Human TGF-beta 1 Quantikine ELISA Kit

Product Discontinued

Human TGF-beta 1 Quantikine ELISA Kit Summary

• Background: The Quantikine Human TGF-beta 1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TGF-beta 1 in acid activated cell culture supernates, serum, plasma, and urine. It contains recombinant human TGF-beta 1 expressed by CHO cells and has been shown to quantitate the recombinant factor accurately. Results obtained using natural TGF-beta 1 showed linear curves that were parallel to t...he standard curves obtained using the recombinant kit standards. These results indicate that this kit will provide accurate quantitation for both recombinant and natural human TGF-beta 1.
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• Additional Information: This product has been discontinued
• Specificity: Natural and recombinant TGF-beta 1. This kit cross-reacts 15% with human Latent TGF-beta 1 complex and also recognizes human TGF-beta 1.2 and mouse, rat, porcine, and canine TGF-beta 1.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TGFB1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TGF-beta 1 Quantikine ELISA Kit

• CEDLAP
• DPD1
• latency-associated peptide
• TGF beta
• TGF beta1
• TGFB
• TGFB1
• TGF-beta 1 protein
• TGFbeta 1
• TGF-beta 1
• TGFbeta
• TGF-beta-1
• transforming growth factor beta-1
• transforming growth factor, beta 1

Background

Human TGF-beta 1 is a 25 kDa, disulfide-linked homodimeric protein involved in a number of key developmental, immunologic, and homeostatic processes (1-4). The molecule is synthesized as a 390 amino acid (aa) precursor that contains a 23 aa signal sequence, a 255 aa pro-region, and a 112 aa mature segment. Processing of the molecule is complex, and it is generally secreted as a latent form (5). Prior to release, the prepro-form is cleaved of its signal sequence, followed by glycosylation of its pro-region. The glycosylation process includes the unusual attachment of mannose-6 phosphate residues. This is followed by furin convertase-mediated cleavage of the prohormone, creating an 80 kDa disulfide-linked proregion (termed LAP for latency-associated protein), plus a 25 kDa disulfidelinked mature segment (termed TGF-beta 1) (6-8). These two independent disulfide-linked polypeptides associate in a non-covalent interaction that renders TGF-beta 1 inactive. Although direct secretion of this 80K:25K complex can occur, it does so inefficiently. To facilitate secretion plus extracellular storage, a third 200 kDa component termed LTBP is covalently-linked to the N-terminus of one of the two LAP polypeptide chains. This promotes secretion and subsequent storage within the extracellular matrix (9, 10). After secretion, TGF-beta 1, via LTBP, covalently links to ECM. This complex is later cleaved by proteases and released, exposing mannose residues on LAP. It is postulated that exposed LAP mannose residues now are able to bind to cell surface IGF-II R, where dissociative events disrupt the LAP-TGF-beta 1 complex. This results in the release of active, homodimeric TGF-beta 1 (7, 10). Mature mouse TGF-beta 1 shares 100% aa sequence identity with rat and cotton rat TGF-beta 1 (11, 12), 99% aa identity with human, canine, and porcine TGF-beta 1 (13, 14, 15), and 97% aa identity with guinea pig TGF-beta 1 (16). Relative to mouse TGF-beta 2 and beta 3, mature mouse TGF-beta 1 shares 72% and 78% aa sequence identity, respectively (17, 18). 

The traditional high-affinity receptor for TGF-beta 1 is a heteromeric complex consisting of transmembrane serine/threonine kinases. Two types are involved; a constitutively phosphorylated, ligand-binding 80 kDa glycoprotein termed T beta RII and a signal-transducing, non-ligand-binding 55 kDa glycoprotein termed T beta RI/ALK-5 (19-22). It is suggested that TGF-beta 1first binds T beta RII, which then initiates a crossphosphorylation of T beta RI, culminating in signal transduction. There is also a third TGF-beta receptor termed T beta RIII, which can be either the 250 kDa proteoglycan named betaglycan, or the 180 kDa glycoprotein termed endoglin/CD105 (23, 24). It has been proposed that T beta RIII captures TGF-beta and "passes" it to T beta RII (20). This is perhaps true for betaglycan but not endoglin. Endoglin does not bind TGF-beta by itself; only within the context of T beta RII ligand binding. Evidence suggests that rather than "passing" on ligand, endoglin may actually enter the receptor complex and modulate TGF-beta downstream signaling (25, 26). Finally, and although ALK-5 has traditionally been assumed to be the only type I signaling receptor for TGF-beta 1, it is also possible that ALK-1 may serve as a condition-dependent, type I TGF-beta receptor (27). 

