Human IL-2 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human IL-2 Quantikine ELISA Kit Summary

• Background: The Quantikine Human IL-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-2 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-2 and antibodies raised against recombinant human IL-2. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IL-2 showed do...se response curves that were parallel to the standard curves obtained using the recombinant Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-2.
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• Specificity: Natural and recombinant human IL-2.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-2 Quantikine ELISA Kit

• Aldesleukin
• IL2
• IL-2
• IL-2lymphokine
• interleukin 2
• interleukin-2
• involved in regulation of T-cell clonal expansion
• Proleukin
• T cell growth factor
• T-cell growth factor
• TCGF

Background

Interleukin 2 (IL-2), also known as T cell growth factor (TCGF), is a 15-18 kDa variably glycosylated alpha -helical polypeptide that is a member of the Common gamma Chain ( gamma c) cytokine family (1-4). It exists as a monomer and has a notably short half-life (< 30 minutes) (1). Human IL-2 is synthesized as a 153 amino acid (aa) precursor that contains a 20 aa signal sequence plus a 133 aa mature region (5, 6). The mature region is alpha -helical in nature, and contains one utilized O-linked glycosylation site at Thr3 plus three cysteines, two of which form an intrachain disulfide bond that is essential for activity (7). Mature human IL-2 shares 73%, 66%, 78% and 97% aa identity with canine, rat, feline and rhesus monkey IL-2, respectively. Although human IL-2 shares only approximately 60% aa identity with the highly polymorphic mouse IL-2, human IL-2 is known to be active on mouse IL-2 responsive cells. Cells reported to secrete IL-2 include gamma δ T cells (8), activated conventional CD4+ and CD8+ T cells (1, 9), neurons (10, 11), microglia (12), and hematopoietic stem cells (13). 

The receptor for IL-2 (IL-2 R) is composed of three subunits, the 55 kDa CD25/IL-2 R alpha chain, the 70 kDa IL-2 R beta chain, and the 65 kDa Common gamma Chain (1, 3). IL-2 first binds to CD25, the binary complex then recruits IL-2 R beta and gamma c to form the quaternary signaling complex (1, 14). In addition to IL-2, IL-2 R beta is used by IL-15 in its quaternary signaling complex. gamma c also serves as a signaling receptor for IL-4, -7, -9, -15, and -21 (1, 3). 

In vitro studies have shown an important role for IL-2 in T cell activation and expansion. In vivo, IL-2 is critical for the development, maintenance and function of regulatory T cells (Treg) which provide protection against autoimmune disease. On the other hand, IL-2 can also promote autoimmune inflammation in target organs through its roles in regulating the expression of T cell trafficking genes, and production of Th2 cytokines. Within the CD8+ T cell subset, IL-2 is essential for optimal primary responses and differentiation into terminal effector cells. IL-2 also promotes the development of activated CD8+ T cells into memory cells. (1).

