMID: 27834687]
• Chen HR, Yeh YC, Liu CY et al. DDR1 promotes E-cadherin stability via inhibition of integrin-beta1-Src activation-mediated E-cadherin endocytosis. Sci Rep. 2016-11-08 [PMID: 27824116] (WB, Canine)
• Getun IV, Wu Z, Fallahi M et al. Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hotspots. Mol. Cell. Biol. 2016-11-07 [PMID: 27821479] (WB, Mouse)
• Patterson B A, Matarneh S K et al. Pectoralis major muscle of turkey displays divergent function as correlated with meat quality. Poult Sci 2017-01-05 [PMID: 27816932] (WB, Turkey)
  
  Details:
  Meleagris gallopavo (Turkey)
• Iwata H, Goettsch C, Sharma A et al. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016-10-31 [PMID: 27796300] (WB, Mouse)
• Zhou TE, Rivera JC, Bhosle VK et al. Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1B. Am. J. Pathol. 2016-10-18 [PMID: 27768863] (WB)
• Di K, Lomeli N, Wood SD et al. Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma. Oncotarget. 2016-11-22 [PMID: 27764809] (WB, Human)
• Pradhan S, Mahajan D, Kaur P et al. Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Oncotarget. 2016-11-01 [PMID: 27708247] (ICC/IF, Human)
• Kao T, Labonne T, Niclis JC et Al. GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives Stem Cell Reports 2016-09-01 [PMID: 27594589] (Western Blot)
• Hu Y, Su H, Liu C et al. DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia. Oncogene 2016-09-05 [PMID: 27593934] (WB)
• Erdogan S, Doganlar O, Doganlar ZB et al. The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-kB signaling. Life Sci. 2016-08-25 [PMID: 27569589] (WB)
• Yoon H, Scarisbrick IA. Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis. Biol. Chem. 2016-08-17 [PMID: 27533119]
• Vanas V, Haigl B, Stockhammer V, Sutterluty-Fall H. MicroRNA-21 Increases Proliferation and Cisplatin Sensitivity of Osteosarcoma-Derived Cells. PLoS ONE. 2016-08-12 [PMID: 27513462] (WB)
• Leinonen H, Rossi M, Salo AM et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum. Mol. Genet. 2016-07-27 [PMID: 27466183] (WB, Mouse)
• Sato T, Ito Y, Nagasawa T. Regulatory effects of the L-lysine metabolites, L-2-aminoadipic acid and L-pipecolic acid, on protein turnover in C2C12 myotubes Biosci. Biotechnol. Biochem. 2016-07-18 [PMID: 27427787]
• Wong AY, Hristova E, Ahlskog N et al. ABERRANT SUBCELLULAR DYNAMICS OF SIGMA-1 RECEPTOR MUTANTS UNDERLYING NEUROMUSCULAR DISEASES Mol. Pharmacol. 2016-07-14 [PMID: 27418673] (WB, Human)
• Ekser B, Mangus RS, Kubal CA et al. Recurrence of Hyperoxaluria and Kidney Disease after Combined Intestine-Kidney Transplantation for Enteric Hyperoxaluria Am. J. Nephrol. 2016-07-14 [PMID: 27410399] (WB, Mouse)
• Baradaran-Heravi Alireza, Balgi Aruna D, Zimmerman Carla et al. Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. Nucleic Acids Research 2016-01-01 [PMID: 27407112] (WB, Human)
• Lee MC, Huang HJ, Chang TH et al. Genome-wide analysis of HIF-2alpha chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep 2016-07-04 [PMID: 27373565] (WB)
• Xu Y, Li F, Zalzala M et al. Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice Hepatology 2016-06-30 [PMID: 27359351] (WB)
• Goettsch C, Hutcheson JD, Hagita S et al. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis 2016-06-09 [PMID: 27318830] (WB, Mouse)
• Boddicker R L, Razidlo G L et al. Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma. Blood 2016-01-09 [PMID: 27297792] (WB, Human)
• Tsai WL, Yeh PH, Tsai CY et al. Efficient programming of human mesenchymal stem cell-derived hepatocytes by epigenetic regulations. J Gastroenterol Hepatol 2016-05-24 [PMID: 27218433] (WB, Human)
• Bhoopathi P, Lee N, Pradhan AK et al. mda-7/IL-24 induces cell death in neuroblastoma through a novel mechanism involving AIF and ATM. Cancer Research. 2016-04-13 [PMID: 27197168] (WB, Human)
  
  Details:
  Beta actin antibody was used for Western blot application in experiments involving human neuroblastoma cancer cell lines namely SK-N-AS, SK-NSH and NB1691.
• Pastore N, Brady OA, Diab HI et al. TFEB and TFE3 Cooperate in the Regulation of the Innate Immune Response in Activated Macrophages. Autophagy. 2016-05-12 [PMID: 27171064] (WB, Mouse)
• Liao ML, Peng WH, Kan D, Chien CL. et Al. Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina J Comp Neurol 2016-05-10 [PMID: 27159642]
• Radulovic M, Yoon H, Wu J et al. Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury. Neurobiol. Dis. 2016-05-01 [PMID: 27145117] (WB, Mouse)
• Boothe T, Lim GE, Cen H et al. Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab 2016-05-01 [PMID: 27110488] (WB)
• Lai CW, Chen HL, Tsai TC et al. Sexually Dimorphic Expression of eGFP Transgene in the Akr1A1 Locus of Mouse Liver Regulated by Sex Hormone-Related Epigenetic Remodeling. Sci Rep. 2016-04-18 [PMID: 27087367] (WB, Mouse)
• Xu J, Xu Y, Li Y et al. Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury. Sci Rep. 2016-04-14 [PMID: 27075303] (WB, Mouse)
• Acharya M, Sokolovska A, Tam JM et al. alphav Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016-03-11 [PMID: 26965188] (WB, Mouse)
• Naik E, Dixit VM. Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCbeta Kinase Activity. J. Immunol. 2016-03-02 [PMID: 26936881] (WB, Mouse)
  
  Details:
  GPR78 antibody was used for WB analysis of lysates from skin fibroblasts of Homocystinuria Patients with Remethylation Defects and control subjects. WB was also performed on lysates from cells treated or not with tunicamycin (Fig 1).
• Hong MN, Nam KY, Kim KK et al. The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones 2016-05-01 [PMID: 26873011]
• Andreev E, Brosseau N, Carmona E et al. The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin Sci Rep 2016-02-10 [PMID: 26861753] (WB, Human)
• Gosejacob D, Jager PS, Vom Dorp K et al. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J. Biol. Chem. 2016-03-25 [PMID: 26853464] (WB, ELISA, Mouse)
• Rahtu-Korpela L, Maatta J et al. Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis. Arterioscler Thromb Vasc Biol 2016-01-04 [PMID: 26848160] (WB, Mouse)
• Yoon H, Kleven A, Paulsen A et al. Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system Biochim. Biophys. Acta 2016-01-26 [PMID: 26826016] (WB, Mouse)
• Maj M, Hoermann G, Rasul S et al. The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells. J Diabetes Res 2016-01-01 [PMID: 26824039] (WB)
• Westwell-Roper C, Denroche HC, Ehses JA, Verchere CB et al. Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates J. Biol. Chem. 2016-01-19 [PMID: 26786104] (WB, Mouse)
• Bohnsack JP, Carlson SL, Morrow AL. Differential regulation of synaptic and extrasynaptic alpha4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons. Neuropharmacology 2016-06-01 [PMID: 26767953]
• Davis SM, Collier LA, Leonardo CC et al. Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3. Mol. Neurobiol. 2016-01-09 [PMID: 26746670] (WB, Rat)
• Lee SB, Frattini V, Bansal M et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016-01-14 [PMID: 26735018] (WB, Human)
• Cerqueira FM, Chausse B, Baranovski BM et al. Diluted Sera From Calorie Restricted Animals Promote Mitochondrial Beta-Cell Adaptations and Protect Against Glucolipotoxicity. FEBS J. 2016-01-06 [PMID: 26732506] (WB, Rat)
  