TGF-beta 1 has a wide range of activities. During an immune response, TGF-beta 1 impacts antibody production by preferentially induceing IgA production in both mouse and human (28). It also regulates dendritic cell chemotaxis by altering the expression of chemokine receptors (29). Finally, it can downmodulate an inflammatory response by dampening macrophage activity and proinflammatory secretion (30). During wound healing, TGF-beta 1 is released from activated platelets. This local source of TGF-beta 1 has marked stimulatory effects on fibroblasts, where it induces matrix synthesis; on monocytes, where it induces proinflammatory mediator and growth factor secretion; and on keratinocytes, where it may promote keratinocyte proliferation by downmodulating its own signaling pathway (31). Finally, during development, TGF-beta 1 may play a role in endochondral ossification, and its absence results in severely defective yolk sac vasculogenesis and hematopoiesis (32, 33). 

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TGF-beta 1 (DB100B)(418)

Publications using DB100B

• Iacovacci, J;Serafini, MS;Avuzzi, B;Badenchini, F;Cicchetti, A;Devecchi, A;Dispinzieri, M;Doldi, V;Giandini, T;Gioscio, E;Mancinelli, E;Noris Chiorda, B;Orlandi, E;Palorini, F;Possenti, L;Reis Ferreira, M;Villa, S;Zaffaroni, N;De Cecco, L;Valdagni, R;Rancati, T; Intestinal microbiota composition is predictive of radiotherapy-induced acute gastrointestinal toxicity in prostate cancer patients EBioMedicine 2024-07-18 [PMID: 39029427] (Human)
• Zahraeifard, S;Xiao, Z;So, JY;Ahad, A;Montoya, S;Park, WY;Sornapudi, T;Andohkow, T;Read, A;Kedei, N;Koparde, V;Yang, H;Lee, M;Wong, N;Cam, M;Wang, K;Ruppin, E;Luo, J;Hollander, C;Yang, L; Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression Nature communications 2024-07-12 [PMID: 38997291] (Mouse)
• Thangaraj, JL;Coffey, M;Lopez, E;Kaufman, DS; Disruption of TGF-? signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells Cell stem cell 2024-07-01 [PMID: 38986609] (Western Blot, Human)
• Kutuk, MO;Tufan, AE;Kilicaslan, F;Gokcen, C;Aksu, GG;Yektas, C;Kandemir, H;Celik, F;Mutluer, T;Buber, A;Karadag, M;Coban, N;Coskun, S;Hangul, Z;Altintas, E;Acikbas, U;Giray, A;Aka, Y;Basturk, B;Kutuk, O; Cytokine expression profiles in children and adolescents with tic disorders Scientific reports 2024-07-02 [PMID: 38956051] (Human)
• Amirkhosravi, A;Mirtajaddini Goki, M;Heidari, MR;Karami-Mohajeri, S;Iranpour, M;Torshabi, M;Mehrabani, M;Mandegary, A;Mehrabani, M; Combination of losartan with pirfenidone: a protective anti-fibrotic against pulmonary fibrosis induced by bleomycin in rats Scientific reports 2024-04-16 [PMID: 38622264] (Rat)
• Grasso, M;Fidilio, A;L'Episcopo, F;Recupero, M;Barone, C;Bacalini, MG;Benatti, C;Giambirtone, MC;Caruso, G;Greco, D;Di Nuovo, S;Romano, C;Ferri, R;Buono, S;Cuello, AC;Blom, JMC;Tascedda, F;Piazza, PV;De La Torre, R;Caraci, F; Low TGF-?1 plasma levels are associated with cognitive decline in Down syndrome Frontiers in pharmacology 2024-03-21 [PMID: 38576478] (Human)
• Yonemura, A;Semba, T;Zhang, J;Fan, Y;Yasuda-Yoshihara, N;Wang, H;Uchihara, T;Yasuda, T;Nishimura, A;Fu, L;Hu, X;Wei, F;Kitamura, F;Akiyama, T;Yamashita, K;Eto, K;Iwagami, S;Iwatsuki, M;Miyamoto, Y;Matsusaki, K;Yamasaki, J;Nagano, O;Saya, H;Song, S;Tan, P;Baba, H;Ajani, JA;Ishimoto, T; Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment Cell reports 2023-12-30 [PMID: 38232734] (Human)
