HLA-DR Antibody (L203)

• Reactivity: Hu
• Applications: Flow, CyTOF-ready
• Clone: L203
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

HLA-DR Antibody (L203) Summary

• Immunogen: RPMI 8866 human lymphoblastoid cells
  Accession # P01903
• Specificity: Detects human HLA‑DR.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: HLA-DRA
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HLA-DR Antibody (L203)

• FLJ51114
• histocompatibility antigen HLA-DR alpha
• HLA class II histocompatibility antigen, DR alpha chain
• HLADR
• HLA-DR
• HLA-DRA
• HLA-DRA1
• major histocompatibility complex, class II, DR alpha
• MHC cell surface glycoprotein
• MHC class II antigen DRA
• MHC Class II DR
• MLRW

Background

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4⁺ T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HLA-DR Antibody (MAB4869)(4)

Publications using MAB4869

• J Li, SQ Xu, YM Zhao, S Yu, LH Ge, BH Xu Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord Mol Med Rep, 2018-09-20;0(0):. 2018-09-20 [PMID: 30272340] (Flow Cytometry, Human)
• Chypre M, Seaman J, Cordeiro O, Willen L, Knoop K, Buchanan A, Sainson R, Williams I, Yagita H, Schneider P, Mueller C Characterization and application of two RANK-specific antibodies with different biological activities. Immunol Lett, 2016-01-07;171(0):5-14. 2016-01-07 [PMID: 26773232] (Flow Cytometry, Human)
• Loubaki L, Chabot D, Bazin R Involvement of the TNF-alpha/TGF-beta/IDO axis in IVIg-induced immune tolerance. Cytokine, 2014-11-19;71(2):181-7. 2014-11-19 [PMID: 25461397] (Flow Cytometry, Human)
• Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4. 2008-12-03 [PMID: 19056110] (Neutralization, Human)

Bioinformatics

• Gene Symbol: HLA-DRA
• Uniprot:
  • P01903()