  Details:
  Beta-Actin antibody used for WB as a loading control on serum from AL and CR rats at a dilution of 1:2000 (Figure 3A).
• Lee KC, Hsieh YC, Yang YY et al. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. Sci Rep 2016-01-06 [PMID: 26732252] (WB)
• Kral R, Doriguzzi A, Mayer CE et al. Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells. J. Cell. Biochem. 2016-01-05 [PMID: 26727965] (WB, Human)
  
  Details:
  Beta-Actin antibody used as a loading control for WB on WI-38, A549 and VL-8 cells that were infected with adenoviruses (Figure 1A).
• Yu CY, Liang JJ, Li JK et al. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog. 2015-12-01 [PMID: 26717518] (WB, Human)
• Wang TK, Lin YM, Lo CM et al. Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells. Tumour Biol. 2015-12-28 [PMID: 26711783] (WB, Human)
  
  Details:
  beta-Actin antibody (clone AC-15) was used for WB assays in experiments involving human osteosarcoma cell lines MG-63, U-2 OS, HOS and 143B and human embryonic kidney cell line HEK293.
• Laukka T, Mariani CJ, Ihantola T et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem 2016-02-19 [PMID: 26703470]
• Vannuvel K, Van Steenbrugge M, Demazy C et al. Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population. J. Cell. Physiol. 2015-12-17 [PMID: 26680008] (WB, Human)
• Sorrentino NC, Maffia V, Strollo S et al. A Comprehensive Map of CNS Transduction by Eight Recombinant Adeno-associated Virus Serotypes Upon Cerebrospinal Fluid Administration in Pigs. Mol. Ther. 2015-12-07 [PMID: 26639405] (WB, Porcine)
• Suriben R, Kaihara KA, Paolino M et al. beta-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1. Cell. 2015-12-03 [PMID: 26627735] (WB, Mouse)
• Yang Y, Jin Y, Du W. Programmed cell death 2 functions as a tumor suppressor in osteosarcoma. Int J Clin Exp Pathol. 2015-11-30 [PMID: 26617804] (WB, Rat)
• Fossati Silvia, Giannoni Patrizia, Solesio Maria E et al. The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain Neurobiol Dis 2016-02-01 [PMID: 26581638] (WB, Mouse)
  
  Details:
  Citation using the Purified form of this antibody.
• Cheng YF, Young GH, Lin JT et al. Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells. PLoS ONE. 2015-11-07 [PMID: 26544976] (WB, Human)
• Lin CL, Cheng YS, Li HH et al. Amyloid-beta suppresses AMP-activated protein kinase (AMPK) signaling and contributes to alpha-synuclein-induced cytotoxicity. Exp Neurol 2016-01-01 [PMID: 26515689]
• Lin CW, Chen YS, Lin CC et al. Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy. Sci Rep. 2015-10-30 [PMID: 26515640] (WB, Mouse)
• Weng WH, Leung WH, Pang YJ, Hsu HH Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression. Oncol Rep 2016-01-01 [PMID: 26496897]
• Karsikas S, Myllymaki M, Heikkila M et al. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med (Berl) 2016-03-01 [PMID: 26452676]
• Shi C, Huang X, Zhang B et al. The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. PLoS One 2015-01-01 [PMID: 26414348] (Chemotaxis)
• Qiu Q, Yang C, Xiong W et al. SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells. Apoptosis 2015-12-01 [PMID: 26404525] (Human)
• Cox JV, Abdelrahman YM, Peters J et al. Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth Cell Microbiol. 2016-03-18 [PMID: 26381674] (WB, Human)
  
  Details:
  Citation using the Purified form of this antibody.
• Koukourakis MI, Kalamida D, Giatromanolaki A et al. Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines. PLoS One 2015-01-01 [PMID: 26378792] (WB, Human)
• Sato T, Ito Y, Nagasawa T. Dietary l-Lysine Suppresses Autophagic Proteolysis and Stimulates Akt/mTOR Signaling in the Skeletal Muscle of Rats Fed a Low-Protein Diet. J. Agric. Food Chem. 2015-09-23 [PMID: 26366928] (WB, Rat)
• Wu L, Zhang Z, Pan X et al. Expression and contribution of the HIF-1 alpha/VEGF signaling pathway to luteal development and function in pregnant rats Mol Med Rep 2015-09-02 [PMID: 26323652] (Rat)
• Radulovic M, Yoon H, Wu J et al. Genetic Targeting of Protease Activated Receptor 2 Reduces Inflammatory Astrogliosis and Improves Recovery of Function after Spinal Cord Injury. Neurobiol. Dis. 2015-08-24 [PMID: 26316358] (WB, Mouse)
• Sato T, Ito Y, Nagasawa T. Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine. Mol. Cell. Biochem. 2015-08-26 [PMID: 26307368] (WB, Mouse)
• Lin CL, Huang WN, Li HH et al. Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chem. Biol. Interact. 2015-08-10 [PMID: 26271894] (WB, Human)
  
  Details:
  beta-Actin antibody was used for WB analysis of lysates from human neuroblastoma SK-N-MC cells that were subjected to treatments with Amyloid beta and / or hydrogen-rich water in vitro.
• Juhasz T, Szentleleky E, Somogyi CS et al. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures. Int J Mol Sci. 2015-08-03 [PMID: 26230691] (WB, Chicken)
  
