Bone marrow stromal cell antigen 1/CD157 Antibody

Immunohistochemistry-Paraffin: Bone marrow stromal cell antigen 1/CD157 Antibody [NBP2-24581] - Analysis of BST1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control antibody(top) and BST1 antibody (bottom) at 5 ug/ml.

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Bone marrow stromal cell antigen 1/CD157 Antibody Summary

• Immunogen: A portion of amino acids 30-80 of human BST1 was used as the immunogen for this antibody.
• Predicted Species: Mouse (100%), Rat (93%), Chicken (100%), Equine (100%), Chimpanzee (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BST1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 100% homologous in human isoforms CRA_a, CRA_b, CRA_e and CRA_f (ranging between 440 and 589 amino acids), monkey, chicken, horse, mouse and chimpanzee, 93% homologous in rat, 87% homologous in zebrafish and xenopus and 81% homologous in pufferfish.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Bone marrow stromal cell antigen 1/CD157 Antibody

• ADP-ribosyl cyclase 2
• Bone marrow stromal antigen 1
• bone marrow stromal cell antigen 1
• BP-3
• BST1
• BST-1
• cADPr hydrolase 2
• CD157 antigen
• CD157
• Cyclic ADP-ribose hydrolase 2
• EC 3.2.2.5
• NAD(+) nucleosidase

Background

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Bone marrow stromal cell antigen 1/CD157 Antibody (NBP2-24581). (Showing 1 - 2 of 2 FAQ).

1. I am wondering why bone marrow stromal cell antigen 1(BST1) express in human brain, because, as far as I know, there is no report which shows BST1 express in human (or in mouse) brain.
   • The mRNA for CD157 (BST1) is expressed in human cerebral cortex, even though it is low. Similarly, out of 4 brain (tumor/cancer) cell lines examined, two express low mRNA. Finally, glioma tissues express the low levels of the protein.
2. Can NBP2-24581 be used for a frozen (for example O.C.T compound embedded) section?
   • Usually if an antibody can work for IHC-P, frequently it can also be used in IHC-Fr (frozen section)

Bioinformatics

• Gene Symbol: BST1
• Uniprot:
  • Q10588(Human)