&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-2 (D2050)(93)

Publications using D2050

• Abbasifard, M;Kazerooni, K;Taghipour Khaje Sharifi, G;Bagheri-Hosseinabadi, Z;Hajizadeh, MR; Influence of blood trace elements on immune responses and adverse symptoms subsequent to Sinopharm COVID-19 vaccination Scientific reports 2024-11-27 [PMID: 39604541] (Human)
• Xu, X;Yan, SL;Yo, YT;Chiang, P;Tsai, CY;Lin, LL;Qin, A; A Novel Monoclonal Antibody against PD-1 for the Treatment of Viral Oncogene-Induced Tumors or Other Cancer Cancers 2024-09-01 [PMID: 39272910] (Human)
• Chen, S;Nguyen, TD;Lee, KZ;Liu, D; Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies Biotechnology advances 2024-08-19 [PMID: 39168355] (Human)
• Chakraborty, A;Onda, M;O'Shea, T;Wei, J;Liu, X;Bera, TK;Pastan, I; A bispecific antibody that targets the membrane-proximal region of mesothelin and retains high anticancer activity in the presence of shed mesothelin Molecular cancer therapeutics 2024-04-22 [PMID: 38647528] (Human)
• Abbasifard, M;Dehghan Banadaki, M;Taghipour Khaje Sharifi, G;Rahnama, A;Bagheri-Hosseinabadi, Z; Serum Dehydroepiandrosterone sulfate (DHEA-S) level and its potential impact on immune responses and symptom severity after Oxford-AstraZeneca COVID-19 vaccination International immunopharmacology 2024-04-12 [PMID: 38615381] (Human)
• Tomaszewski, M;Mertowska, P;Janczewska, M;Stycze?, A;Mertowski, S;Jonas, K;Grywalska, E;Kope?, G; In the Search for Biomarkers of Pulmonary Arterial Hypertension, Are Cytokines IL-2, IL-4, IL-6, IL-10, and IFN-Gamma the Right Indicators to Use? International journal of molecular sciences 2023-09-05 [PMID: 37761997] (Human)
• Abramiuk, M;Frankowska, K;Ku?ak, K;Tarkowski, R;Mertowska, P;Mertowski, S;Grywalska, E; Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis International journal of molecular sciences 2023-04-24 [PMID: 37175494] (Human)
• G Silva, AF Rodrigues, S Ferreira, C Matos, RP Eleutério, G Marques, K Kucheryava, AR Lemos, PMF Sousa, R Castro, A Barbas, D Simão, PM Alves Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors Biomolecules, 2023-03-02;13(3):. 2023-03-02 [PMID: 36979394] (Human)
• R Yoshida, M Saigi, T Tani, BF Springer, H Shibata, S Kitajima, NR Mahadevan, M Campisi, W Kim, Y Kobayashi, TC Thai, K Haratani, Y Yamamoto, SK Sundararam, EH Knelson, A Vajdi, I Canadas, R Uppaluri, CP Paweletz, JJ Miret, PH Lizotte, PC Gokhale, PA Janne, DA Barbie MET-induced CD73 restrains STING-mediated immunogenicity of EGFR-mutant lung cancer Cancer Research, 2022-11-02;0(0):. 2022-11-02 [PMID: 36066413] (Human)
• S Tomar, J Zhang, M Khanal, J Hong, A Venugopala, Q Jiang, M Sengupta, M Miettinen, N Li, I Pastan, M Ho, R Hassan Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors Molecular Cancer Therapeutics, 2022-07-05;21(7):1195-1206. 2022-07-05 [PMID: 35499461] (Mouse)
• J Tian, W Wang, J Zhu, Y Zhuang, C Qi, Z Cai, W Yan, W Lu, A Shang Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway Journal of Immunology Research, 2022-04-20;2022(0):4012920. 2022-04-20 [PMID: 35497876] (Human)
• AJ Martinko, EF Simonds, S Prasad, A Ponce, CJ Bracken, J Wei, YH Wang, TL Chow, Z Huang, MJ Evans, JA Wells, ZB Hill Switchable assembly and function of antibody complexes in�vivo using a small molecule Proceedings of the National Academy of Sciences of the United States of America, 2022-03-01;119(9):. 2022-03-01 [PMID: 35210365] (Human)
• JP Bikorimana, J Abusarah, N Salame, N El-Hachem, R Shammaa, M Rafei Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes Cells, 2022-02-09;11(4):. 2022-02-09 [PMID: 35203247] (Mouse)
