Desmin Antibody (D33)

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - Formalin fixed paraffin embedded human leiomyoma stained with Desmin antibody (NB120-17156).

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - Paraffin embedded human leiomyoma stained with Desmin antibody.

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - FFPE human leiomyoma.

Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - Rat heart tissue, alcohol fixed, paraffin embedded. Image from verified customer review.

• Reactivity: Hu
• Applications: IHC
• Clone: D33
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Desmin Antibody (D33) Summary

• Immunogen: BALB/C mice were immunized with purified desmin from human muscle.
• Localization: Cytoplasmic
• Specificity: This antibody reacts with desmin protein of 53 kDa. Both striated as well as smooth muscle cells stain well with this antibody. The antibody shows a broad interspecific cross-reactivity, reacting with human.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: DES
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
• Application Notes: IHC-P: recommended incubation time of 30 min at RT.
• Control:

  Desmin Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: Tissue culture supernatant
• Preservative: 0.05% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for Desmin Antibody (D33)

• CMD1I
• CMD1IFLJ41013
• CSM1
• CSM2
• DES
• Desmin
• FLJ12025
• FLJ39719
• FLJ41793
• intermediate filament protein

Background

Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Desmin Antibody (NB120-17156)(1)

Publication using NB120-17156

• Hayashi T, Konishi I Familial Gastrointestinal Stromal Tumor Associated with Zebra-like Pigmentation Biomedicines 2023-05-30 [PMID: 37371685] (IHC-P, Human)

Review for Desmin Antibody (NB120-17156) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Rat.

reviewed by: Verified Customer IHC-P Rat 01/07/2019

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: Heart tissue
• Species: Rat
• Lot: H494NB

Comments

• Comments: Rat heart tissue - Alcohol-fixed paraffin embedded

Bioinformatics

• Gene Symbol: DES
• Entrez:
  • 1674(Human)
  • 64362(Rat)