Human IL-6/IL-6R alpha Complex DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-6/IL-6R alpha Complex DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL6

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-6/IL-6R alpha Complex DuoSet ELISA, 5 Plate

• IL-6/IL-6R alpha Complex

Background

IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.

Publications for IL-6/IL-6R alpha Complex (DY8139-05)(4)

Publications using DY8139-05

• Somova, M;Simm, S;Ehrhardt, J;Schoon, J;Burchardt, M;Pinto, PC; SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma Cells 2024-12-10 [PMID: 39768130] (ELISA, Human)
• Chen, D;Lin, Y;Ko, P;Lin, J;Huang, C;Wang, G;Chang, KC; Effect of targeted temperature management on systemic inflammatory responses after out-of-hospital cardiac arrest: A prospective cohort study Medicine 2024-09-20 [PMID: 39312301] (Human)
• M Soutto, Z Chen, AA Bhat, L Wang, S Zhu, A Gomaa, A Bates, NS Bhat, D Peng, A Belkhiri, MB Piazuelo, MK Washington, XC Steven, R Peek, W El-Rifai Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia Nat Commun, 2019-07-10;10(1):3039. 2019-07-10 [PMID: 31292446] (Human)
• P Baran, S Hansen, GH Waetzig, M Akbarzadeh, L Lamertz, HJ Huber, MR Ahmadian, JM Moll, J Scheller The balance of�Interleukin (IL)-6, IL-6:soluble IL-6 receptor (IL-6R) and IL-6:sIL-6R:sgp130 complexes allows simultaneous classic and trans-signaling J. Biol. Chem., 2018-03-20;0(0):. 2018-03-20 [PMID: 29559558]

Bioinformatics

• Gene Symbol: IL6