Human Galectin-3 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Galectin-3 Quantikine ELISA Kit Summary

• Background: The Quantikine Human Galectin-3 Immunoassay is a 4.5 hour solid phase ELISA designed to measure Galectin-3 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human Galectin-3 and antibodies raised against the recombinant protein. Results obtained for naturally occurring human Galectin-3 showed linear curves that were parallel to the stand...ard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural human Galectin-3.
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• Specificity: Natural and recombinant human Galectin-3. This assay cross-reacts 58% with Mouse Galectin-3.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: LGALS3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Galectin-3 Quantikine ELISA Kit

• AGE-R3
• Carbohydrate-binding protein 35
• CBP 35,35 kDa lectin
• CBP35
• GAL3
• Gal-3
• galactin-3
• Galactose-specific lectin 3
• Galactoside-binding protein
• GALBPCBP35
• Galectin3
• Galectin-3
• GALIG
• IgE-binding protein
• L29
• L31
• L-31
• Laminin-binding protein
• Lectin L-29
• lectin, galactoside-binding, soluble, 3
• LGALS2
• LGALS3
• Mac-2 antigen
• Mac-2
• MAC2GAL3

Background

The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Galectin-3 (DGAL30)(39)

Publications using DGAL30

• Kosmider, O;Possémé, C;Templé, M;Corneau, A;Carbone, F;Duroyon, E;Breillat, P;Chirayath, TW;Oules, B;Sohier, P;Luka, M;Gobeaux, C;Lazaro, E;Outh, R;Le Guenno, G;Lifermann, F;Berleur, M;Le Mene, M;Friedrich, C;Lenormand, C;Weitten, T;Guillotin, V;Burroni, B;Boussier, J;Willems, L;Aractingi, S;Dionet, L;Tharaux, PL;Vergier, B;Raynaud, P;Ea, HK;Ménager, M;Duffy, D;Terrier, B; VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation Nature communications 2024-01-30 [PMID: 38291039] (Human)
• Haertel, F;Lustermann, P;Hamadanchi, A;Gruen, K;Bogoviku, J;Aftanski, P;Westphal, J;Baez, L;Franz, M;Schulze, PC;Moebius-Winkler, S; Prognostic Value of Galectin-3 after Left Atrial Appendage Occlusion for Predicting Peri-Device Leakage International journal of molecular sciences 2023-11-27 [PMID: 38069127] (Human)
• Nikitopoulou, I;Vassiliou, AG;Athanasiou, N;Jahaj, E;Akinosoglou, K;Dimopoulou, I;Orfanos, SE;Dimakopoulou, V;Schinas, G;Tzouvelekis, A;Aidinis, V;Kotanidou, A; Increased Levels of Galectin-3 in Critical COVID-19 International journal of molecular sciences 2023-10-31 [PMID: 37958814] (Human)
• Pommier, T;Lafont, A;Didier, R;Garnier, L;Duloquin, G;Meloux, A;Sagnard, A;Graber, M;Dogon, G;Laurent, G;Vergely, C;Béjot, Y;Guenancia, C; Factors associated with patent foramen ovale-related stroke: SAFAS study Revue neurologique 2023-09-28 [PMID: 37777437] (Human)
• Bhutada, S;Tran-Lundmark, K;Kramer, B;Conner, P;Lowry, AM;Blackstone, E;Frenckner, B;Mesas-Burgos, C;Apte, SS; Identification of protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid Scientific reports 2023-09-19 [PMID: 37726509] (Human)
• Puccini, M;Jakobs, K;Reinshagen, L;Friebel, J;Schencke, PA;Ghanbari, E;Landmesser, U;Haghikia, A;Kr�nkel, N;Rauch, U; Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19 International journal of molecular sciences 2023-04-22 [PMID: 37175392] (Human)
• P Branco, R Calça, AR Martins, C Mateus, MJ Jervis, DP Gomes, S Azeredo-Lo, AF De Melo Ju, C Sousa, E Civantos, S Mas-Fontao, A Gaspar, S Ramos, J Morello, F Nolasco, A Rodrigues, SA Pereira Fibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysis International Journal of Molecular Sciences, 2023-03-06;24(5):. 2023-03-06 [PMID: 36902451] (Human)
• JO Chung, SY Park, SB Lee, NR Kang, DH Cho, DJ Chung, MY Chung Plasma galectin-3 concentration and estimated glomerular filtration rate in patients with type 2 diabetes with and without albuminuria Scientific Reports, 2022-09-29;12(1):16328. 2022-09-29 [PMID: 36175599] (Human)