  Details:
  Collagen II antibody (clone 5B2.5) was used at 1:100 dilution for WB analysis of lysates from experiments involving chondrifying primary micromass cell cultures that were established from chicken embryos (Ross hybrid) of Hamburger-Hamilton stages 22–24. The cultures were treated or not with Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) PACAP 1–38 and/or transient MS.
• Lim GE, Albrecht T, Piske M et al. 14-3-3zeta coordinates adipogenesis of visceral fat. Nat Commun 2015-01-01 [PMID: 26220403] (IP)
• Bamidele AO, Kremer KN, Hirsova P et al. IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes J. Cell Biol. 2015-07-20 [PMID: 26195666] (WB, Human)
• Lin CW Jan MS Kuo JH. Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. Mol Pharm. [PMID: 26158199]
• Yang C, Fischer-Keso R, Schlechter T et al. Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression Tumour Biol. 2015-07-04 [PMID: 26138584] (WB, Human)
• Sasaki Y, Ohta M, Desai D et al. Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance PLoS ONE. 2015-07-03 [PMID: 26132105] (WB, Human, Mouse)
• Yang JS, Lin CW, Chuang CY et al. Carbonic anhydrase IX overexpression regulates the migration and progression in oral squamous cell carcinoma Tumour Biol. 2015-07-01 [PMID: 26130414] (WB, Human)
• Smith BW, Simpson DG, Miller RJ et al. Contrast Ultrasound Imaging Does Not Affect Heat Shock Protein 70 Expression in Cholesterol-Fed Rabbit Aorta J Ultrasound Med. 2015-07-01 [PMID: 26112623] (WB, Rabbit)
• Miki Y, Akimoto J, Moritake K et al. Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells Lasers Med Sci. 2015-06-25 [PMID: 26109138] (WB, Human)
• Chang CJ, Lin CS, Lu CC et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun 2015-01-01 [PMID: 26102296] (Mouse)
• Xu Y, Zalzala M, Xu J et al. A metabolic stress-inducible miR-34a-HNF4a pathway regulates lipid and lipoprotein metabolism Nat Commun 2015-06-23 [PMID: 26100857] (WB, Mouse)
• Billeter AT, Galbraith N, Walker S et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response Surgery. 2015-06-05 [PMID: 26054320] (WB, Human)
• Viale-Bouroncle S, Klingelhoffer C, Ettl T, Morsczeck C. The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells. Mol. Cell. Biochem. 2015-05-16 [PMID: 25981531] (WB, Human)
• Pang X, Wang Z, Yin D, Zhang Z. Overexpression of hypoxia-inducible factor prolyl- hydoxylase attenuated by HCG-induced vascular endothelial growth factor expression in luteal cells. Mol Med Rep 2015-05-16 [PMID: 25975603]
• Li HH, Lu FJ, Hung HC et al. Humic Acid Increases Amyloid beta-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells.. Int J Mol Sci. 2015-05-07 [PMID: 25961951]
• Doriguzzi A, Haigl B, Gsur A, Sutterluty-Fall H. The increased Sprouty4 expression in response to serum is transcriptionally controlled by Specific protein 1. Int. J. Biochem. Cell Biol. 2015-05-06 [PMID: 25957915] (WB, Human)
• Wang ML, Lin SH, Hou YY, Chen YH. alpha-Naphthoflavone Increases Lipid Accumulation in Mature Adipocytes and Enhances Adipocyte-Stimulated Endothelial Tube Formation. Nutrients. 2015-05-06 [PMID: 25942489] (WB, Human)
• Yen JH, Lin LC, Chen MC, Sarang Z. The metastatic tumor antigen 1-transglutaminase-2 pathway is involved in selflimitationof monosodiumurate crystal-induced inflammation byupregulating TGF-beta1 Arthritis Research & Therapy 2015-02-26 [PMID: 25889736] (WB, Mouse, Human)
• Kao YT, Chang BL, Liang JJ et al. Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid beta-Oxidation PLoS Pathog. 2015-03-01 [PMID: 25816318] (WB, Human)
• Shaw D, Wang X, Brown L et al. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. [PMID: 25790189]
• Matteucci C, Minutolo A, Marino-Merlo F et al. Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB Life Sci. 2015-03-02 [PMID: 25744407] (WB, Human)
  
  Details:
  Beta-actin antibody was used as loading control for WB application in exeperiments involving AZT-induced NF-kB activation and its suppression by combined treatment with Bay-11-7085 in U937 cells (Fig. 2A).
• Wen J, Hanna CW, Martell S et al. Functional consequences of copy number variants in miscarriage Mol Cytogenet. 2015-02-12 [PMID: 25674159] (WB, Human)
• Capo-Chichi JM, Boissel S, Brustein E et al. Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria J. Med. Genet. 2015-02-03 [PMID: 25650066] (WB, Human, Zebrafish)
• Yoon H, Radulovic M, Drucker KL et al. The thrombin receptor is a critical extracellular switch controlling myelination Glia. 2015-01-27 [PMID: 25628003] (WB, Mouse)
• Chong KY, Hsu CJ, Hung TH et al. Wnt pathway activation and ABCB1 expression account for attenuation of Proteasome Inhibitor-mediated apoptosis in multidrug-resistant cancer cells Cancer Biol. Ther. 2015-01-15 [PMID: 25590413] (WB)
• Peng CC, Lin YT, Chen KC et al. Antrodan, A beta-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia.. Food Funct. 2015-02-11 [PMID: 25537160]
• Taher Chato, Frisk Gabriella, Fuentes Stina et al. High prevalence of human cytomegalovirus in brain metastases of patients with primary breast and colorectal cancers. Transl Oncol. 2014-12-01 [PMID: 25500083]
• Lin Sp, Chiu Fy, Wang Y et al. RB Maintains Quiescence and Prevents Premature Senescence through Upregulation of DnMT1 in Mesenchymal Stromal Cells. Stem Cell Reports. 2014-11-06 [PMID: 25455074] (WB, Human)
• Hsin Ch, Chen Mk, Tang Ch et al. High level of plasma matrix metalloproteinase-11 is associated with clinicopathological characteristics in patients with oral squamous cell carcinoma. PLoS OnE. 2014-11-26 [PMID: 25423087] (WB, Human)
• Pan Wr, Chen Yl, Hsu Hc,Chen Wj. Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy. Mol. Cell. Biochem. 2014-11-08 [PMID: 25380626] (WB, Human)
• Liu Y, Shim E, Crespo-Mejias Y et al. Cardiomyocytes are Protected from Antiretroviral nucleoside Analog-Induced Mitochondrial Toxicity by Overexpression of PGC-1Alpha Cardiovasc. Toxicol. 2014-11-07 [PMID: 25377427] (WB, Rat)
  
  Details:
  Beta actin antibody used for WB in experiments involving H9c2 cell line (derived from embryonic rat heart tissue).
• Chan Mt, Lim Ge, Skovso S et al. Effects of insulin on human pancreatic cancer progression modeled in vitro BMC Cancer et al. 2014-11-14 [PMID: 25373319] (WB, Human)
  
  Details:
  Beta actin antibody used as loading control for WB in experiments involving human primary pancreatic ductal cells, human HPDE cells and human PAnC1 cells.
• Lajud Sa, Nagda Da, Yamashita T et al. Dual Disruption of DnA Repair and Telomere Maintenance for the Treatment of Head and neck Cancer. Clin. Cancer Res. 2014-10-16 [PMID: 25324139] (WB, Human)
• Kokontis JM, Lin HP, Jiang SS et al. Androgen Suppresses the Proliferation of Androgen Receptor-Positive Castration-Resistant Prostate Cancer Cells via Inhibition of Cdk2, CyclinA, and Skp2. PLoS ONE. 2014-10-02 [PMID: 25271736] (WB, Human)
• Fischer-Keso R, Breuninger S, Hofmann S et al. Plakophilins 1 and 3 Bind to FXR1 and Thereby Influence the mRNA Stability of Desmosomal Proteins. Mol Cell Biol 2014-12-01 [PMID: 25225333]
• Naik E, Webster JD, DeVoss J et al. Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X. J Exp. Med. 2014-09-22 [PMID: 25200027] (WB, Mouse)
• Qin Q, Xie H, Wise SS et al. Homologous Recombination Repair Signaling in Chemical Carcinogenesis: Prolonged Particulate Hexavalent Chromium Exposure Suppresses the Rad51 Response in Human Lung Cells. Toxicol. Sci. 2014-08-30 [PMID: 25173789] (WB, Human)
• Yang NC, Song TY, Chang YZ et al. Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.. Biogerontology. 2015-02-01 [PMID: 25146190]
• Hung YW, Hung SW, Wu YC et al. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy Brain Behav. Immun. 2014-08-15 [PMID: 25135858]
• Dill-McFarland KA, Neil KL, Zeng A et al. Hibernation alters the diversity and composition of mucosa-associated bacteria while enhancing antimicrobial defense in the gut of 13-lined ground squirrels. Mol. Ecol. 2014-08-12 [PMID: 25130694] (WB, Mammal)
• Di K, Keir ST, Alexandru-Abrams D et al. Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models J. Neurooncol. 2014-08-13 [PMID: 25115740]
• Benayoun BA, Pollina EA, Ucar D et al. H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency Cell 2014-07-31 [PMID: 25083876]
• Lin CW, Jan MS, Kuo JH. Autophagy-related gene expression analysis of wild-type and atg5 gene knockout mouse embryonic fibroblast cells treated with polyethylenimine. Mol Pharm. 2014-09-02 [PMID: 25075440]
• Bohr M, Brooks AR, Kurtz CC. Hibernation induces immune changes in the lung of 13-lined ground squirrels (Ictidomys tridecemlineatus). Dev. Comp. Immunol. 2014-07-18 [PMID: 25046152] (WB, Squirrel)
  