• Y Han, L Wang, Q Li, H Chen, X Ma LncRNA NEAT1 is upregulated in recurrent aphthous stomatitis (RAS) and has predictive values BMC Oral Health, 2021-12-31;21(1):673. 2021-12-31 [PMID: 34972503] (Human)
• WS Khalaf, MRA Mahmoud, WF Elkhatib, HR Hashem, WE Soliman Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage Heliyon, 2021-11-16;7(11):e08409. 2021-11-16 [PMID: 34849421] (Human)
• K Kurianowic, M Klatka, A Polak, A Hymos, D B?bnowska, M Podgajna, R Hrynkiewic, O Sierawska, P Nied?wiedz Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes-Focus on Toll-like Receptors Expression International Journal of Molecular Sciences, 2021-11-09;22(22):. 2021-11-09 [PMID: 34830017] (Human)
• F Rancan, X Guo, K Rajes, P Sidiropoul, F Zabihi, L Hoffmann, S Hadam, U Blume-Peyt, E Rühl, R Haag, A Vogt Topical Delivery of Rapamycin by Means of Microenvironment-Sensitive Core-Multi-Shell Nanocarriers: Assessment of Anti-Inflammatory Activity in an ex vivo Skin/T Cell Co-Culture Model International Journal of Nanomedicine, 2021-10-22;16(0):7137-7151. 2021-10-22 [PMID: 34712046] (Human)
• B Sikora, A Skubis-Sik, A Prusek, J Gola Paracrine activity of adipose derived stem cells on limbal epithelial stem cells Scientific Reports, 2021-10-07;11(1):19956. 2021-10-07 [PMID: 34620960] (Human)
• J Kolodziejc, S Kozachok, ? Pecio, S Marchyshyn, W Oleszek Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects Phytochemistry, 2021-07-27;190(0):112861. 2021-07-27 [PMID: 34325241] (Human)
• M Tomori, T Nagamine, T Miyamoto, M Iha Effects of Ingesting Fucoidan Derived from Cladosiphon okamuranus Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study Marine Drugs, 2021-06-15;19(6):. 2021-06-15 [PMID: 34203925] (Human)
• Li Zhang, Bei Zhang, Linjing Wang, Mingwu Lou, Yunxia Shen Huanglian‑Houpo drug combination ameliorates H1N1‑induced mouse pneumonia via cytokines, antioxidant factors and TLR/MyD88/NF‑ kappa B signaling pathways Experimental and Therapeutic Medicine 2021-02-26 [PMID: 33747167] (Mouse)
• P Shrestha, DA Davis, HK Jaeger, A Stream, AI Aisabor, R Yarchoan Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2 PloS Pathogens, 2021-01-07;17(1):e1009091. 2021-01-07 [PMID: 33411730] (Human)
• C Le Guilche, T Luyten, JB Parys, M Pucheault, O Dellis Synthesis and Characterization of Store-Operated Calcium Entry Inhibitors Active in the Submicromolar Range International Journal of Molecular Sciences, 2020-12-21;21(24):. 2020-12-21 [PMID: 33371518] (Human)
• T Phillips, L Huitema, R Cepeda, DL Cobos, RIM Perez, MS Garza, F Ringpfeil, B Dasgeb, J Uitto, JC Salas-Alan, V Alexeev, O Igoucheva Aberrant recruitment of leukocytes defines poor wound healing in patients with recessive dystrophic epidermolysis bullosa J Dermatol Sci, 2020-10-17;0(0):. 2020-10-17 [PMID: 33143962] (Human)
• Gao Y, Sun W, Cha X, Wang H &#039;Psoriasis 1&#039; reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation. Int J Mol Med, 2020-08-06;46(4):1538-1550. 2020-08-06 [PMID: 32945358] (Human)
• A Sa?kowska, K Kara?, I Karwaciak, A Walczak-Dr, M Krawczyk, M Sobalska-K, J Dastych, M Ratajewski Identification of Novel Molecular Markers of Human Th17 Cells Cells, 2020-07-03;9(7):. 2020-07-03 [PMID: 32635226] (Human)
• M Tomaszewsk, E Grywalska, A Tomaszewsk, P B?aszczak, M Kurzyna, J Roli?ski, G Kope? Overexpression of PD-1 on Peripheral Blood Lymphocytes in Patients with Idiopathic Pulmonary Arterial Hypertension and Its Association with High Viral Loads of Epstein-Barr Virus and Poor Clinical Parameters J Clin Med, 2020-06-24;9(6):. 2020-06-24 [PMID: 32599687] (Human)