• Miyahara, Y;Chen, H;Moriyama, M;Mochizuki, K;Kaneko, N;Haque, ASMR;Chinju, A;Kai, K;Sakamoto, M;Kakizoe-Ishiguro, N;Yamauchi, M;Ogata, K;Kiyoshima, T;Kawano, S;Nakamura, S; Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K Scientific reports 2023-11-07 [PMID: 37935734] (Human)
• Dasgupta, Q;Jiang, A;Wen, AM;Mannix, RJ;Man, Y;Hall, S;Javorsky, E;Ingber, DE; A human lung alveolus-on-a-chip model of acute radiation-induced lung injury Nature communications 2023-10-16 [PMID: 37845224] (Human)
• Krug, J;Bochenek, ML;Gogiraju, R;Laubert-Reh, D;Lackner, KJ;Münzel, T;Wild, PS;Espinola-Klein, C;Schäfer, K; Circulating Soluble EPCR Levels Are Reduced in Patients with Ischemic Peripheral Artery Disease and Associated with Markers of Endothelial and Vascular Function Biomedicines 2023-09-04 [PMID: 37760900] (Human)
• Aboussekhra, A;Alraouji, NN;Al-Mohanna, FH;Al-Khalaf, H; Ionizing radiation normalizes the features of active breast cancer stromal fibroblasts and suppresses their paracrine pro-carcinogenic effects Translational oncology 2023-09-04 [PMID: 37672859] (Human)
• Yu, Y;Fang, R;Jin, H;Wang, B;Gao, F;He, B; Correlation between Serum Myosin Light Chain 4 Levels and Recurrence after Radiofrequency Ablation in Patients with Atrial Fibrillation International heart journal 2023-07-30 [PMID: 37518344] (Human)
• Haake, M;Haack, B;Schäfer, T;Harter, PN;Mattavelli, G;Eiring, P;Vashist, N;Wedekink, F;Genssler, S;Fischer, B;Dahlhoff, J;Mokhtari, F;Kuzkina, A;Welters, MJP;Benz, TM;Sorger, L;Thiemann, V;Almanzar, G;Selle, M;Thein, K;Späth, J;Gonzalez, MC;Reitinger, C;Ipsen-Escobedo, A;Wistuba-Hamprecht, K;Eichler, K;Filipski, K;Zeiner, PS;Beschorner, R;Goedemans, R;Gogolla, FH;Hackl, H;Rooswinkel, RW;Thiem, A;Roche, PR;Joshi, H;Pühringer, D;Wöckel, A;Diessner, JE;Rüdiger, M;Leo, E;Cheng, PF;Levesque, MP;Goebeler, M;Sauer, M;Nimmerjahn, F;Schuberth-Wagner, C;von Felten, S;Mittelbronn, M;Mehling, M;Beilhack, A;van der Burg, SH;Riedel, A;Weide, B;Dummer, R;Wischhusen, J; Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment Nature communications 2023-07-20 [PMID: 37474523] (N/A)
• Amini, M;Venkatesan, JK;Nguyen, TN;Liu, W;Leroux, A;Madry, H;Migonney, V;Cucchiarini, M; rAAV TGF-beta and FGF-2 Overexpression via pNaSS-Grafted PCL Films Stimulates the Reparative Activities of Human ACL Fibroblasts International journal of molecular sciences 2023-07-06 [PMID: 37446318] (Human)
• Yang, YC;Chien, Y;Yarmishyn, AA;Lim, LY;Tsai, HY;Kuo, WC;Tsai, PH;Yang, SH;Hong, SI;Chen, SJ;Hwang, DK;Yang, YP;Chiou, SH; Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation Journal of advanced research 2023-06-14 [PMID: 37328058] (Human)
• Fukuda, K;Mita, H;Tamura, N;Kuroda, T;Kuwano, A;Takahashi, T;Sato, F; Characteristic inflammatory biomarkers in an equine model of persistent synovitis induced by the intra-articular administration of monoiodoacetic acid Journal of equine veterinary science 2023-05-18 [PMID: 37209789] (Equine)
• Buchheit, T;Huh, Y;Breglio, A;Bang, S;Xu, J;Matsuoka, Y;Guo, R;Bortsov, A;Reinecke, J;Wehling, P;Jun Huang, T;Ji, RR; Intrathecal Administration of Conditioned Serum from Different Species Resolves Chemotherapy-Induced Neuropathic Pain in Mice via Secretory Exosomes Brain, behavior, and immunity 2023-05-05 [PMID: 37150265] (Human)