  Details:
  Beta Actin antibody used as loading control for WB on lung of 13-lined ground squirrels (Ictidomys tridecemlineatus).
• Vande Walle Lieselotte, Van Opdenbosch Nina, Jacques Peggy et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature 2014-08-07 [PMID: 25043000] (WB, Mouse)
  
  Details:
  Using the HRP conjugated version of NB600-501, catalog number NB600-501H.
• Chen Chin-Chen, Lin Jiun-Tsai, Cheng Yi-Fang et al. Amelioration of LPS-induced inflammation response in microglia by AMPK activation. Biomed Res Int. 2014-06-17 [PMID: 25025067]
• Wu CM, Lin KW, Teng CH et al. Chalcone derivatives inhibit human platelet aggregation and inhibit growth in human bladder cancer cells. Biol. Pharm. Bull. 2014-07-03 [PMID: 24989010] (WB, Human)
  
  Details:
  Beta actin antibody used as a loading control in WB application in lysates of human bladder cancer cells NTUB1.
• Lin KW, Huang AM, Lin CC et al. Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer Eur. J. Pharmacol. 2014-06-14 [PMID: 24933647] (WB, Human)
  
  Details:
  Beta Actin antibody used as loading control in WB assays on NTUB1 (a human bladder carcinoma cell) treated or not with Ursolic acid derivative isopropyl 3beta-hydroxyurs-12-en-28-oat (UA17) and cisplatin combinations. WB Images - Fig. 3C, Fig. 10 B and C.
• Chung PJ, Chi LM, Chen CL et al. microRNA-205 targets tight junction-related proteins during urothelial cellular differentiation. Mol. Cell Proteomics. 2014-06-09 [PMID: 24912853] (WB, Mouse)
  
  Details:
  Beta Actin antibody used for WB in 550ug lysate of normal urothelial cells (isolated from mouse bladder) treated with the antogomir against miR-205 (antagomiR-205 or Ant-205) or scramble control.
• Rahtu-Korpela Lea, Karsikas Sara, Horkko Sohvi et al. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes. 2014-05-01 [PMID: 24789921] (Mouse)
• Press T, Viale-Bouroncle S, Felthaus O et al. EGR1 supports the osteogenic differentiation of dental stem cells. Int Endod J 2014-04-21 [PMID: 24749562] (WB, Human)
• Zeng W, Guo YH, Qi W et al. 4-Phenylbutyric acid suppresses inflammation through regulation of endoplasmic reticulum stress of endothelial cells stimulated by uremic serum. Life Sci. 2014-03-17 [PMID: 24650493] (WB, Human)
• Wong TW, Doyle AD, Lee JJ, Jelinek DF. Eosinophils Regulate Peripheral B Cell Numbers in Both Mice and Humans. J. Immunol. 2014-03-10 [PMID: 24616476] (WB, Human)
• Cai B, Xie S, Liu F et al. Rapid Degradation of the Complement Regulator, CD59, by a Novel Inhibitor. J. Biol. Chem. 2014-03-10 [PMID: 24616098] (WB, Human)
• Liu Y, Shim E, Nguyen P et al. Tempol Protects Cardiomyocytes from Nucleoside Reverse Transcriptase Inhibitor-Induced Mitochondrial Toxicity. Toxicol. Sci. 2014-03-10 [PMID: 24591154] (WB, Rat)
• Xia S Function and mechanism of the gasdermin family Thesis 2021-01-01 (WB, Mouse)
• Brugger D, Buffler M, Windisch W. Development of an experimental model to assess the bioavailability of zinc in practical piglet diets. Arch Anim Nutr 2014-04-01 [PMID: 24646148] (WB, Porcine)
  
  Details:
  Using the HRP conjugated version of NB600-501, catalog number NB600-501H.
• Hung TM, Ho CM, Liu YC et al. Up-Regulation of MicroRNA-190b Plays a Role for Decreased IGF-1 That Induces Insulin Resistance in Human Hepatocellular Carcinoma. PLoS ONE 2014-03-03 [PMID: 24586785] (WB, Human)
• Chowdhury, A Tamalin/GRAS-1 Connects Glutamate Receptor Activity to the Insulin/IGF Signaling Cascade to Regulate Neuroprotection in a Nematode Model of Excitotoxicity Thesis 2020-01-01 (WB, C. elegans)
• Herbst C, Bothe V, Wegler M et al. Heterozygous loss-of function variants in DOCK4 cause neurodevelopmental delay and microcephaly Research Square 2023-11-14
• Zheng Xiaoxu, Heaps Cristine L, Fisher Steven A. Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion. Microvasc Res. 2014-01-01 [PMID: 24534069] (Bovine)
• Van Opdenbosch Nina, Gurung Prajwal, Vande Walle Lieselotte et al. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun 2014-01-01 [PMID: 24492532] (WB)
  
