Fibrillin 1 Antibody (11C1.3) [Biotin]

Product Discontinued

Fibrillin 1 Antibody (11C1.3) [Biotin] Summary

• Immunogen: Microfibrils from zonular apparatus of bovine eye
• Specificity: Human and bovine fibrillin (Mr 350 kDa)
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: FBN1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Immunomicroscopy
  • Western Blot 1 ug/ml
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Reactivity Notes

Bovine and Human.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Fibrillin 1 Antibody (11C1.3) [Biotin]

• ACMICD
• Asprosin
• FBN
• FBN1
• fibrillin 1 (Marfan syndrome)
• Fibrillin 1
• fibrillin 15
• fibrillin-1
• GPHYSD2
• MASS
• MFS1
• OCTD
• SGS
• SSKS
• WMS
• WMS2

Background

Fibrillin is the major constitutive element of extracellular microfibrils and has widespread distribution in both elastic and nonelastic connective tissue throughout the body. The cDNA was identified in 1991 and was mapped coincident with the locus for Marfan syndrome. Subsequent studies confirmed that mutations in the Fibrillin 1 gene are the major cause of Marfan syndrome. The connective tissue protein has a widespread distribution in the connective tissue matrices of skin, lung, kidney, vasculature, cartilage, tendon, muscle, cornea, and ciliary zonule. Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended threadlike shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor like (EGF like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8 cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule. Fibrillin 1 contains a proline rich region close to the N terminus that is replaced by a glycine rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Fibrillin 1 Antibody (NBP1-26563). (Showing 1 - 1 of 1 FAQ).

1. Hi - I have been looking at the fibrillin1 antibodies on your website. You indicate that some may be suitable for canine tissue on your website. could you let me know which of the 10 antibodies is the most suitable for canine.
   • We have unfortuantely not tested any of our products in canine samples. If you would like to try one of our product with canine samples, you would qualify for our Innovator's Reward Program. In exchange for a review of our product in an untested application or species, we would issue you a credit voucher for the purchase price. If you would like us to check the homology of a certain product against the canine sequence, just contact our technical support department at technical@novusbio.com.

Bioinformatics

• Gene Symbol: FBN1