GAT3 Antibody

Product Discontinued

GAT3 Antibody Summary

• Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-3.
• Specificity: Specific for the ~67k GAT-3 protein. Immunolabeling is blocked by the peptide used as antigen.
• Predicted Species: Mouse (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC6A11
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:200
  • Western Blot 1:1000
• Theoretical MW: 67 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: 10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for GAT3 Antibody

• GABA Transporter 3
• GABT3
• GAT-3
• GAT3sodium- and chloride-dependent GABA transporter 3
• GAT4
• solute carrier family 6 (neurotransmitter transporter, GABA), member 11
• Solute carrier family 6 member 11

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GAT3 Antibody (NBP2-29375)(1)

Publication using NBP2-29375

• Pallottie A, Ratnayake A, Ni L et al. A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. Sci Rep 2018-06-07 [PMID: 29880832] (WB, Mouse)

Bioinformatics

• Gene Symbol: SLC6A11