Human IL-10 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human IL-10 Quantikine ELISA Kit Summary

• Background: The Quantikine Human IL-10 Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure IL-10 in cell culture supernates, serum, and plasma. It contains Sf 21-expressed recombinant human IL-10 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human IL-10 and does not cross-react with viral IL-10. Resu...lts obtained using natural human IL-10 showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate this kit can be used to determine relative mass values for natural human IL-10.
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• Specificity: Natural and recombinant human IL-10
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL10

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-10 Quantikine ELISA Kit

• CSIF
• CSIFMGC126450
• Cytokine synthesis inhibitory factor
• GVHDS
• IL10
• IL-10
• IL10A
• IL-10MGC126451
• interleukin 10
• interleukin-10
• TGIF

Background

Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL-10 alpha -helical cytokine family that also includes IL-19, IL-20, IL-22, IL-24, and IL-26/AK155 (1-3). IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells (4, 5). Mature human IL-10 shares 86% amino acid sequence identity with equine IL-10 and 72% - 80% with bovine, canine, feline, guinea pig, mouse, ovine, porcine, and rat IL-10. It contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently-associated homodimer (4, 6, 7). 

IL-10 mediates its biological activities through a heteromeric receptor complex composed of the type II cytokine receptor subunits IL-10 R alpha and IL-10 R beta . IL-10 R alpha is a 110 kDa transmembrane glycoprotein that is expressed on lymphocytes, NK cells, macrophages, monocytes, astrocytes, intestinal epithelial cells, cytotrophoblasts, and activated hepatic stellate cells (8-13), while the 75 kDa transmembrane IL-10 R beta is widely expressed (14, 15). The IL-10 dimer binds to two IL-10 R alpha chains, triggering recruitment of two IL-10 R beta chains (14, 15). IL-10 R beta does not bind IL-10 directly but is required for signal transduction. IL-10 R beta also associates with IL-20 R alpha , IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29 (16-18). 

The involvement of IL-10 in immunoregulation includes both suppressive and stimulatory effects. It functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells (19-21) and by promoting the development of M2 macrophages (21). Its expression by immunosuppressive regulatory T cells (Treg) and regulatory B cells is important for Treg proliferation (19). Within a tumor microrenvironment, however, IL-10 inhibits the expansion of Treg as well as myeloid-derived suppressor cells (22, 23). IL-10 induces the intratumoral accumulation and activation of CD8+ T cells (24, 25). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation (19) and promoting muscle regeneration after injury (21), but it also contributes to the persistence of viral infections (26). The levels of IL-10 are elevated in Sjogren's syndrome (saliva), primary CNS lymphoma (cerebrospinal fluid), and ovarian cancer (serum and ascites) (27-29). Its levels are decreased in the serum in patients with recurrent heart attacks or during preeclampsia and also in the seminal fluid of infertile men (30-32).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-10 (D1000B)(214)

Publications using D1000B