• F Shiraseb, M Farazi, N Rasaei, CCT Clark, S Jamili, K Mirzaei The interaction between rs 3,807,992 genotypes with the dietary inflammatory index on Leptin, Leptin resistance, and Galectin 3 in obese and overweight women BMC endocrine disorders, 2022-09-23;22(1):237. 2022-09-23 [PMID: 36151575] (Human)
• J Milosevic, M Jurisevic, V Grbovic, I Jovanovic, N Gajovic, A Jurisic-Sk Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study International Journal of Environmental Research and Public Health, 2022-09-13;19(18):. 2022-09-13 [PMID: 36141752] (Human)
• P Simeone, R Tripaldi, A Michelsen, T Ueland, R Liani, S Ciotti, KI Birkeland, HL Gulseth, A Di Casteln, F Cipollone, P Aukrust, A Consoli, B Halvorsen, F Santilli Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss Cardiovascular Diabetology, 2022-03-11;21(1):36. 2022-03-11 [PMID: 35277168] (Human)
• A Rühle, AL Grosu, N Wiedenmann, J Ruf, B Bieber, R Stoian, AR Thomsen, E Gkika, P Vaupel, D Baltas, WA Weber, M Mix, NH Nicolay The value of plasma hypoxia markers for predicting imaging-based hypoxia in patients with head-and-neck cancers undergoing definitive chemoradiation Clinical and translational radiation oncology, 2022-02-21;33(0):120-127. 2022-02-21 [PMID: 35243023] (Human)
• KN Lee, DY Kim, KY Boo, YG Kim, SY Roh, YS Baek, DH Kim, DI Lee, J Shim, JI Choi, GS Hwang, YH Kim Therapeutic implications of galectin-3 in patients with atrial fibrillation Scientific Reports, 2022-01-17;12(1):784. 2022-01-17 [PMID: 35039576] (Human)
• S Liu, Q Wu, S Zhang, Z Wang, H Liu, L Teng, P Xiao, Y Lu, X Wang, C Dong, J Xiao, J Zhang Serum Galectin-3 levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: a prospective cohort study Bmc Nephrology, 2022-01-03;23(1):5. 2022-01-03 [PMID: 34979958] (Human)
• B Ku?nierz-C, B Maziarz, P Dumnicka, M Dembi?ski, M Kapusta, M Boci?ga-Ja, M Winiarski, A Garlicki, T Grodzicki, M Kukla Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19-A Preliminary Study Oncogene, 2021-08-01;11(8):. 2021-08-01 [PMID: 34439802] (Human)
• P Wa?ek, U Grabowska, E Cie?la, J Sielski, J Roskal-Wa?, B Wo?akowska Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation Biomolecules, 2021-07-28;11(8):. 2021-07-28 [PMID: 34439775] (Human)
• H Kanemasa, M Ishimura, K Eguchi, T Tanaka, E Nanishi, A Shiraishi, M Goto, Y Motomura, S Ohga The immunoregulatory function of peripheral blood CD71+ erythroid cells in systemic-onset juvenile idiopathic arthritis Scientific Reports, 2021-07-13;11(1):14396. 2021-07-13 [PMID: 34257378] (Human)
• Y Hammer, Y Talmor-Bar, A Abelow, K Orvin, Y Aviv, N Bar, A Levi, U Landes, G Shafir, A Barsheshet, H Vaknin-Ass, A Sagie, R Kornowski, A Hamdan Myocardial extracellular volume quantification by computed tomography predicts outcomes in patients with severe aortic stenosis PLoS ONE, 2021-03-10;16(3):e0248306. 2021-03-10 [PMID: 33690718] (Human)
• M Žarak, A Perovi?, M Njire Brat, S Šupraha Go, J Dumi? Adaptive response triggered by the repeated SCUBA diving is reflected in cardiovascular, muscular, and immune biomarkers Physiological Reports, 2021-01-01;9(2):e14691. 2021-01-01 [PMID: 33463896] (Human)
• M d'Alessand, E De Vita, L Bergantini, MA Mazzei, S di Valvaso, M Bonizzoli, A Peris, P Sestini, E Bargagli, D Bennett Galactin-1, 3 and 9: Potential biomarkers in idiopathic pulmonary fibrosis and other interstitial lung diseases Respir Physiol Neurobiol, 2020-09-11;282(0):103546. 2020-09-11 [PMID: 32920057] (Human)
• BD Snarr, G St-Pierre, B Ralph, M Lehoux, Y Sato, A Rancourt, T Takazono, SR Baistrocch, R Corsini, MP Cheng, M Sugrue, LR Baden, K Izumikawa, H Mukae, JR Wingard, IL King, M Divangahi, MS Satoh, BG Yipp, S Sato, DC Sheppard Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus�infection PLoS Pathog., 2020-08-04;16(8):e1008741. 2020-08-04 [PMID: 32750085] (Human)
• E Kowalik, A Kwiatek-Wr, A Klisiewicz, A Lutynska, EK Biernacka, M Kowalski, P Hoffman Systemic right ventricle in elderly patients with congenitally corrected transposition of the great arteries: Clinical profile, cardiac biomarkers, and echocardiographic parameters Anatol J Cardiol, 2020-08-01;24(2):92-96. 2020-08-01 [PMID: 32749250] (Human)