  Details:
  Using the HRP conjugated version of NB600-501, catalog number NB600-501H.
• Liang JJ, Wei JC, Lee YL et al. Surfactant-modified nanoclay exhibits an antiviral activity with high potency and broad spectrum. J. Virol. 2014-01-30 [PMID: 24478435] (WB, Hamster, Human)
• Yu CH, Yu CC. Photodynamic therapy with 5-aminolevulinic acid (ALA) impairs tumor initiating and chemo-resistance property in head and neck cancer-derived cancer stem cells. PLoS ONE 2014-01-29 [PMID: 24475244] (WB, Human)
• D'souza AM, Asadi A, Johnson JD, Kieffer TJ. Leptin Deficiency in Rats Results in Hyperinsulinemia and Impaired Glucose Homeostasis. Endocrinology 2014-01-28 [PMID: 24467741] (WB, Rat)
• Kaczmarek MZ, Holland RJ, Lavanier SA et al. Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells. Leuk Res 2013-12-12 [PMID: 24461365] (WB, Mouse)
• Li KW, Yu YP, Zhou C et al. Calcium channel alpha-2-delta1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. J. Biol. Chem. 2014-01-24 [PMID: 24459143] (WB, Rat)
• Schusser B, Yi H, Collarini EJ et al. Harnessing Gene Conversion in Chicken B Cells to Create a Human Antibody Sequence Repertoire. PLoS One. 2013-11-21 [PMID: 24278246] (WB, Chicken)
• Zhou C, Luo ZD. Electrophysiological characterization of spinal neuron sensitization by elevated calcium channel alpha-2-delta-1 subunit protein. Eur J Pain. 2013-10-23 [PMID: 24151064]
• Thies HW, Nolte I, Wenk H et al. Permanent activation of HMGA2 in lipomas mimics its temporal physiological activation linked to the gain of adipose tissue. Obesity (Silver Spring). 2012-11-06 [PMID: 24106133] (WB, Human, Canine)
• Carmony KC. Elucidating Proteasome Catalytic Subunit Composition and Its Role in Proteasome Inhibitor Resistance. Thesis. 2016-04-18 (WB, Human)
• Lin HP, Lin CY, Hsiao PH et al. Difference in Protein Expression Profile and Chemotherapy Drugs Response of Different Progression Stages of LNCaP Sublines and Other Human Prostate Cancer Cells. PLoS One 2013-12-05 [PMID: 24349321] (WB, Human)
• Zhu M, Guo M, Fei L et al. 4-Phenylbutyric acid attenuates endoplasmic reticulum stress-mediated pancreatic beta-cell apoptosis in rats with streptozotocin-induced diabetes. Endocrine 2013-12-18 [PMID: 24347242] (WB, Rat)
• Viale-Bouroncle S, Gosau M, Morsczeck C. NOTCH1 signaling regulates the BMP2/DLX-3 directed osteogenic differentiation of dental follicle cells. Biochem Biophys Res Commun. 2013-12-07 [PMID: 24321094] (WB, Human)
• Gini B, Zanca C, Guo D et al. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res 2013-10-15 [PMID: 24030701]
• Su S, Chen Y, Chien C et al. PDIA4: A Novel ER Stress Protein Regulating Hepatic Lipogenesis in Non-Alcoholic Fatty Liver Disease Research Square 2023-06-13 (Western Blot, Human)
• Govaert KM, Emmink BL, Nijkamp MW et al. Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells. Ann Surg 2013-11-18 [PMID: 24253142] (WB, Mouse)
• Xu J, Li Y, Chen WD et al. Hepatic carboxylesterase 1 Is essential for both normal and farnesoid X receptor-controlled lipid homeostasis. Hepatology. 2013-08-28 [PMID: 24038130] (WB, Mouse)
• Douglas CR LonP1 as a Key Driver of Tumor Progression and a Therapeutic Target in IDH Mutant Astrocytoma Thesis 2023-01-01 (WB, Human)
• Campbell T, Slone J, Metzger H et al. Clinical study of FDXR-related mitochondriopathy: genotype-phenotype correlation and proposal of ancestry-based carrier screening in the Mexican population Genetics in Medicine Open 2023-11-01 (WB, Human)
• Mounce BC, Mboko WP, Kanack AJ et al. Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection. J. Virol. 2014-02-01 [PMID: 24335310] (WB, Mouse)
• Allache R, Lachance S, Guyot MC et al. Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway. Hum Mol Genet. 2013-11-18 [PMID: 24203697] (WB, Human)
• Li KW, Kim DS, Zaucke F et al. Trigeminal nerve injury-induced thrombospondin-4 up-regulation contributes to orofacial neuropathic pain states in a rat model. Eur J Pain. 2013-09-09 [PMID: 24019258]
• Snoeren N, Emmink BL, Koerkamp MJ et al. Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer. Br J Cancer. 2013-09-17 [PMID: 24002600] (WB, Human)
• Feldman AL, Vasmatzis G, Asmann YW et al. Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma. Genes Chromosomes Cancer. 2013-09-02 [PMID: 23999969] (WB, Human)
• Chan CC, Lee KC, Huang YH et al. Regulation by Resveratrol of the Cellular Factors Mediating Liver Damage and Regeneration after Acute Toxic Liver Injury. J Gastroenterol Hepatol. 2013-08-23 [PMID: 23981054] (WB, Mouse)
• Khan Z, Yaiw KC, Wilhelmi V et al. Human cytomegalovirus immediate early proteins promote degradation of connexin 43 and disrupt gap junction communication: implications for a role in gliomagenesis. Carcinogenesis 2014-01-01 [PMID: 23978378]
• Liu L, Martin R, Kohler G, Chan C. Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes. Exp Neurol 2013-10-01 [PMID: 23968646] (WB, Rat)
  