• M Herrera, C Vera, Y Keynan, ZV Rueda Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review J Immunol Res, 2020-04-21;2020(0):8074183. 2020-04-21 [PMID: 32377537] (Human)
• R Wang, K Huang CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL?2 and TGF?&amp;beta by CD4+ T�cells via the STAT5 signaling pathway Mol Med Rep, 2020-04-01;0(0):. 2020-04-01 [PMID: 32323817] (Human)
• Z Mei, K Zhang, AK Lam, J Huang, F Qiu, B Qiao, Y Zhang MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma Cancer Med, 2019-12-04;0(0):. 2019-12-04 [PMID: 31800160] (Human)
• Y Lu, BK Yoo, AHC Ng, J Kim, S Yeom, J Tang, MM Lin, AH Zewail, JR Heath 4D electron microscopy of T cell activation Proc. Natl. Acad. Sci. U.S.A., 2019-10-14;116(44):22014-22019. 2019-10-14 [PMID: 31611413] (Human)
• DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lope, M Kawahara, AM Freund, F Rodier, JD Wu, PY Desprez, DH Raulet, PS Nelson, LJ van 't Vee, J Campisi, JP Coppé Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging JCI Insight, 2019-06-11;5(0):. 2019-06-11 [PMID: 31184599] (Human)
• EJ Im, CH Lee, PG Moon, GG Rangaswamy, B Lee, JM Lee, JC Lee, JG Jee, JS Bae, TK Kwon, KW Kang, MS Jeong, JE Lee, HS Jung, HJ Ro, S Jun, W Kang, SY Seo, YE Cho, BJ Song, MC Baek Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A Nat Commun, 2019-03-27;10(1):1387. 2019-03-27 [PMID: 30918259] (Human)
• SA Farhadi, E Bracho-San, MM Fettis, DT Seroski, SL Freeman, A Restuccia, BG Keselowsky, GA Hudalla Locally anchoring enzymes to tissues via extracellular glycan recognition Nat Commun, 2018-11-22;9(1):4943. 2018-11-22 [PMID: 30467349] (Human)
• JH Kim, SJ Jang, JW Yun, MH Jung, SH Woo Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro PLoS ONE, 2018-11-08;13(11):e0207090. 2018-11-08 [PMID: 30408092] (Human)
• Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V VSIG-3 as a ligand of VISTA inhibits human T-cell function. Immunology, 2018-10-10;156(1):74-85. 2018-10-10 [PMID: 30220083] (Human)
• A Rajamanick, S Munisankar, Y Bhootra, CK Dolla, K Thiruvenga, TB Nutman, S Babu Altered levels of memory T cell subsets and common ?c cytokines in Strongyloides stercoralis infection and partial reversal following anthelmintic treatment PLoS Negl Trop Dis, 2018-05-24;12(5):e0006481. 2018-05-24 [PMID: 29795573] (Human)
• T Tsai, S Kuehn, N Tsiampalis, MK Vu, V Kakkassery, G Stute, HB Dick, SC Joachim Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients PLoS ONE, 2018-03-27;13(3):e0194603. 2018-03-27 [PMID: 29584759] (Human)
• X Liu, L Zeng, Z Zhao, Y Xie, S Wang, J Zhang, Y He, Z Zou, J Zhang, A Tao Construction, Expression, and Characterization of rSEA-EGF and In Vitro Evaluation of its Antitumor Activity Against Nasopharyngeal Cancer Technol. Cancer Res. Treat., 2018-01-01;17(0):1533033818762. 2018-01-01 [PMID: 29551087] (Human)
• G Jordakieva, I Grabovac, E Valic, KE Schmidt, A Graff, A Schuster, K Hoffmann-S, C Oberhuber, O Scheiner, A Goll, J Godnic-Cva Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects J Occup Med Toxicol, 2018-02-03;13(0):5. 2018-02-03 [PMID: 29434649] (ELISA Capture, Human)
• Z Ou, Y He, L Qi, X Zu, L Wu, Z Cao, Y Li, L Liu, DA Dube, Z Wang, L Wang Infiltrating mast cells enhance benign prostatic hyperplasia through IL-6/STAT3/Cyclin D1 signals Oncotarget, 2017-07-22;8(35):59156-59164. 2017-07-22 [PMID: 28938626] (Human)