• P ?wi?cki, R Sawicki, M Knapp, KA Kami?ski, K Ptaszy?ska, B Sobkowicz, A Lisowska Galectin-3 as the Prognostic Factor of Adverse Cardiovascular Events in Long-Term Follow up in Patients after Myocardial Infarction-A Pilot Study J Clin Med, 2020-05-29;9(6):. 2020-05-29 [PMID: 32485853] (Human)
• Y Fujii Evaluation of Inflammation Caused by Cardiopulmonary Bypass in a Small Animal Model Biology (Basel), 2020-04-20;9(4):. 2020-04-20 [PMID: 32326072] (Rat)
• YH Jung, D Han, SH Shin, EK Kim, HS Kim Proteomic identification of early urinary-biomarkers of acute kidney injury in preterm infants Sci Rep, 2020-03-04;10(1):4057. 2020-03-04 [PMID: 32132597] (Human)
• FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019-06-21;4(10):1373-1386. 2019-06-21 [PMID: 31701047] (Human)
• H Yogasundar, A Nikhanj, BN Putko, M Boutin, S Jain-Ghai, A Khan, C Auray-Blai, ML West, GY Oudit Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction J Am Heart Assoc, 2018-11-06;7(21):e009098. 2018-11-06 [PMID: 30571380] (Human)
• CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients J Clin Med, 2018-11-08;7(11):. 2018-11-08 [PMID: 30413105] (Human)
• SM Seo, SH Kim, Y Kim, HE Yoon, SJ Shin Prognostic Utility of Soluble Suppression of Tumorigenicity 2 level as a Predictor of Clinical Outcomes in Incident Hemodialysis Patients Int J Med Sci, 2018-05-14;15(7):730-737. 2018-05-14 [PMID: 29910678] (Human)
• S Zelzer, F Tatzber, M Herrmann, W Wonisch, S Rinnerhofe, M Kundi, B Obermayer-, T Niedrist, G Cvirn, G Wultsch, H Mangge Work Intensity, Low-Grade Inflammation, and Oxidative Status: A Comparison between Office and Slaughterhouse Workers Oxid Med Cell Longev, 2018-04-18;2018(0):2737563. 2018-04-18 [PMID: 29849876] (Human)
• A Venkatrama, P Callas, LA McClure, F Unverzagt, G Arora, V Howard, VG Wadley, M Cushman, P Arora Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites Alzheimers Dement (N Y), 2018-04-26;4(0):165-172. 2018-04-26 [PMID: 29756004] (Human)
• D Binas, H Daniel, A Richter, V Ruppert, KD Schlüter, B Schieffer, S Pankuweit The prognostic value of sST2 and galectin-3 considering different aetiologies in non-ischaemic heart failure Open Heart, 2018-02-26;5(1):e000750. 2018-02-26 [PMID: 29531765] (Human)
• S Özy?lmaz, MH Sat?lm??o?, M Gül, H Uyarel, OA Serdar Evaluation of the association between serum uric acid level andthe predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy Turk Kardiyol Dern Ars, 2018-03-01;46(2):111-120. 2018-03-01 [PMID: 29512627] (Human)
• A Salah, H Yoshifuji, S Ito, K Kitagori, K Kiso, N Yamada, T Nakajima, H Haga, T Tsuruyama, A Miyagawa-H High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach Patholog Res Int, 2017-05-16;2017(0):9312142. 2017-05-16 [PMID: 28593065] (Human)
• C Wojciechow, E Romuk, E Nowalany-K, W Jache? Serum Galectin-3 and ST2 as predictors of unfavorable outcome in stable dilated cardiomyopathy patients Hellenic J Cardiol, 2017-03-28;0(0):. 2017-03-28 [PMID: 28363768] (Human)
• XW He, WL Li, C Li, P Liu, YG Shen, M Zhu, XP Jin Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke Sci Rep, 2017-01-23;7(0):40994. 2017-01-23 [PMID: 28112232] (Human)
• Lin Y, Chou C, Wu X, Chang Y, Hung C, Chen Y, Tzeng Y, Wu V, Ho Y, Hsieh F, Wu K Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. PLoS ONE, 2014-09-02;9(9):e95254. 2014-09-02 [PMID: 25180794] (Human)
• Demmert M, Faust K, Bohlmann MK, Troger B, Gopel W, Herting E, Hartel C Galectin-3 in cord blood of term and preterm infants. Clin. Exp. Immunol., 2012-02-01;167(2):246-51. 2012-02-01 [PMID: 22236000] (Human)
• Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB Hypoxia potentiates glioma-mediated immunosuppression. PLoS ONE, 2011-01-20;6(1):e16195. 2011-01-20 [PMID: 21283755] (Human)

Bioinformatics

• Gene Symbol: LGALS3