  Details:
  Using the HRP conjugated version of NB600-501, catalog number NB600-501H.
• Chang KP, Wang CL, Kao HK et al. Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma. Cancer. 2013-08-20 [PMID: 23963810] (WB, Human)
• Hsu PK, Chen HY, Yeh YC et al. TPX2 expression is associated with cell proliferation and patient outcome in esophageal squamous cell carcinoma. J Gastroenterol. 2013-08-21 [PMID: 23963785] (WB, Human)
• Lee CC, Lai YT, Chang HT et al. Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma. Biochem Pharmacol. 2013-08-12 [PMID: 23948063] (WB, Mouse)
• Yeh CN, Chiang KC, Juang HH et al. Reappraisal of the Therapeutic Role of Celecoxib in Cholangiocarcinoma. PLoS One 2013-07-26 [PMID: 23922859] (WB, Rat)
• Hsieh YT, Chou MM, Chen HC, Tseng JJ. IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1. Gynecol Oncol. 2013-10-01 [PMID: 23911878]
• Morel E, Chamoun Z, Lasiecka ZM et al. Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun 2013-08-02 [PMID: 23907271] (WB, Human)
• Tigrine C, Bulzomi P, Leone S et al. Cleome arabica leaf extract has anticancer properties in Human cancer cells. Pharm Biol 2013-07-18 [PMID: 23862683] (WB, Human)
• Wen J, Lopes F, Soares G et al. Phenotypic and functional consequences of haploinsufficiency of genes from exocyst and retinoic acid pathway due to a recurrent microdeletion of 2p13.2. Orphanet J Rare Dis 2013-07-10 [PMID: 23837398] (WB, Human)
• Emmink BL, Verheem A, Van Houdt WJ et al. The secretome of colon cancer stem cells contains drug-metabolizing enzymes. J Proteomics 2013-07-05 [PMID: 23835434] (WB, Human)
• Rathmanner N, Haigl B, Vanas V et al. Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells. FEBS Lett 2013-07-04 [PMID: 23831057] (WB, Human)
• Kremer KN, Peterson KL, Schneider PA et al. SDF-1/CXCR4 signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. J Biol Chem 2013-06-24 [PMID: 23798675] (WB, Human)
• Ko CH, Cheng CF, Lai CP et al. Differential proteomic analysis of cancer stem cell properties in hepatocellular carcinomas by isobaric tag labeling and mass spectrometry. J Proteome Res 2013-08-02 [PMID: 23782096] (WB, Human)
• Shie MY, Ding SJ. Integrin binding and MAPK signal pathways in primary cell responses to surface chemistry of calcium silicate cements. Biomaterials 2013-09-01 [PMID: 23768900] (ELISA, Human)
• Liu T, Zhang S, Xiang D, Wang Y. Induction of hepatocyte-like cells from mouse embryonic stem cells by lentivirus-mediated constitutive expression of Foxa2/Hnf4a. J Cell Biochem 2013-06-06 [PMID: 23744720] (WB, Mouse)
• Babic I, Anderson ES, Tanaka K et al. EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer. Cell Metab 2013-06-04 [PMID: 23707073] (WB, Human)
• Formosa R, Xuereb-Anastasi A, Vassallo J. AIP regulates cAMP signalling and growth hormone secretion in GH3 cells. Endocr Relat Cancer 2013-05-23 [PMID: 23702468] (ICC/IF, WB, Rat)
• Das I, Png CW, Oancea I et al. Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med 2013-05-06 [PMID: 23650437] (WB, Human)
• Zeng J, Kim D, Li KW et al. Thrombospondin-4 contributes to spinal cord injury-induced changes in nociception. Eur J Pain 2013-05-07 [PMID: 23649982]
• Yoon H, Radulovic M, Wu J et al. Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. J Neurochem. 2013-10-01 [PMID: 23647384] (WB, IP, Mouse)
• Rafalski VA, Ho PP, Brett JO et al. Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.. Nat Cell Biol 2013-06-01 [PMID: 23644469] (WB, Mouse)
• Cai H, Peng F. Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells. Oncol Rep 2013-07-01 [PMID: 23624903]
• Kral RM, Mayer CE, Vanas V et al. In non-small cell lung cancer mitogenic signaling leaves Sprouty1 protein levels unaffected. Cell Biochem Funct 2013-04-24 [PMID: 23616430] (WB, Human)
• Huang TT, Chong KY, Ojcius DM et al. Hirsutella sinensis mycelium suppresses interleukin-1beta and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. Sci Rep 2013-03-05 [PMID: 23459183] (WB, Human)
• Park Y, Carr TPet al. Unsaturated fatty acids and phytosterols regulate cholesterol transporter genes in Caco-2 and HepG2 cell lines. Nutr Res. 2013-02-01 [PMID: 23399666] (WB, Human)
• Allen JJ, Bell GR, Kuzirian AM, Hanlon RT. Cuttlefish skin papilla morphology suggests a muscular hydrostatic function for rapid changeability. J Morphol 2013-02-02 [PMID: 23378271] (IF/IHC, ICC/IF, Fish)
• Drucker KL, Paulsen AR, Giannini C et al. Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma Neuro Oncol 2013-01-10 [PMID: 23307575] (WB, Human)
• Salih DA, Rashid AJ, Colas D et al. FoxO6 regulates memory consolidation and synaptic function Genes Dev 2012-12-15 [PMID: 23222102] (WB, Mouse)
• Shih H J, Chen H H et al. Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity. Oncotarget 2012-01-11 [PMID: 23211466] (WB, Human)
• Berryer MH, Hamdan FF, Klitten LL et al. Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency Hum Mutat 2012-11-15 [PMID: 23161826] (WB, Human)
• Xie W, Parker JL, Heaps CL. Exercise Training-Enhanced, Endothelium-Dependent Dilation Mediated by Altered Regulation of BK(Ca) Channels in Collateral-Dependent Porcine Coronary Arterioles. Microcirculation 2013-02-01 [PMID: 23002811]
• Lin CW, Jan MS, Kuo JH et al. Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death. Eur J Pharm Sci. 2012-12-18 [PMID: 23000135] (WB, Human)
• Hanell A, Clausen F, Djupsjo A et al. Functional and Histological Outcome after Focal Traumatic Brain Injury Is Not Improved in Conditional EphA4 Knockout Mice J Neurotrauma 2012-11-01 [PMID: 22985250]
• Lee WC, Kan D, Chen YY et al. Suppression of Extensive Neurofilament Phosphorylation Rescues alpha-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death PLoS One 2012-01-01 [PMID: 22952800] (WB, Rat)
• Aro E, Khatri R, Gerard-O'Riley R et al. Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes J Biol Chem 2012-08-28 [PMID: 22930750] (WB, Mouse)
• Maj M, Milenkovic I, Bauer J et al. Novel insights into the distribution and functional aspects of the calcium binding protein secretagogin from studies on rat brain and primary neuronal cell culture Front Mol Neurosci 2012-01-01 [PMID: 22888312] (WB, Human, Rat)
• Minutolo A, Grelli S, Marino-Merlo F et al. D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent Cell Death Dis 2012-07-26 [PMID: 22833097] (WB, Human)
• Calnan DR, Webb AE, White JL et al. Methylation by Set9 modulates FoxO3 stability and transcriptional activity Aging 2012-07-01 [PMID: 22820736] (WB, Human)
• Wu H, Lu Y, Shen C et al. Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation Neuron 2012-07-12 [PMID: 22794264] (WB, Mouse)
• Wu MR, Hou MH, Lin YL, Kuo CF. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes.. J Agric Food Chem. 2012-07-25 [PMID: 22746947]
• Li T, Liu G, Li J, Wang X, Liu Q, Liu Z, Du W. Mechanisms of Prostate Permeability Triggered by Microbubble-Mediated Acoustic Cavitation Cell Biochem Biophys 2012-06-22 [PMID: 22722876] (WB, Rabbit)
• Wehenkel M, Ban JO, Ho YK et al. A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice Br J Cancer 2012-06-26 [PMID: 22677907] (WB, Human)
• Wu H, Lu Y, Barik A et al. Beta-Catenin gain of function in muscles impairs neuromuscular junction formation Development 2012-07-01 [PMID: 22627288] (WB, Mouse)
• Herroon MK, Rajagurubandara E, Rudy DL, Chalasani A, Hardaway AL, Podgorski I. Macrophage cathepsin K promotes prostate tumor progression in bone. Oncogene. 2012-05-21 [PMID: 22614014] (WB, Human)
• Stan T, Vijver D, Verhaart I, Aartsma-Rus A The vitamin B3analogue nicotinamide riboside has only very minor effects on reducing muscle damage inmdxmice bioRxiv 2023-02-03 (WB, Mouse)
• Dawson PA, Rakoczy J, Simmons DG. Placental, Renal, and Ileal Sulfate Transporter Gene Expression in Mouse Gestation Biol Reprod 2012-08-23 [PMID: 22674389] (WB, Mouse)
• Raimo Pohjanvirta, Hanna Miettinen, Satu Sankari, Nagabhooshan Hegde, Jere Linden. Unexpected gender difference in sensitivity to the acute toxicity of dioxin in mice, . Toxicology and Applied Pharmacology, 10.1016/j.taap.2012.04.032. 2012-01-01 [PMID: 22564538] (WB, Mouse)
• Yu M, Ge C, Zeng W et al. Retinoic acid promotes proliferation of chicken primordial germ cells via activation of PI3K/Akt-mediated NF-kappa B signalling cascade Cell Biol Int 2012-08-01 [PMID: 22548360] (WB, Chicken)
• Chang WW, Hu FW, Yu CC et al. Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer Head Neck 2013-03-01 [PMID: 22422628] (WB, Human)
• Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ, Hong CZ. Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury-possible involvements in hypoxia-inducible factor 1? (HIF-1?). J Comp Neurol doi: 10.1002/cne.23072. 2012-02-20 [PMID: 22351621]
• Carmony KC, Kim KB. PROTAC-induced proteolytic targeting. Methods Mol Biol 2012-01-01 [PMID: 22350917] (Human)
• Govaert KM, Nijkamp MW, Emmink BL, Steller EJ, Minchinton AI, Kranenburg O, Borel Rinkes IH. Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation. Br J Surgr;99(4):567-75. doi: 10.1002/bjs.8668. 2012-04-01 [PMID: 22331808]
• Zhang B, Liang C, Bates R et al. Wnt proteins regulate acetylcholine receptor clustering in muscle cells Mol Brain 2012-02-06 [PMID: 22309736] (WB, Mouse)
• Zhou Q, Xu G, Zhang X, Cao C, Zhou Z. Proteomics of post-traumatic proliferative vitreoretinopathy in rabbit retina reveals alterations to a variety of functional proteins. Curr Eye Res37(4):318-26. 2012-04-01 [PMID: 22295879] (WB, Rabbit)
• Swain U, Rao KS. Age-dependent decline of DNA base excision repair activity in rat cortical neurons. Mech Ageing Dev. 2012-04-01 [PMID: 22266244] (WB, Rat)
• Lee Wen-Ching, Chen Yun-Yu, Kan Daphne et al. A neuronal death model: overexpression of neuronal intermediate filament protein peripherin in PC12 cells. Journal of Biomedical Science 2012-01-01 [PMID: 22252275] (WB, Mouse)
• Edgel KA, McMillen TS, Wei H et al. Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice. Biochim Biophys Acta 2012-03-01 [PMID: 22179025] (WB, Mouse)
• Szabat M, Kalynyak TB, Lim GE et al. Musashi expression in [beta]-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes. Cell Death Dis 20112:e232. [PMID: 22113197]
• Tsai YY, Huang YH, Chao YL, Hu KY, Chin LT, Chou SH, Hour AL, Yao YD, Tu CS, Liang YJ, Tsai CY, Wu HY, Tan SW, Chen HM. Identification of the nanogold particle-induced endoplasmic reticulum stress by omic techniques and systems biology analysis. ACS Nano;5(12):9354-69. 2011-12-27 [PMID: 22107733] (WB, Human)
• Yang L-X, Yang Z-H, Guo R-W et al. Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice. J Renin Angiotensin Aldosterone Syst. 2011-10-21 [PMID: 22020146]
• Khan Z, Akhtar M, Ekstrom TJ. HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int J Mol Med 2011-12-01 [PMID: 21894430] (WB, Human)
• Chiang K-C, Yeh C-N, Chen H-Y et al. 19-Nor-2[alpha]-(3-hydroxypropyl)-1[alpha],25-dihydroxyvitamin D(3) (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells. Steroids. 2011-08-25 [PMID: 21888924]
• Gao L, Coope H, Grant S et al. ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. J Biol Chem 2011-10-21 [PMID: 21885437]
• van Houdt W J, Emmink B L et al. Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target. Mol Cell Proteomics 2011-01-12 [PMID: 21788403] (WB, Human)
• Rahardjo AK Effects of eukaryotic initiation factor 2A upregulation on protein synthesis in insulin producing cells Thesis 2022-01-01 (WB, Human, Mouse)
• Corcoran MP, Lichtenstein AH, Meydani M et al. The effect of 17{beta}-estradiol on cholesterol content in human macrophages is influenced by the lipoprotein milieu. J Mol Endocrinol. 2011-06-06 [PMID: 21646386] (WB, Human)
• Chia-Feng Kuo, Chih-Hsuan Hsieh, Wun-Yuan Lin. Proteomic response of LAP-activated RAW 264.7 macrophages to the anti-inflammatory property of fungal ergosterol.. Food chemistry. 2011-01-01
• Patschan O, Shariat SF, Chade DC et al. Association of tumor-associated trypsin inhibitor (TATI) expression with molecular markers, pathologic features and clinical outcomes of urothelial carcinoma of the urinary bladder World J Urol 2012-12-01 [PMID: 21739120] (IF/IHC, Human)
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  Details:
  Using the Purified form of this antibody.
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  Details:
  Citation using the Non-Recombinant Monoclonal format of this antibody.
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• Fogarty JA, Delp MD, Muller-Delp JM et al. Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs. J Vasc Res 2009-01-01 [PMID: 18769069] (WB)
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• Elsawa Sherine F, Novak Anne J, Grote Deanna et al. CDDO-imidazolide mediated inhibition of malignant cell growth in Waldenstrom macroglobulinemia. Leukemia Research 2008-01-01 [PMID: 18468679] (WB, Human)
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• Alejandro EU, Johnson JD. Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis. J Biol Chem 283(4):2407-17. 2008-01-25 [PMID: 18006502]
• Greer, EL et al. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 282(41):30107-19. 2007-10-12 [PMID: 17711846]
• Zhang, S et al. OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. Clin Cancer Res 13 (16):4750-8. 2007-08-15 [PMID: 17699852]
• Ougolkov, A et al. Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells. Blood 110(2):735-42. 2007-07-15 [PMID: 17463171]
• Park, K et al. Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci;27(11):2969-78. 2007-03-14 [PMID: 17360920]
• Dennis, Vida A et al. Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3. Infect Immun 74(10):5780-9. 2006-10-01 [PMID: 16988256]
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• Rice, PL et al Rice PL, Peters SL, Beard KS, Ahnen DJ. Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. Mol Cancer Ther 5(3):746-54. 2006-03-01 [PMID: 16546990]
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• Liu, X, Manser, T. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol 174(8):4505-15. 2005-04-15 [PMID: 15814671]
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• Sung, S et al. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am J Pathol;165(6):2197-206. 2004-12-01 [PMID: 15579461]
• Adler, S et al. Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase. Am J Physiol Renal Physiol;287(5):F907-13. 2004-11-01 [PMID: 15475543]
• Chong, V et al. Differential display polymerase chain reaction reveals increased expression of striatal rat glia-derived nexin following chronic clozapine treatment. Pharmacogenomics J 4(6):379-87. 2004-01-01 [PMID: 15354176]
• Mukherjee, P et al. Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Clin Cancer Res;10(16):5622-9. 2004-08-15 [PMID: 15328205]
• Laughlin, R et al. Involvement of raft-like plasma membrane domains of Entamoeba histolytica in pinocytosis and adhesion. Infect Immun 72(9):5349-57. 2004-09-01 [PMID: 15322032]
• Watters, JW et al. Genome-wide discovery of loci influencing chemotherapy cytotoxicity. PNAS 101:11809-11814. 2004-01-01 [PMID: 15282376]
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Reviews for beta-Actin Antibody (NB600-501) (29)