• JS Cho, MH Lee, SI Kim, S Park, HS Park, E Oh, JH Lee, BN Koo The Effects of Perioperative Anesthesia and Analgesia on Immune Function in Patients Undergoing Breast Cancer Resection: A Prospective Randomized Study Int J Med Sci, 2017-08-18;14(10):970-976. 2017-08-18 [PMID: 28924368] (Human)
• HJ Park, HS Lee Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial Nutr Res Pract, 2017-06-09;11(4):290-299. 2017-06-09 [PMID: 28765775] (Human)
• GN Pandey, HS Rizavi, H Zhang, X Ren Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients Schizophr. Res., 2017-05-02;0(0):. 2017-05-02 [PMID: 28476335] (Human)
• NP Kumar, VV Banurekha, D Nair, S Babu Diminished plasma levels of common ?-chain cytokines in pulmonary tuberculosis and reversal following treatment PLoS ONE, 2017-04-27;12(4):e0176495. 2017-04-27 [PMID: 28448542] (Human)
• WP Fung-Leung, W Edwards, Y Liu, K Ngo, J Angsana, G Castro, N Wu, X Liu, RV Swanson, AD Wickenden T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers PLoS ONE, 2017-01-20;12(1):e0170102. 2017-01-20 [PMID: 28107393] (Human)
• The Suppressed Induction of Human Mature Cytotoxic T Lymphocytes Caused by Asbestos Is Not due to Interleukin-2 Insufficiency J Immunol Res, 2016-11-15;2016(0):7484872. 2016-11-15 [PMID: 27975069] (Human)
• Rehab M El-Gharaba Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis Biomed. Pharmacother, 2016-12-05;85(0):141-147. 2016-12-05 [PMID: 27930978] (Human)
• Junfeng Liu Human amniotic epithelial cells inhibit CD4+ T cell activation in acute kidney injury patients by influencing the miR-101-c-Rel-IL-2 pathway Mol. Immunol, 2016-11-26;81(0):76-84. 2016-11-26 [PMID: 27898347] (Human)
• Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome J Immunol, 2016-08-10;197(5):1621-30. 2016-08-10 [PMID: 27511738] (Human)
• Magrinelli F, Briani C, Romano M, Ruggero S, Toffanin E, Triolo G, Peter G, Praitano M, Lauriola M, Zanette G, Tamburin S The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy. J Diabetes Res, 2015-04-16;2015(0):547834. 2015-04-16 [PMID: 25961054] (Human)
• Lhuillier C, Barjon C, Niki T, Gelin A, Praz F, Morales O, Souquere S, Hirashima M, Wei M, Dellis O, Busson P Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION. J Biol Chem, 2015-05-06;290(27):16797-811. 2015-05-06 [PMID: 25947381] (Human)
• Yost E, Hynes T, Hartle C, Ott B, Berlot C Inhibition of G-protein betagamma signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cells. PLoS ONE, 2015-01-28;10(1):e0116575. 2015-01-28 [PMID: 25629163] (Human)
• Han L, Liu F, Li R, Li Z, Chen X, Zhou Z, Zhang X, Hu T, Zhang Y, Young K, Sun S, Wen J, Zhang M Role of programmed death ligands in effective T-cell interactions in extranodal natural killer/T-cell lymphoma. Oncol Lett, 2014-07-17;8(4):1461-1469. 2014-07-17 [PMID: 25202350] (Human)
• Zeng L, Maruyama S, Nakamura K, Parker-Duffen J, Adham I, Zhong X, Lee H, Querfurth H, Walsh K The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis. Skelet Muscle, 2014-08-04;4(0):16. 2014-08-04 [PMID: 25161767] (Human)
• Edwards W, Fung-Leung W, Huang C, Chi E, Wu N, Liu Y, Maher M, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson R, Wickenden A Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life. J Biol Chem, 2014-06-17;289(33):22704-14. 2014-06-17 [PMID: 24939846] (Human)
• Anthony , Kim, More , Abhijit, Zhang , Xiaoliu Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators. PLoS ONE, 2014-04-22;9(4):e95790. 2014-04-22 [PMID: 24755922] (Human)
• Poltorak M, Meinert I, Stone J, Schraven B, Simeoni L Sos1 regulates sustained TCR-mediated Erk activation. Eur J Immunol, 2014-02-20;44(5):1535-40. 2014-02-20 [PMID: 24497027] (Human)