• Donate-Correa, J;Ferri, CM;Mora-Fernández, C;Pérez-Delgado, N;González-Luis, A;Navarro-González, JF; Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial Cardiovascular diabetology 2024-08-24 [PMID: 39182114] (Human)
• Chen, Y;Wang, L;Chen, N;Tang, G; Metformin induces tumor immunogenic cell death in ovarian cancer by activating AMPK pathway Translational oncology 2024-07-08 [PMID: 38981246] (Human)
• St?pie?, K;Siudut, J;Zalewski, J;Nowakowski, T;Undas, A; Elevated plasma factor XI is associated with postthrombotic syndrome Thrombosis research 2024-07-03 [PMID: 38968817] (Human)
• Kim, H;Park, HH;Kim, HN;Seo, D;Hong, KS;Jang, JG;Seo, EU;Kim, IY;Jeon, SY;Son, B;Cho, SW;Kim, W;Ahn, JH;Lee, W; The TOX-RAGE axis mediates inflammatory activation and lung injury in severe pulmonary infectious diseases Proceedings of the National Academy of Sciences of the United States of America 2024-06-25 [PMID: 38900789] (Human)
• Scovino, AM;Dahab, EC;Diniz-Lima, I;de Senna Silveira, E;Barroso, SPC;Cardoso, KM;Nico, D;Makhoul, GJ;da Silva-Junior, EB;Freire-de-Lima, CG;Freire-de-Lima, L;Fonseca, LMD;Valente, N;Nacife, V;Machado, A;Araújo, M;Vieira, GF;Pauvolid-Corrêa, A;Siqueira, M;Morrot, A; A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants Microorganisms 2024-04-02 [PMID: 38674664] (Human)
• Antuña, E;Potes, Y;Baena-Huerta, FJ;Cachán-Vega, C;Menéndez-Coto, N;Álvarez Darriba, E;Fernández-Fernández, M;Burgos Bencosme, N;Bermúdez, M;López Álvarez, EM;Gutiérrez-Rodríguez, J;Boga, JA;Caballero, B;Vega-Naredo, I;Coto-Montes, A;Garcia-Gonzalez, C; NLRP3 Contributes to Sarcopenia Associated to Dependency Recapitulating Inflammatory-Associated Muscle Degeneration International journal of molecular sciences 2024-01-24 [PMID: 38338718] (Human)
• Park, YJ;Acosta, D;Rubel Hoq, M;Khurana, S;Golding, H;Zaitseva, M; Pyrogenic and inflammatory mediators are produced by polarized M1 and M2 macrophages activated with D-dimer and SARS-CoV-2 spike immune complexes Cytokine 2024-01-01 [PMID: 38041875] (Human)
• Zou, Y;Guo, S;Liao, Y;Chen, W;Chen, Z;Chen, J;Wen, L;Xie, X; Ceramide metabolism-related prognostic signature and immunosuppressive function of ST3GAL1 in osteosarcoma Translational oncology 2023-11-28 [PMID: 38029509] (Human)
• Ur Rahim, J;Faheem, MM;Nawaz, S;Goswami, A;Rai, R; Synthesis and characterization of piperic acid conjugates with homochiral and heterochiral dipeptides containing phenylalanine and their application in skin cancer Peptides 2023-11-03 [PMID: 37923167] (Mouse)
• Tomaszewski, M;Mertowska, P;Janczewska, M;Stycze?, A;Mertowski, S;Jonas, K;Grywalska, E;Kope?, G; In the Search for Biomarkers of Pulmonary Arterial Hypertension, Are Cytokines IL-2, IL-4, IL-6, IL-10, and IFN-Gamma the Right Indicators to Use? International journal of molecular sciences 2023-09-05 [PMID: 37761997] (Human)
• Heo, SJ;Jee, YS; Intensity-effects of strengthening exercise on thigh muscle volume, pro- or anti-inflammatory cytokines, and immunocytes in the older adults: A randomized controlled trial Archives of gerontology and geriatrics 2023-07-23 [PMID: 37541052] (Human)
• A Alshalani, BM Beuger, AM Tuip-de Bo, R van Brugge, JP Acker, NP Juffermans The impact of biological age of red blood cell on in vitro endothelial activation markers Frontiers in Physiology, 2023-03-08;14(0):1127103. 2023-03-08 [PMID: 36969576] (Human)
• S Kameishi, CM Dunn, M Oka, K Kim, YK Cho, SU Song, DW Grainger, T Okano Rapid and effective preparation of clonal bone marrow-derived mesenchymal stem/stromal cell sheets to reduce renal fibrosis Scientific Reports, 2023-03-17;13(1):4421. 2023-03-17 [PMID: 36932137] (Human)
