Human Cerebral Cortical Neurons (Young hCCNs Frozen)

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Human Cerebral Cortical Neurons (Young hCCNs Frozen) Summary

• Description: Advantages of hCCNs: 1. Human cells;
  2. High purity neural progenitor population;
  3. Ready-made, easy to maintain and differentiate;
  4. Robust enough to undergo genetic manipulation;
  5. Functional and molecular features extensively characterized;
  6. Capable of differentiating into an array of cortical neurons and astrocytes;
  7. Remain viable in culture for months to facilitate reproducible and long term studies;
  8. Available in industrial quantity;
  9. Cells from multiple donors (>6) are available for purchase allowing data comparison among biological replicates.
  
  
  This product is powered by Axol Bioscience Ltd.
• Background: This product is provided with the following additional items free of charge: Sure Boost ( TM ) Supplement: NBP2-31355 and Neural Enhance ( TM ) Supplement: NBP2-31356
  
  Human cerebral cortical neurons are derived from NIH approved induced pluripotent stem cell (iPSC) lines under a fully defined neural induction condition (Shi, Y. et al, 2012a, b, c). The hCCNs & hyCCNs express typi...cal markers of cerebral cortical neurons such as Tbr1, Ctip2, Brn2 and Cux1. The cortical neurons are electrically active and have the ability to form functional synapses and circuits in vitro. In addition, the cortical neurons transplanted into the neonatal rat cortices can project long distances to innervate other regions of cerebral cortex. Cerebral cortical neurons have been implicated in numerous neurological diseases including Alzheimer's disease, autism, epilepsy and stroke. Despite strong interest in these diseases, high quality human in vitro cell models for cortical neurophysiology were not available until now. With hCCNs and hyCCNs, we provide neuroscience researchers with a high quality in vitrohuman system to complement their existing studies of cortical development, function and disorders in animal models.
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• Specificity: 1. Cell Type: Neural progenitors
  2. Species: Human
  3. Source: Human iPSCs (reprogrammed with episomal vectors; no gene insertion detected in the iPSCs)
  4. Donor gender: Female
  5. Donor age: Newborn
  6. Karyotype: Normal
  7. Quantity: 2 x 10^6 viable cells
  8. Presentation: Cells are provided cryopreserved in 1 ml of freezing medium
  9. Growth Properties: Adherent
  10. Quality Assurance: Cells are negative for HIV, HBV, HCV, bacteria, mycoplasma and fungal contamination

Applications/Dilutions

• Application Notes: Applications Including but not limited to:
  1. Studying Corticogenesis in vitro
  2. Studying neural network formation and signal transmission
  3. Disease modelling
  4. Neurotoxicity testing
  5. Preclinical drug efficacy testing
  6. Research and development of cell therapies in animal models

Packaging, Storage & Formulations

• Storage: Store in gas phase of liquid nitrogen.

Alternate Names for Human Cerebral Cortical Neurons (Young hCCNs Frozen)

• Cerebral Cortical Neurons ( hCCNs Frozen)
• Cerebral Cortical Neurons
• Human Cerebral Cortical Neurons

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.