Average Rating: 4.8

(Based on 29 reviews)

We have 29 reviews tested in 4 species: Human, Mouse, Rat, Other.

reviewed by: Wei Yang Sit WB Human 05/29/2023

Summary

• Application: Western Blot
• Sample Tested: AGS human gastric adenocarcinoma cell line
• Species: Human
• Lot: 22190126

reviewed by: Verified Customer WB Mouse 02/14/2023

Summary

• Application: Western Blot
• Sample Tested: murine bone marrow derived macrophages
• Species: Mouse
• Lot: 22190126

reviewed by: Verified Customer ICC Mouse 01/22/2022

Summary

• Application: Immunocytochemistry
• Sample Tested: fibroblasts
• Species: Mouse
• Lot: AC-15

reviewed by: Verified Customer WB Human 05/16/2021

Summary

• Application: Western Blot
• Sample Tested: HEK293
• Species: Human
• Lot: 90942

reviewed by: John Morgan WB Human 01/31/2019

Summary

• Application: Western Blot
• Sample Tested: HepG2 CELLS
• Species: Human
• Lot: 106M4825V-4

reviewed by: Anthony Morales WB Rat 01/28/2019

Summary

• Application: Western Blot
• Sample Tested: Mouse brain
• Species: Rat
• Lot: 014M4759

reviewed by: Verified Customer WB Human 01/24/2019

Summary

• Application: Western Blot
• Sample Tested: mouse hepatocytes and HepG2 cells
• Species: Human
• Lot: 105M4825V-3

reviewed by: Luiz Alexandre Magno WB Mouse 07/17/2018

Summary

• Application: Western Blot
• Sample Tested: Brain (corpus striatum),Mouse brain
• Species: Mouse
• Lot: 014M4759

Comments

• Comments: I have used this antibody for several years and it has worked perfectly in our western blots. It works very well at 1:10,00 dilution when loading gels with 30 ug of protein extracts. I congratulate Novus Biologicals for this achievement.