• AG Saleh, AY Shehab, R Abdul-Ghan, AF Allam, MM Osman, HS Ibrahim, HA El-Taweel, EA Moneer, NA Hagras, HF Farag Key cytokines and hematological parameters in patients with uncomplicated falciparum malaria in Hodeidah, Yemen Cytokine, 2023-02-27;164(0):156156. 2023-02-27 [PMID: 36857851] (Human)
• J Ferreira, M Oliveira, M Bicho, F Serejo Role of Inflammatory/Immune Response and Cytokine Polymorphisms in the Severity of Chronic Hepatitis C (CHC) before and after Direct Acting Antiviral (DAAs) Treatment International Journal of Molecular Sciences, 2023-01-10;24(2):. 2023-01-10 [PMID: 36674897] (Human)
• M Babi? Leko, M Mihel?i?, J Jurasovi?, M Nikolac Pe, E Špani?, A Sekovani?, T Orct, K Zub?i?, L Langer Hor, N Plei?, S Ki?emet-Pi, Ž Vogrinc, N Pivac, A Diana, F Borove?ki, PR Hof, G Šimi? Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease International Journal of Molecular Sciences, 2022-12-27;24(1):. 2022-12-27 [PMID: 36613911] (Human)
• SL Liao, MC Hua, MH Tsai, KW Su, C Lin, TC Yao, LC Chen, KW Yeh, JL Huang, SH Lai Association between Serum Zinc and Toll-like-Receptor- Related Innate Immunity and Infectious Diseases in Well-Nourished Children with a Low Prevalence of Zinc Deficiency: A Prospective Cohort Study Nutrients, 2022-12-19;14(24):. 2022-12-19 [PMID: 36558553] (Human)
• S Schulze, C Neuber, S Möller, U Hempel, LC Hofbauer, KD Schaser, J Pietzsch, S Rammelt Impact of Sulfated Hyaluronan on Bone Metabolism in Diabetic Charcot Neuroarthropathy and Degenerative Arthritis International Journal of Molecular Sciences, 2022-12-02;23(23):. 2022-12-02 [PMID: 36499493] (Human)
• G Della Came, T Liu, W Yang, Y Li, VF Puntes, S Gioria, P Italiani, D Boraschi Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles International Journal of Molecular Sciences, 2022-11-24;23(23):. 2022-11-24 [PMID: 36498992] (Human)
• C Cui, D Zhang, K Sun, Y Zhu, J Xu, Y Kang, G Zhang, Y Cai, S Mao, R Long, J Ma, S Dong, Y Sun Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor BMC immunology, 2022-11-25;23(1):58. 2022-11-25 [PMID: 36434505] (Human)
• J Wang, N Wang, Z Zheng, Y Che, M Suzuki, S Kano, J Lu, P Wang, Y Sun, A Homma Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma BMC Cancer, 2022-11-24;22(1):1208. 2022-11-24 [PMID: 36424539] (Human)
• W Xu, P Berning, T Erdmann, M Grau, N Bettazová, M Zapukhlyak, F Frontzek, C Kosnopfel, P Lenz, M Grondine, B Willis, JT Lynch, P Klener, S Hailfinger, ST Barry, G Lenz mTOR inhibition amplifies the anti-lymphoma effect of PI3Kbeta/delta blockage in diffuse large B-cell lymphoma Leukemia, 2022-11-09;0(0):. 2022-11-09 [PMID: 36352190] (Human)
• CV Gonçalves, IS Ribeiro, MPL Galantini, IPR Muniz, PHB Lima, GS Santos, RAA da Silva Inflammaging and body composition: New insights in diabetic and hypertensive elderly men Experimental gerontology, 2022-10-28;170(0):112005. 2022-10-28 [PMID: 36341786] (Human)
• J Milosevic, M Jurisevic, V Grbovic, I Jovanovic, N Gajovic, A Jurisic-Sk Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study International Journal of Environmental Research and Public Health, 2022-09-13;19(18):. 2022-09-13 [PMID: 36141752] (Human)
• S Bou-Ghanna, K Kim, M Kondo, DW Grainger, T Okano Mesenchymal Stem Cell Sheet Centrifuge-Assisted Layering Augments Pro-Regenerative Cytokine Production Cells, 2022-09-12;11(18):. 2022-09-12 [PMID: 36139414] (Human)
