| Immunogen | Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with dopamine conjugated with bovine serum albumin. |
| Specificity | This detects catecholamine. Affinity of Mab 2BG11: Kd = 10^-8 for DA-BSA Kd = 10^-7 for NA-BSA Kd = 10^-4 for unconjugated DA. At 1 uM MAb 2B11 inhibits dopamine binding to D-2 receptor in membrane P-2 fraction from human Corpus striatum. |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Host | Mouse |
| Purity | Protein G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
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| Storage | Store at 4C. Do not freeze. |
| Buffer | PBS (pH 7.4) |
| Preservative | 0.09% Sodium Azide |
| Purity | Protein G purified |
| Publication using NB110-2538 | Applications | Species |
|---|---|---|
| Lee JS, Lee SB, Kim DW Et al. Social isolation-related depression accelerates ethanol intake via microglia-derived neuroinflammation Science advances 2021-11-05 [PMID: 34739315] (IHC-Fr, Mouse) | IHC-Fr | Mouse |
Secondary Antibodies |
Isotype Controls |
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How DOPA Decarboxylase Affects Neurotransmitter Synthesis DOPA decarboxylase (DDC) is responsible for catalyzing the conversion of aromatic amino acids into their corresponding amines during the synthesis of several important neurotransmitters. Specifically, DDC catalyzes the decarboxylation of L-DOPA to ... Read full blog post. |
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Tyrosine hydroxylase - a marker for dopaminergic neurons in the central nervous system Tyrosine hydroxylase is a member of the aromatic amino acid hydroxylase (AAAH) family. It is expressed throughout the central nervous system (CNS) and catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which can be, thr... Read full blog post. |
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