reviewed by: Verified Customer WB Human 02/20/2018

Summary

• Application: Western Blot
• Sample Tested: 293T lysate
• Species: Human
• Lot: 105M4825V-3

reviewed by: Liyong Zhang WB Human 11/25/2017

Summary

• Application: Western Blot
• Sample Tested: mouse hepatocytes and HepG2 cells
• Species: Human
• Lot: 105M4825V-3

reviewed by: Verified Customer WB Human 06/05/2015

Summary

• Application: Western Blot
• Sample Tested: human glioma cells
• Species: Human

reviewed by: Verified Customer WB Human 05/29/2015

Summary

• Application: Western Blot
• Sample Tested: Fibroblast Hs68 cell lysate
• Species: Human

reviewed by: Verified Customer WB Human 03/25/2015

Summary

• Application: Western Blot
• Sample Tested: Caco-2, T84, HCT116, HT29, DU145, BPH1, Hela
• Species: Human

reviewed by: Verified Customer WB Other 02/20/2015

Summary

• Application: Western Blot
• Sample Tested: Whole Skeletal Muscle Lysate
• Species: Other

reviewed by: Sandra Vieira WB Human 01/23/2015

Summary

• Application: Western Blot
• Sample Tested: Whole cell lysates: CHO, GC-1, Hela, Cos-7, SH-SY5Y
• Species: Human
• Lot: 083M4851

reviewed by: Liyong Zhang WB Mouse 07/01/2014

Summary

• Application: Western Blot
• Species: Mouse

reviewed by: Beatrice Gini WB Human 12/02/2013

Summary

• Application: Western Blot
• Sample Tested: human brain cells
• Species: Human

reviewed by: Verified Customer WB Human 12/21/2011

Summary

• Application: Western Blot
• Sample Tested: Human cancer cell line
• Species: Human

reviewed by: Verified Customer WB Mouse 12/21/2011

Summary

• Application: Western Blot
• Sample Tested: Mouse BALB/c macrophage cell line
• Species: Mouse

reviewed by: Verified Customer WB Mouse 12/14/2011

Summary

• Application: Western Blot
• Sample Tested: Mouse
• Species: Mouse

reviewed by: Verified Customer WB Human 12/08/2011

Summary

• Application: Western Blot
• Sample Tested: Human
• Species: Human

reviewed by: Verified Customer WB Rat 12/06/2011

Summary

• Application: Western Blot
• Sample Tested: Rat
• Species: Rat

reviewed by: Verified Customer WB Human 12/05/2011

Summary

• Application: Western Blot
• Sample Tested: Human
• Species: Human

reviewed by: Verified Customer WB Mouse 11/30/2011

Summary

• Application: Western Blot
• Sample Tested: mouse brain
• Species: Mouse

reviewed by: Verified Customer WB Human 11/21/2011

Summary

• Application: Western Blot
• Sample Tested: Human Cell lines
• Species: Human

reviewed by: Verified Customer WB Other 11/09/2011

Summary

• Application: Western Blot
• Sample Tested: Chicken cell lines
• Species: Other

reviewed by: Wei-I Shiao WB Mouse 09/02/2011

Summary

• Application: Western Blot
• Sample Tested: Mouse Cells
• Species: Mouse

reviewed by: Courtney Kurtz WB Other 08/11/2011

Summary

• Application: Western Blot
• Sample Tested: Ground squirrel small intestinal lysate, Sample Amount: 50 ug
• Species: Other

reviewed by: Verified Customer WB Mouse 08/30/2010

Summary

• Application: Western Blot
• Sample Tested: 293T whole cell lysate, adult neural stem cell whole cell lysate
• Species: Mouse

FAQs for beta-Actin Antibody (NB600-501). (Showing 1 - 10 of 12 FAQs).

1. Why is beta actin used as a loading control in blotting ?
   • Beta actin is a highly-expressed protein found in all cells, and is considered a house keeping protein whose expression is necessary for any cell's proper functioning. For this reason it is used as a loading control to confirm that the same amount of total protein is loaded in each lane of an SDS-PAGE gel so that appropriate comparisons can be made between the actual proteins of interest in different samples.
2. Are the beta-Actin antibodies validated in Simple Western?
   • Yes, we offer a few beta actin antibodies that have been tested in Simple Western: NBP1-47423, NB600-501, NB600-532, NB600-503, and NB100-56874.
3. Do Beta-Actin antibodies come in lyophilized format?
   • ACTB antibodies like MAB8969 AND MAB8929 come in lyophilized form.
4. What is the theoretical molecular weight for Beta-Actin antibodies?
   • The TMW for beta Actin antibodies is approximately 42 kDa.
5. I wanted to know which of the two housekeeping genes B-actin or GAPDH can be used for best results. I intend to do an experiment to determine expression of IL-6 and TNF-alpha in liver and kidney tissues.
   • For homogenized tissue, beta-actin and GAPDH are both fine.
6. We have these Abs: NB120-19481 PPAR gamma Antibody and NB600-501 Beta Actin Antibody (AC-15). The samples that we are analyzing are bovine ones. Please, confirm me if those proteins are valid like positive controls in WB for those antibodies: 1. Beta Actin Recombinant Protein (H00000060-P01). 2. PPAR gamma Protein (NBP1-45290) 3. PPAR gamma Protein (H00005468-P01) 4. PPAR gamma Protein (H00005468-Q01). Or perhaps could be better those lysates: 1. Beta Actin Lysate - L015T6 2. Beta Actin Lysate - H00000060-T02 3. PPAR gamma Lysate - NBL1-14634 4. PPAR gamma Lysate - NBL1-14633 5. PPAR gamma Lysate - NBL1-14635.
   • I recommend the below controls as we have validated these as controls. NB120-19481: 2. PPAR gamma Protein (NBP1-45290) 3. PPAR gamma Protein (H00005468-P01) 4. PPAR gamma Protein (H00005468-Q01). NB600-501: 1. Beta Actin Lysate - L015T6 2. Beta Actin Lysate - H00000060-T02
7. I would like to try the Beta Actin Antibody (AC-15) you have in stock to see if it reacts with fish samples in a Western Blot. Also, I would like to know if you have more information about its reactivity with fish?
   • We have tested that this antibody NB600-501 is reactive with fish. It has been tested with use in black carp. The homology with black carp is 99.0%.
8. Could anti-beta actin antibody recognize the actin derived from mosquito cells (C6/36)?
   • Unfortunately we have not used our antibody with catalogue number NB600-501 to detect beta actin that is derived from mosquito cells. You may however wish to align the peptide immunogen sequence against the full length mosquito beta actin sequence to check the homology. We usually suggest that a homology of greater than 80% is indicative of likely binding. The immunogen sequence for NB600-501 is Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys (DDDIAALVIDNGSGK).
9. May we ask if NB600-501 has been tested with samples from zebrafish?
   • Beta Actin is a highly conserved protein and yes, our Beta Actin antibody (clone AC-15) NB600-501 is guaranteed for Zebrafish species.
10. What is the immunogen sequence of this Beta-Actin antibody?
    • A sequence (Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys) within the N-terminal region of beta Actin, conjugated to KLH.
11. Could you please tell me the concentration of beta-Actin Antibody (AC-15) (Nb600-501SS), LOT#077M4757V.
    • This antibody is unpurified (provided as ascites fluid) and hence the antibody concentration is non-quantifiable.
12. I noticed that two of your beta-actin antibodies share the same immunogen and clone number. Could you help me determine the difference between the two: NB600-501 and NB110-67828? 
    • I can confirm that the two antibodies are the same clone, meaning the antibody itself is the same for both products. The principle difference between the two products is the format: NB600-501 is unpurified ascite whereas NB110-67828 is purified.  
Show All 12 FAQs.

Bioinformatics

• Gene Symbol: ACTB