• Z Wu, X Bai, Z Lu, S Liu, H Jiang LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination Journal of Immunology Research, 2022-09-09;2022(0):6450721. 2022-09-09 [PMID: 36118415] (Human)
• FE Rossi, AJ Maldonado, JM Cholewa, SLG Ribeiro, CA de Araújo, C Figueiredo, T Reichel, K Krüger, FS Lira, LG Minuzzi Exercise training-induced changes in immunometabolic markers in youth badminton athletes Scientific Reports, 2022-09-15;12(1):15539. 2022-09-15 [PMID: 36109571] (Human)
• F Piancone, F La Rosa, I Marventano, A Hernis, R Miglioli, F Trecate, M Saresella, M Clerici Modulation of Neuroendocrine and Immunological Biomarkers Following Rehabilitation in Sarcopenic Patients Cells, 2022-08-10;11(16):. 2022-08-10 [PMID: 36010554] (Human)
• MPL Galantini, IS Ribeiro, CV Gonçalves, IPR Muniz, PHB Lima, GS Santos, RAA da Silva The sweet fuel of inflammation: New perspectives on the complex web that interconnects diabetes Experimental gerontology, 2022-07-30;167(0):111905. 2022-07-30 [PMID: 35918042] (Human)
• H Gupta, SH Kim, SK Kim, SH Han, HC Kwon, KT Suk Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis Microorganisms, 2022-07-21;10(7):. 2022-07-21 [PMID: 35889193] (Human)
• Myles R. McCrary, Michael Q. Jiang, Kaleena Jesson, Xiaohuan Gu, Meghan T. Logun, Anika Wu et al. Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain Experimental Neurology 2022-11-01 [PMID: 35868359] (Human)
• P Hiengrach, W Panpetch, A Chindampor, A Leelahavan Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice Scientific Reports, 2022-06-04;12(1):9345. 2022-06-04 [PMID: 35661720] (Human)
• A Gidaro, R Manetti, AP Delitala, MJ Soloski, G Lamberteng, D Castro, D Soldini, R Castelli Incidence of Venous Thromboembolism in Multiple Myeloma Patients across Different Regimens: Role of Procoagulant Microparticles and Cytokine Release Journal of Clinical Medicine, 2022-05-11;11(10):. 2022-05-11 [PMID: 35628848] (Human)
• E Martín-Núñ, A Pérez-Cast, VG Tagua, C Hernández-, C Ferri, N Pérez-Delg, S Rodríguez-, P Cerro-Lópe, Á López-Cast, A Delgado-Mo, VC López-Tarr, MA Arévalo-Gó, A González-L, A Martín-Oli, CC Morales-Es, C Mora-Ferná, J Donate-Cor, JF Navarro-Go Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular disease Scientific Reports, 2022-05-19;12(1):8422. 2022-05-19 [PMID: 35590090] (Human)
• HS Park, AM Abd El-Aty, JH Jeong, T Lee, TW Jung Capmatinib suppresses LPS-induced interaction between HUVECs and THP-1 monocytes through suppression of inflammatory responses Biomedical journal, 2022-04-26;0(0):. 2022-04-26 [PMID: 35483573] (Human)
• LG Minuzzi, FS Lira, RAB de Poli, VH Fialho Lop, AM Zagatto, K Suzuki, BM Antunes High-intensity intermittent exercise induces a potential anti-inflammatory response in healthy women across the menstrual cycle Cytokine, 2022-04-08;154(0):155872. 2022-04-08 [PMID: 35405482] (Human)
• C Feng, L Kou, P Yin, Y Jing Excessive activation of IL-33/ST2 in cancer-associated fibroblasts promotes invasion and metastasis in ovarian cancer Oncology Letters, 2022-03-17;23(5):158. 2022-03-17 [PMID: 35399326] (Human)
• A Weber, A Schwiebs, H Solhaug, J Stenvik, AM Nilsen, M Wagner, B Relja, HH Radeke Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells Environment international, 2022-03-15;163(0):107173. 2022-03-15 [PMID: 35303527] (Human)
• D Martins, O Dipasquale, K Davies, E Cooper, J Tibble, M Veronese, M Frigo, SCR Williams, F Turkheimer, M Cercignani, NA Harrison Transcriptomic and cellular decoding of functional brain connectivity changes reveal regional brain vulnerability to pro- and anti-inflammatory therapies Brain, Behavior, and Immunity, 2022-03-05;102(0):312-323. 2022-03-05 [PMID: 35259429] (Human)
