C1q Native Protein

Product Discontinued

C1q Native Protein Summary

• Description: Native human C1q.
  
  

  Source:Human serum

  Amino Acid Sequence:UniProt P02747, P02745, P02746

• Source: Human serum
• Protein/Peptide Type: Native Protein
• Gene: C1QA
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • ELISA
• Theoretical MW: 410 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 0.01 M Na2EDTA, 0.3 M NaCl, pH 7.5
• Concentration: LYOPH
• Purity: >95%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute with 1.0 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix vial after reconstitution. The solution may appear cloudy following reconstitution.

Alternate Names for C1q Native Protein

• A chain
• complement component 1, q subcomponent, A chain
• complement component 1, q subcomponent, alpha polypeptide

Background

C1q encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for C1q Native Protein (NBP2-62410)(3)

Publications using NBP2-62410

• Cong T, Sun Y, Zhou Y et al. Blocking Two-Pore Domain Potassium Channel TREK-1 Inhibits the Activation of A1-Like Reactive Astrocyte Through the NF-?B Signaling Pathway in a Rat Model of Major Depressive Disorder Neurochemical research 2023-01-20 [PMID: 36670238]
• Fei X, Dou YN, Wang L et al. Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage Journal of neuroinflammation 2022-03-14 [PMID: 35287697]
• Li L, Li Y, He B et al. HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats Journal of neuroinflammation 2021-09-16 [PMID: 34530848]

FAQs for C1q Native Protein (NBP2-62410). (Showing 1 - 1 of 1 FAQs).

1. I am looking for polyclonal/monoclonal antibodies against canine C1q and complement-related. I was wondering if your prooduct does.
   • Please see the provided link below which will take you to our website and all of our C1Q antibodies that are available. Unfortunately we do not currently have an antibody that has been tested in dog but if that would be something you are interested in doing, I would like to invite you to review our Innovator's rewards program. Should you have any questions or concerns, please do not hesitate to contact me directly. C1Q antibodies: Innovators Rewards Program

Bioinformatics

• Gene Symbol: C1QA