• HW Yang, YH Sun, CY Fang, Y Ohiro, HY Liao, YW Liao, YH Kao, CC Yu Downregulation of histone deacetylase 8 (HDAC8) alleviated the progression of oral submucous fibrosis Journal of dental sciences, 2022-10-19;18(2):652-658. 2022-10-19 [PMID: 37021220] (Human)
• HW Yang, YH Sun, CY Fang, Y Ohiro, HY Liao, YW Liao, YH Kao, CC Yu Downregulation of histone deacetylase 8 (HDAC8) alleviated the progression of oral submucous fibrosis Journal of dental sciences, 2023;18(2):652-658. 2023 [PMID: 37021220] (Human)
• Y Zhao, Z Weng, X Zhou, Z Xu, B Cao, B Wang, J Li Mesenchymal stromal cells promote the drug resistance of gastrointestinal stromal tumors by activating the PI3K-AKT pathway via TGF-beta2 Journal of Translational Medicine, 2023-03-25;21(1):219. 2023-03-25 [PMID: 36966336] (Human)
• C Beck, NP Casey, I Persiconi, NN Moharrami, A Sike, Y Jin, JA Kyte Development of a TGFbeta-IL-2/15 Switch Receptor for Use in Adoptive Cell Therapy Biomedicines, 2023-02-04;11(2):. 2023-02-04 [PMID: 36830995] (Human)
• S Matsuda, A Revandkar, TD Dubash, A Ravi, BS Wittner, M Lin, R Morris, R Burr, H Guo, K Seeger, A Szabolcs, D Che, L Nieman, GA Getz, DT Ting, MS Lawrence, J Gainor, DA Haber, S Maheswaran TGF-beta in the microenvironment induces a physiologically occurring immune-suppressive senescent state Cell Reports, 2023-02-22;42(3):112129. 2023-02-22 [PMID: 36821441] (Human)
• Y Fujino, S Kanmura, Y Morinaga, I Kojima, N Maeda, A Tanaka, H Maeda, K Kumagai, F Sasaki, S Tanoue, A Ido Hepatocyte growth factor ameliorates dextran sodium sulfate?induced colitis in a mouse model by altering the phenotype of intestinal macrophages Molecular Medicine Reports, 2023-02-17;27(3):. 2023-02-17 [PMID: 36799161] (Mouse)
• EA Ross, LA Turner, H Donnelly, A Saeed, MP Tsimbouri, KV Burgess, G Blackburn, V Jayawarna, Y Xiao, MAG Oliva, J Willis, J Bansal, P Reynolds, JA Wells, J Mountford, M Vassalli, N Gadegaard, ROC Oreffo, M Salmeron-S, MJ Dalby Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells Nature Communications, 2023-02-10;14(1):753. 2023-02-10 [PMID: 36765065] (Human)
• L Tanner, AB Single, RKV Bhongir, M Heusel, T Mohanty, CAQ Karlsson, L Pan, CM Clausson, J Bergwik, K Wang, CK Andersson, RM Oommen, JS Erjefält, J Malmström, O Wallner, I Boldogh, T Helleday, C Kalderén, A Egesten Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model Nature Communications, 2023-02-06;14(1):643. 2023-02-06 [PMID: 36746968] (Mouse)
• H Li, Y Jiang, J Hu, J Xu, L Chen, G Zhang, J Zhao, S Zong, Z Guo, X Li, X Zhao, Z Jing The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway Cell Death & Disease, 2023-01-13;14(1):23. 2023-01-13 [PMID: 36635261] (Human)
• I Soveral, L Guirado, MC Escobar-Di, MJ Alcaide, JM Martínez, V Rodríguez-, B Bijnens, E Antolin, E Llurba, JL Bartha, O Gómez, F Crispi Cord Blood Cardiovascular Biomarkers in Left-Sided Congenital Heart Disease Journal of Clinical Medicine, 2022-11-30;11(23):. 2022-11-30 [PMID: 36498692] (Human)
• C Cui, D Zhang, K Sun, Y Zhu, J Xu, Y Kang, G Zhang, Y Cai, S Mao, R Long, J Ma, S Dong, Y Sun Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor BMC immunology, 2022-11-25;23(1):58. 2022-11-25 [PMID: 36434505] (Human)