• NJ Toney, LM Opdenaker, K Cicek, L Frerichs, CR Kennington, S Oberly, H Archinal, R Somasundar, J Sims-Mourt Tumor-B-cell interactions promote isotype switching to an immunosuppressive IgG4 antibody response through upregulation of IL-10 in triple negative breast cancers Journal of Translational Medicine, 2022-03-07;20(1):112. 2022-03-07 [PMID: 35255925] (Human)
• C Stene, A Röme, I Palmquist, C Linninge, G Molin, S Ahrné, LB Johnson, B Jeppsson Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes BMC gastroenterology, 2022-03-05;22(1):100. 2022-03-05 [PMID: 35247974] (Human)
• B Orts, A Gutierrez, L Madero, L Sempere, R Frances, P Zapater Clinical and Immunological Factors Associated with Recommended Trough Levels of Adalimumab and Infliximab in Patients with Crohn's Disease Frontiers in Pharmacology, 2022-01-03;12(0):795272. 2022-01-03 [PMID: 35046819] (Human)
• JQ Liu, XR Geng, TY Hu, LH Mo, XQ Luo, SY Qiu, DB Liu, ZG Liu, JB Shao, ZQ Liu, PC Yang Glutaminolysis is required in maintaining immune regulatory functions in B cells Mucosal Immunology, 2022-01-10;0(0):. 2022-01-10 [PMID: 35013572] (Human)
• R Lievin, H Hendel-Cha, A Baldé, R Lancar, M Algarte-Gé, R Krzysiek, D Costagliol, L Assoumou, Y Taoufik, C Besson Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma Cancers, 2021-12-28;14(1):. 2021-12-28 [PMID: 35008292] (Human)
• U Çak?r, A Hajdara, B Széky, B Mayer, S Kárpáti, É Mezey, P Silló, G Szakács, A Füredi, Z Pós, B Érsek, M Sárdy, K Németh Mesenchymal-Stromal Cell-like Melanoma-Associated Fibroblasts Increase IL-10 Production by Macrophages in a Cyclooxygenase/Indoleamine 2,3-Dioxygenase-Dependent Manner Cancers, 2021-12-07;13(24):. 2021-12-07 [PMID: 34944793] (Human)
• MT Guagnano, C D'Angelo, D Caniglia, P Di Giovann, E Celletti, E Sabatini, L Speranza, M Bucci, F Cipollone, R Paganelli Improvement of Inflammation and Pain after Three Months' Exclusion Diet in Rheumatoid Arthritis Patients Nutrients, 2021-10-09;13(10):. 2021-10-09 [PMID: 34684536] (Human)
• N Gomez-Lope, V Garcia-Flo, PY Chin, HM Groome, MT Bijland, KR Diener, R Romero, SA Robertson Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury JCI Insight, 2021-10-08;6(19):. 2021-10-08 [PMID: 34622802] (Human)
• B Sikora, A Skubis-Sik, A Prusek, J Gola Paracrine activity of adipose derived stem cells on limbal epithelial stem cells Scientific Reports, 2021-10-07;11(1):19956. 2021-10-07 [PMID: 34620960] (Human)
• IS Ribeiro, ÍS Pereira, MPL Galantini, DP Santos, MF Teles, IPR Muniz, GS Santos, RAA Silva Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men Experimental gerontology, 2021-09-20;155(0):111558. 2021-09-20 [PMID: 34547405] (Human)
• C Yamashiro, K Tokuda, Y Kobayashi, F Higashijim, T Yoshimoto, M Ota, T Ogata, A Ashimori, M Kobayashi, M Hatano, SH Uchi, M Wakuta, S Teranishi, K Kimura Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10 Scientific Reports, 2021-08-09;11(1):16096. 2021-08-09 [PMID: 34373467] (Human)
• L Zheng, H Xu, Y Di, L Chen, J Liu, L Kang, L Gao ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis Journal of Translational Medicine, 2021-08-09;19(1):342. 2021-08-09 [PMID: 34372882] (Human)
• L Bertran, M Portillo-C, S Martínez, C Aguilar, M Lopez-Dupl, D Riesco, J Binetti, M Vives, F Sabench, D Del Castil, C Richart, T Auguet Expression of Jejunal Taste Receptors in Women with Morbid Obesity Nutrients, 2021-07-16;13(7):. 2021-07-16 [PMID: 34371946] (Human)
