Hairless Antibody

Immunocytochemistry/Immunofluorescence: Hairless Antibody [NBP2-58404] - Staining of human cell line PC-3 shows localization to nucleoplasm.

Product Discontinued

Hairless Antibody Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: THWRCPRCSHRLCVACGRVAGTGRAREKAGFQEQSAEECTQEAGHAACSLMLTQFVSSQALAELSTAMHQVWVKFDIRGHCPCQADARVWAPGDAGQQKESTQKTPPTPQPSCNGDTHRTKSIKEETPDSAETP
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HR
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
• Application Notes: Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Reactivity Notes

Mouse 81%

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Hairless Antibody

• ALUNC
• AU
• AUHSA277165
• FLJ98880
• hairless (mouse) homolog
• hairless homolog (mouse)
• Hairless
• HR
• MUHH
• MUHH1
• protein hairless

Background

HR (hairless) is 1189 amino acids long, weighing approximately 127 kDa, with a short isomer that is 1134 amino acids long, weighing approximately 122 kDa. HR functions as a transcription factor that regulates the phases of hair growth, with strong expressions in the small intestine and the skin (for isoform 2 only), and weak expressions in the brain and colon. Current studies are being done on several diseases and disorders including atrichia with popular lesions, hypotrichosis, thyroiditis, and autosomal recessive diseases. HR has also been shown to have interactions with VDR, ESR2, RARA, TBL1X, and HDAC1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HR