• AH Kadam, K Kandasamy, T Buss, B Cederstrom, C Yang, S Narayanapi, J Rodriguez, MD Levin, J Koziol, B Olenyuk, Z Borok, A Chrastina, JE Schnitzer Targeting caveolae to pump bispecific antibody to TGF-beta into diseased lungs enables ultra-low dose therapeutic efficacy PLoS ONE, 2022-11-22;17(11):e0276462. 2022-11-22 [PMID: 36413536] (Rat)
• K Kop?ali?, IZ Mati?, I Besu, V Stankovi?, Z Bukumiri?, TP Stanojkovi, A Stepanovi?, M Nikitovi? Circulating levels of IL-6 and TGF-beta1 in patients with prostate cancer undergoing radiotherapy: associations with acute radiotoxicity and fatigue symptoms BMC Cancer, 2022-11-11;22(1):1167. 2022-11-11 [PMID: 36368974] (Human)
• AD Ruggiero, R Vemuri, M Block, D DeStephani, M Davis, J Chou, A Williams, A Brock, SK Das, K Kavanagh Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity International Journal of Molecular Sciences, 2022-10-21;23(20):. 2022-10-21 [PMID: 36293536] (Primate - Chlorocebus aethiops (African Green Monkey))
• K Tange, S Yagi, E Takeshita, M Abe, Y Yamamoto, H Tomida, T Kawamura, M Hanayama, B Matsuura, Y Ikeda, Y Hiasa Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model Scientific Reports, 2022-10-26;12(1):17983. 2022-10-26 [PMID: 36289244] (Mouse)
• RM Critelli, F Milosa, A Romanzi, S Lasagni, G Marcelli, L Di Marco, A Pivetti, F Schepis, D Romagnoli, S Mancarella, F Dituri, ML Martinez-C, G Giannelli, E Villa Upregulation of the oestrogen target gene SIX1 is associated with higher growth speed and decreased survival in HCV-positive women with hepatocellular carcinoma Oncology Letters, 2022-09-21;24(5):395. 2022-09-21 [PMID: 36276500] (Human)
• Y Zhao, GCW Man, R Zhang, CK Wong, X Chen, JP Chung, CC Wang, S Laird, T Zhang, TC Li A prospective study comparing the inflammation-related cytokine and chemokine profile from the day of blastocyst transfer to 7 weeks of gestation between pregnancies that did or did not result in a miscarriage Journal of reproductive immunology, 2022-10-12;154(0):103755. 2022-10-12 [PMID: 36272272] (Human)
• S Piñeiro-He, P Martínez, G Bosso, JM Flores, S Saraswati, J Connor, R Lemaire, MA Blasco Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development Nature Communications, 2022-10-06;13(1):5656. 2022-10-06 [PMID: 36202783] (Mouse)
• Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Human)
• S Ortega-Peñ, M Chopin-Dor, A Tejeda-Fer, DM Giraldo-Gó, RM Salgado, E Krötzsch Dialkyl Carbamoyl Chloride-Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay Microorganisms, 2022-09-13;10(9):. 2022-09-13 [PMID: 36144427] (Mouse)
• J Trink, R Li, E Squire, K O'Neil, P Zheng, B Gao, JC Krepinsky Integrin beta1/Cell Surface GRP78 Complex Regulates TGFbeta1 and Its Profibrotic Effects in Response to High Glucose Biomedicines, 2022-09-10;10(9):. 2022-09-10 [PMID: 36140347] (Transgenic Mouse)
• Z Wu, X Bai, Z Lu, S Liu, H Jiang LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination Journal of Immunology Research, 2022-09-09;2022(0):6450721. 2022-09-09 [PMID: 36118415] (Human)
• KI Matsumoto, K Kawakami, K Yamada, H Takeshita COL1A1 expression induced by overexpression of both a 15?amino acid peptide from the fibrinogen domain of tenascin?X and integrin alpha11 in LX?2 cells Molecular Medicine Reports, 2022-09-07;26(5):. 2022-09-07 [PMID: 36069233] (Human)
• L Krakowski, M Wieszczecz, J Furmaga, I Krakowska, G Opielak, P Brodzki, T Piech, M Grodzka, D Domaga?a, O Furmaga, C Rokos Assessment of the possibility of using biomarkers (CCL11 and TGF-beta 1) in the diagnosis of prostate gland hyperplasia in dogs Theriogenology, 2022-08-10;192(0):9-13. 2022-08-10 [PMID: 36030614] (Canine)