• J Donate-Cor, CM Ferri, E Martín-Núñ, N Pérez-Delg, A González-L, C Mora-Ferná, JF Navarro-Go Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease Scientific Reports, 2021-08-05;11(1):15877. 2021-08-05 [PMID: 34354161] (Human)
• RL Relf, BJ Lee, G Eichhorn, MS Flint, L Beale, N Maxwell Thermoregulation is not impaired in breast cancer survivors during moderate-intensity exercise performed in warm and hot environments Physiological Reports, 2021-07-01;9(14):e14968. 2021-07-01 [PMID: 34291605] (Human)
• DPS Lopes, IS Ribeiro, DC Santos, FMS Lima, AA Santos, DSP Souza, DN Lopes, AO Prado, ÍS Pereira, DP Santos, GS Santos, RAA Silva Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase Experimental gerontology, 2021-06-11;152(0):111449. 2021-06-11 [PMID: 34126225] (Human)
• SO Mousavi, R Mohammadi, F Amjadi, Z Zandieh, S Aghajanpou, K Aflatoonia, M Sabbaghian, M Eslami, T Madani, R Aflatoonia Immunological response of fallopian tube epithelial cells to spermatozoa through modulating cytokines and chemokines Journal of reproductive immunology, 2021-05-02;146(0):103327. 2021-05-02 [PMID: 34052728] (Human)
• F Van de Vel, DM Ouwens, AH Batens, Y Van Nieuwe, B Lapauw Divergent dynamics in systemic and tissue-specific metabolic and inflammatory responses during weight loss in subjects with obesity Cytokine, 2021-05-27;144(0):155587. 2021-05-27 [PMID: 34052657] (Human)
• L Avila, ML Neves, AR Abreu, CR Fiuza, L Fukusawa, N Meziat-Fil, AR Soares San Cognitive functional therapy (CFT) compared with core training exercise (CTE) in patients with failed back surgery syndrome (FBSS): A study protocol for a randomized controlled trial Journal of bodywork and movement therapies, 2020-09-14;26(0):428-434. 2020-09-14 [PMID: 33992278] (Human)
• HI Lee, WK Rhim, EY Kang, B Choi, JH Kim, DK Han A Multilayer Functionalized Drug-Eluting Balloon for Treatment of Coronary Artery Disease Pharmaceutics, 2021-04-23;13(5):. 2021-04-23 [PMID: 33922861] (Human)
• GA Lavranou, S Mentzelopo, P Katsaounou, I Siempos, I Kalomenidi, A Geranaki, C Routsi, S Zakynthino Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? Journal of Clinical Medicine, 2021-04-07;10(8):. 2021-04-07 [PMID: 33917002] (Human)
• F La Rosa, S Agostini, M Saresella, AS Costa, F Piancone, R Miglioli, F Trecate, M Clerici Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation Journal of Translational Medicine, 2021-04-26;19(1):172. 2021-04-26 [PMID: 33902634] (Human)
• RLI Crake, MR Strother, E Phillips, MP Doogue, M Zhang, CMA Frampton, BA Robinson, MJ Currie Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study Scientific Reports, 2021-03-11;11(1):5648. 2021-03-11 [PMID: 33707475] (Human)
• BK Jeong, JH Kim, MH Jung, KM Kang, YH Lee Cytokine Profiles of Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy with Regards to Radiation Pneumonitis Severity Journal of Clinical Medicine, 2021-02-11;10(4):. 2021-02-11 [PMID: 33670117] (Human)
• ML Matias, M Romao-Veig, VR Ribeiro, PR Nunes, VJ Gomes, AC Devides, VT Borges, GG Romagnoli, JC Peracoli, MT Peracoli Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-&kappaB pathway in monocytes from pregnant women with preeclampsia Journal of reproductive immunology, 2021-02-05;144(0):103286. 2021-02-05 [PMID: 33578174] (Human)
• CS Oh, JM Choi, EH Park, L Piao, HJ Park, KY Rhee, SH Kim Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial BioMed Research International, 2021-01-23;2021(0):8880267. 2021-01-23 [PMID: 33564684] (Human)