• Manrique M, Kozlowski P, Cobo-Molinos A, Wang S, Wilson R, Montefiori D, Carville A, Aldovini A Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes. J Virol, 2013-02-13;87(8):4738-50. 2013-02-13 [PMID: 23408627] (Human)
• Churchman SM, Geiler J, Parmar R, Horner EA, Church LD, Emery P, Buch MH, McDermott MF, Ponchel F Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor. Clin. Exp. Rheumatol., 2012-08-29;30(4):534-42. 2012-08-29 [PMID: 22704737] (Human)
• Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system. PLoS ONE, 2011-09-13;6(9):e24751. 2011-09-13 [PMID: 21931843] (Human)
• Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis. Am. J. Pathol., 2011-02-01;178(2):744-53. 2011-02-01 [PMID: 21281807] (Human)
• Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells. Leukemia, 2010-11-19;25(1):161-8. 2010-11-19 [PMID: 21102427] (Human)
• Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation, 2009-11-15;88(9):1109-16. 2009-11-15 [PMID: 19898207] (Human)
• Tieu HV, Ananworanich J, Avihingsanon A, Apateerapong W, Sirivichayakul S, Siangphoe U, Klongugkara S, Boonchokchai B, Hammer SM, Manosuthi W Immunologic markers as predictors of tuberculosis-associated immune reconstitution inflammatory syndrome in HIV and tuberculosis coinfected persons in Thailand. AIDS Res. Hum. Retroviruses, 2009-11-01;25(11):1083-9. 2009-11-01 [PMID: 19886838] (Human)
• Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE CD200 is induced by ERK and is a potential therapeutic target in melanoma. J. Clin. Invest., 2007-12-01;117(12):3922-3929. 2007-12-01 [PMID: 18008004] (Human)
• Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis. Cytokine, 2007-10-29;40(2):128-34. 2007-10-29 [PMID: 17911026] (Human)
• Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy. AIDS Res. Hum. Retroviruses, 2007-07-01;23(7):886-90. 2007-07-01 [PMID: 17678471] (Human)
• Koivisto H, Hietala J, Anttila P, Niemela O Co-occurrence of IgA antibodies against ethanol metabolites and tissue transglutaminase in alcohol consumers: correlation with proinflammatory cytokines and markers of fibrogenesis. Dig. Dis. Sci., 2007-06-28;53(2):500-5. 2007-06-28 [PMID: 17597408] (Human)
• Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Carcinogenesis, 2006-12-20;28(5):1067-73. 2006-12-20 [PMID: 17183065] (Human)
• Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut, 2006-07-13;56(2):243-52. 2006-07-13 [PMID: 16840505] (Human)
• Bryan DL, Forsyth KD, Gibson RA, Hawkes JS Interleukin-2 in human milk: a potential modulator of lymphocyte development in the breastfed infant. Cytokine, 2006-04-11;33(5):289-93. 2006-04-11 [PMID: 16584887] (Human)
• Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M Influence of eotaxin 67G&gt;A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls. Atherosclerosis, 2006-02-28;189(2):458-63. 2006-02-28 [PMID: 16510147] (Human)
• Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J. Immunol., 2006-03-01;176(5):3000-9. 2006-03-01 [PMID: 16493058] (Human)
• Makis AC, Hatzimichael EC, Stebbing J, Bourantas KL C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease. Arch. Intern. Med., 2006-02-13;166(3):366-8. 2006-02-13 [PMID: 16476879] (Human)
• Sheikine Y, Bang CS, Nilsson L, Samnegard A, Hamsten A, Jonasson L, Eriksson P, Sirsjo A Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease. Atherosclerosis, 2005-12-27;188(2):462-6. 2005-12-27 [PMID: 16378611] (Human)