• N Hirata, M Kiuchi, K Pak, R Fukuda, N Mochimaru, M Mitsui, K Yoshida Association between Maternal Characteristics and Immune Factors TGF-beta1, TGF-beta2, and IgA in Colostrum: An Exploratory Study in Japan Nutrients, 2022-08-09;14(16):. 2022-08-09 [PMID: 36014760] (Human)
• C Hawlitsche, J Brendel, P Gabriel, K Schierle, A Salameh, HG Zimmer, B Rassler How Effective Is a Late-Onset Antihypertensive Treatment? Studies with Captopril as Monotherapy and in Combination with Nifedipine in Old Spontaneously Hypertensive Rats Biomedicines, 2022-08-12;10(8):. 2022-08-12 [PMID: 36009511] (Rat)
• Y Wang, Y Li, Z Chen, Y Yuan, Q Su, K Ye, C Chen, G Li, Y Song, H Chen, Y Xu GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy Cell Death & Disease, 2022-08-08;13(8):693. 2022-08-08 [PMID: 35941120] (Mouse)
• W Feng, XQ Zhong, XX Zheng, QP Liu, MY Liu, XB Liu, CS Lin, Q Xu Study on the effect and mechanism of quercetin in treating gout arthritis International immunopharmacology, 2022-08-03;111(0):109112. 2022-08-03 [PMID: 35932610] (Rat)
• W Singhatana, S Kitpakorns, M Toso, P Pavasant IFNgamma-primed periodontal ligament cells regulate T-cell responses via IFNgamma-inducible mediators and ICAM-1-mediated direct cell contact Royal Society open science, 2022-07-27;9(7):220056. 2022-07-27 [PMID: 35911203] (Human)
• AM Soileau, CN Quick, CE Moeller, JC Schaumburg, SS Withers The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages Oncogene, 2022-07-21;9(7):. 2022-07-21 [PMID: 35878391] (Canine)
• S Pradhan, Snehlata, D Manna, S Karmakar, MK Singh, A Bhattachar, B Mukherjee, J Paul Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids Heliyon, 2022-07-03;8(7):e09868. 2022-07-03 [PMID: 35847617] (Mouse)
• AC Fears, BJ Beddingfie, NR Chirichell, N Slisarenko, SZ Killeen, RK Redmann, K Goff, S Spencer, B Picou, N Golden, CC Midkiff, DJ Bush, LM Branco, ML Boisen, H Gao, DC Montefiori, RV Blair, LA Doyle-Meye, K Russell-Lo, NJ Maness, CJ Roy Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species PloS Pathogens, 2022-07-05;18(7):e1010618. 2022-07-05 [PMID: 35789343] (Human)
• S Biswas Shi, Q Lu, D Sun, H Hou, JN Bulmer, BA Innes, DK Hapangama, GE Lash Platelet-derived growth factor BB is reduced in endometrial endothelial cells of women with abnormal uterine bleeding-endometrial disorder Oncogene, 2022-02-13;0(0):. 2022-02-13 [PMID: 35739007] (Human)
• A Gidaro, R Manetti, AP Delitala, MJ Soloski, G Lamberteng, D Castro, D Soldini, R Castelli Incidence of Venous Thromboembolism in Multiple Myeloma Patients across Different Regimens: Role of Procoagulant Microparticles and Cytokine Release Journal of Clinical Medicine, 2022-05-11;11(10):. 2022-05-11 [PMID: 35628848] (Human)
• B Wang, X Wang, L Yu, W Liu, J Song, L Fan, M Zhou, M Yang, J Ma, M Cheng, W Qiu, R Liang, D Wang, Y Guo, W Chen Acrylamide exposure increases cardiovascular risk of general adult population probably by inducing oxidative stress, inflammation, and TGF-beta1: A prospective cohort study Environment international, 2022-04-25;164(0):107261. 2022-04-25 [PMID: 35486963] (Human)
• J Štšepetova, K Simre, A Tagoma, O Uibo, A Peet, H Siljander, V Tillmann, M Knip, R Mändar, R Uibo Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring Scientific Reports, 2022-04-22;12(1):6607. 2022-04-22 [PMID: 35459889] (Human)