• P Shrestha, DA Davis, HK Jaeger, A Stream, AI Aisabor, R Yarchoan Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2 PloS Pathogens, 2021-01-07;17(1):e1009091. 2021-01-07 [PMID: 33411730] (Human)
• J Chang, W Zhang, G Lin, D Tong, D Zhu, J Zhao, Q Yu, D Huang, W Li Tumor Response to Irinotecan is Associated with IL-10 Expression Level in Metastatic Colorectal Cancer-Results from mCRC Biomarker Study Onco Targets Ther, 2020-11-17;13(0):11819-11826. 2020-11-17 [PMID: 33235468] (Human)
• J Koh, JY Hur, KY Lee, MS Kim, JY Heo, BM Ku, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn Regulatory (FoxP3+) T cells and TGF-&beta predict the response to anti-PD-1 immunotherapy in patients with non-small cell lung cancer Sci Rep, 2020-11-04;10(1):18994. 2020-11-04 [PMID: 33149213] (Human)
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• Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 2009-03-09;206(3):535-48. 2009-03-09 [PMID: 19273625] (Human)
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• Chase JC, Celli J, Bosio CM Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. Infect. Immun., 2008-11-03;77(1):180-95. 2008-11-03 [PMID: 18981246] (Human)
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• Aranha CC, Gupta SM, Reddy KV Assessment of cervicovaginal cytokine levels following exposure to microbicide Nisin gel in rabbits. Cytokine, 2008-05-29;43(1):63-70. 2008-05-29 [PMID: 18513989] (Rabbit)
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• Kourea K, Parissis JT, Farmakis D, Panou F, Paraskevaidis I, Venetsanou K, Filippatos G, Kremastinos DT Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failure. Atherosclerosis, 2007-11-07;199(1):215-21. 2007-11-07 [PMID: 17991471] (Human)
• Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis. Cytokine, 2007-10-29;40(2):128-34. 2007-10-29 [PMID: 17911026] (Human)
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• Ferrandina G, Ranelletti FO, Legge F, Salutari V, Martinelli E, Fattorossi A, Lorusso D, Zannoni G, Vellone V, Paglia A, Scambia G Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer. Clin. Cancer Res., 2006-04-01;12(7):2055-60. 2006-04-01 [PMID: 16609015] (Human)
• Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Scholmerich J, Neumann E, Muller-Ladner U The potential of adiponectin in driving arthritis. J. Immunol., 2006-04-01;176(7):4468-78. 2006-04-01 [PMID: 16547285] (Human)
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• Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM, Piccirillo CA, Rehermann B Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood, 2006-02-14;107(11):4424-32. 2006-02-14 [PMID: 16478885] (Primate - Pan troglodytes (Chimpanzee))
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• Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock, 2005-10-01;24(4):332-5. 2005-10-01 [PMID: 16205317] (Primate - Papio hamadryas (Hamadyras Baboon))
• Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Human)
• Mistchenko AS, Fornari MC, Viegas M, Barrero PR, Diez RA Detection of interleukin 10 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis. J. Neurovirol., 2005-02-01;11(1):66-9. 2005-02-01 [PMID: 15804961] (Human)
• Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome. Microbes Infect., 2005-02-24;7(3):427-36. 2005-02-24 [PMID: 15784184] (Human)
• Chung HL, Kim WT, Kim JK, Choi EJ, Lee JH, Lee GH, Kim SG Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. Ann. Allergy Asthma Immunol., 2005-02-01;94(2):267-72. 2005-02-01 [PMID: 15765744] (Human)