• Karenko L, Hahtola S, Paivinen S, Karhu R, Syrja S, Kahkonen M, Nedoszytko B, Kytölä S, Zhou Y, Blazevic V, Pesonen M, Nevala H, Nupponen N, Sihto H, Krebs I, Poustka A, Roszkiewicz J, Saksela K, Peterson P, Visakorpi T, Ranki A Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res., 2005-09-15;65(18):8101-10. 2005-09-15 [PMID: 16166283] (Human)
• Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome. Microbes Infect., 2005-02-24;7(3):427-36. 2005-02-24 [PMID: 15784184] (Human)
• Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection. Transpl. Int., 2005-02-01;18(2):177-85. 2005-02-01 [PMID: 15691270] (Human)
• Jensen J, Krakauer M, Sellebjerg F Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b. Cytokine, 2005-01-07;29(1):24-30. 2005-01-07 [PMID: 15579375] (Human)
• Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries. J. Androl., 2004-03-01;25(2):250-4. 2004-03-01 [PMID: 14760011] (Human)
• Saint F, Kurth N, Maille P, Vordos D, Hoznek A, Soyeux P, Patard JJ, Abbou CC, Chopin DK Urinary IL-2 assay for monitoring intravesical bacillus Calmette-Guerin response of superficial bladder cancer during induction course and maintenance therapy. Int. J. Cancer, 2003-11-10;107(3):434-40. 2003-11-10 [PMID: 14506744] (Human)
• Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma. Int. J. Cancer, 2002-09-10;101(2):183-9. 2002-09-10 [PMID: 12209996] (Human)
• Briard D, Brouty-Boye D, Azzarone B, Jasmin C Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. J. Immunol., 2002-05-01;168(9):4326-32. 2002-05-01 [PMID: 11970974] (Human)
• Pages F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debre B, Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer. Clin. Exp. Immunol., 2002-02-01;127(2):303-9. 2002-02-01 [PMID: 11876754] (Human)
• Gomez-Torres MJ, Acien P, Campos A, Velasco I Embryotoxicity of peritoneal fluid in women with endometriosis. Its relation with cytokines and lymphocyte populations. Hum. Reprod., 2002-03-01;17(3):777-81. 2002-03-01 [PMID: 11870135] (Human)
• Cotler SJ, Reddy KR, McCone J, Wolfe DL, Liu A, Craft TR, Ferris MW, Conrad AJ, Albrecht J, Morrissey M, Ganger DR, Rosenblate H, Blatt LM, Jensen DM, Taylor MW An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon. J. Interferon Cytokine Res., 2001-12-01;21(12):1011-9. 2001-12-01 [PMID: 11798458] (Human)
• Bovolenta C, Pilotti E, Mauri M, Turci M, Ciancianaini P, Fisicaro P, Bertazzoni U, Poli G, Casoli C Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. Blood, 2002-01-01;99(1):224-31. 2002-01-01 [PMID: 11756175] (Human)
• Black , K P, Merrill , K W, Jackson , S, Katz , J Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity. Oral Microbiol Immunol, 2000-04-01;15(2):74-81. 2000-04-01 [PMID: 11155169] (Human)
• Kadowaki N, Antonenko S, Lau JY, Liu YJ Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med., 2000-07-17;192(2):219-26. 2000-07-17 [PMID: 10899908] (Human)
• Petitto JM, Leserman J, Perkins DO, Stern RA, Silva SG, Gettes D, Zheng B, Folds JD, Golden RN, Evans DL High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status. Behav Med, 2000-01-01;25(4):143-51. 2000-01-01 [PMID: 10789020] (Human)
• Lankford KV, Mosunjac M, Hillyer CD Effects of UVB radiation on cytokine generation, cell adhesion molecules, and cell activation markers in T-lymphocytes and peripheral blood HPCs. Transfusion, 2000-03-01;40(3):361-7. 2000-03-01 [PMID: 10738040] (Human)
• Searle RF, Bromage SJ, Palmer J, Curry JE, Lang AK Human amniotic fluid lacks interleukin-2 and interleukin-15 but can interact with the beta-chain of the interleukin-2 receptor. Immunology, 2000-03-01;99(3):411-7. 2000-03-01 [PMID: 10712671] (Human)

Bioinformatics

• Gene Symbol: IL2