• Pitzurra L, Bellocchio S, Nocentini A, Bonifazi P, Scardazza R, Gallucci L, Stracci F, Simoncelli C, Bistoni F, Romani L Antifungal immune reactivity in nasal polyposis. Infect. Immun., 2004-12-01;72(12):7275-81. 2004-12-01 [PMID: 15557653] (Human)
• Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J. Immunol., 2004-10-01;173(7):4433-42. 2004-10-01 [PMID: 15383574] (Human)
• Saeki S, Matsuse H, Kondo Y, Machida I, Kawano T, Tomari S, Obase Y, Fukushima C, Kohno S Effects of antiasthmatic agents on the functions of peripheral blood monocyte-derived dendritic cells from atopic patients. J. Allergy Clin. Immunol., 2004-09-01;114(3):538-44. 2004-09-01 [PMID: 15356554] (Human)
• Hayakata T, Shiozaki T, Tasaki O, Ikegawa H, Inoue Y, Toshiyuki F, Hosotubo H, Kieko F, Yamashita T, Tanaka H, Shimazu T, Sugimoto H Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock, 2004-08-01;22(2):102-7. 2004-08-01 [PMID: 15257081] (Human)
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• Chuang CC, Hung CJ, Tsai MC, Chuang YC High concentrations of circulating macrophage migration inhibitory factor in patients with severe blunt trauma: Is serum macrophage migration inhibitory factor concentration a valuable prognostic factor? Crit. Care Med., 2004-03-01;32(3):734-9. 2004-03-01 [PMID: 15090955] (Human)
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• Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries. J. Androl., 2004-03-01;25(2):250-4. 2004-03-01 [PMID: 14760011] (Human)
• Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright AL TGF-beta in human milk is associated with wheeze in infancy. J. Allergy Clin. Immunol., 2003-10-01;112(4):723-8. 2003-10-01 [PMID: 14564350] (Human)
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• Messmer D, Jacque JM, Santisteban C, Bristow C, Han SY, Villamide-Herrera L, Mehlhop E, Marx PA, Steinman RM, Gettie A, Pope M Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells. J. Immunol., 2002-10-15;169(8):4172-82. 2002-10-15 [PMID: 12370346] (Human)
• Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K Cytokine profile in Behcet&#039;s disease patients. Relationship with disease activity. Scand. J. Rheumatol., 2002-01-01;31(4):205-10. 2002-01-01 [PMID: 12369651] (Human)
• D&amp;apos;Ambrosio D Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes. Eur. J. Immunol., 2002-10-01;32(10):2934-43. 2002-10-01 [PMID: 12355447] (Human)
• Baroni A, Perfetto B, Ruocco E, Greco R, Criscuolo D, Ruocco V Cytokine pattern in blister fluid and sera of patients with pemphigus. Dermatology (Basel), 2002-01-01;205(2):116-21. 2002-01-01 [PMID: 12218224] (Human)
• Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma. Int. J. Cancer, 2002-09-10;101(2):183-9. 2002-09-10 [PMID: 12209996] (Human)
• Lazetic S, Leong SR, Chang JC, Ong R, Dawes G, Punnonen J Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells. J. Biol. Chem., 2002-08-06;277(41):38660-8. 2002-08-06 [PMID: 12167647] (Human)
• Jotwani R, 175, Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, Banchereau J, Cutler CW Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies. 2001-10-15;167(8):4693-700. 2001-10-15 [PMID: 11591800] (Human)
• Tangri S, Ishioka GY, Huang X, Sidney J, Southwood S, Fikes J, Sette A Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide. J. Exp. Med., 2001-09-17;194(6):833-46. 2001-09-17 [PMID: 11560998] (Human)
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Bioinformatics

• Gene Symbol: IL10