• K Chen, H Obara, Y Matsubara, K Fukuda, H Yagi, Y Ono-Uruga, K Matsubara, Y Kitagawa Adipose-Derived Mesenchymal Stromal/Stem Cell Line Prevents Hepatic Ischemia/Reperfusion Injury in Rats by Inhibiting Inflammasome Activation Cell Transplantation, 2022-01-01;31(0):9636897221089. 2022-01-01 [PMID: 35438583] (Rat)
• X García-Del, I Durán, JL Perez-Grac, M Ángel Clim, B Mellado, JA Virizuela, DE Castellano, A González D, I García Car, C Álvarez-Fe, J García-Don, M Gil-Martin, AG Hernández Molecular Biomarkers of Prognosis in Advanced Renal Cell Carcinoma Patients Treated With Pazopanib Plus Interferon Alpha (INF-2A) in a Phase I/II Study by the Spanish Oncology Genitourinary Group Clinical genitourinary cancer, 2022-03-18;0(0):. 2022-03-18 [PMID: 35428584] (Human)
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• Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J. Immunol., 2004-10-01;173(7):4433-42. 2004-10-01 [PMID: 15383574] (Human)
• Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Yoo J, Flanders KC, Roberts AB Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice. Lab. Invest., 2004-10-01;84(10):1245-58. 2004-10-01 [PMID: 15273699] (Human)
• Flores L, Näf S, Hernaez R, Conget I, Gomis R, Esmatjes E Transforming growth factor beta at clinical onset of Type 1 diabetes mellitus. A pilot study. Diabet. Med., 2004-08-01;21(8):818-22. 2004-08-01 [PMID: 15270783] (Human)
• Chen LL, Tager IB, Peden DB, Christian DL, Ferrando RE, Welch BS, Balmes JR Effect of ozone exposure on airway responses to inhaled allergen in asthmatic subjects. Chest, 2004-06-01;125(6):2328-35. 2004-06-01 [PMID: 15189958] (Human)
• Waldow T, Alexiou K, Witt W, Wagner FM, Gulielmos V, Matschke K, Knaut M Attenuation of reperfusion-induced systemic inflammation by preconditioning with nitric oxide in an in situ porcine model of normothermic lung ischemia. Chest, 2004-06-01;125(6):2253-9. 2004-06-01 [PMID: 15189949] (Porcine)
• Ogawa J, Sasahara A, Yoshida T, Sira MM, Futatani T, Kanegane H, Miyawaki T Role of transforming growth factor-beta in breast milk for initiation of IgA production in newborn infants. Early Hum. Dev., 2004-04-01;77(1):67-75. 2004-04-01 [PMID: 15113633] (Human)
• Branski RC, Rosen CA, Verdolini K, Hebda PA Markers of wound healing in vocal fold secretions from patients with laryngeal pathology. Ann. Otol. Rhinol. Laryngol., 2004-01-01;113(1):23-9. 2004-01-01 [PMID: 14763567] (Human)
• Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries. J. Androl., 2004-03-01;25(2):250-4. 2004-03-01 [PMID: 14760011] (Human)
• Soga Y, Takai S, Koyama T, Okamoto Y, Ikeda T, Nishimura K, Miyazaki M, Komeda M Attenuation of adhesion formation after cardiac surgery with a chymase inhibitor in a hamster model. J. Thorac. Cardiovasc. Surg., 2004-01-01;127(1):72-8. 2004-01-01 [PMID: 14752415] (Hamster)
• Chaiyaroj SC, Rutta AS, Muenthaisong K, Watkins P, Na Ubol M, Looareesuwan S Reduced levels of transforming growth factor-beta1, interleukin-12 and increased migration inhibitory factor are associated with severe malaria. Acta Trop., 2004-02-01;89(3):319-27. 2004-02-01 [PMID: 14744558] (Human)
• Verdolini K, Rosen CA, Branski RC, Hebda PA Shifts in biochemical markers associated with wound healing in laryngeal secretions following phonotrauma: a preliminary study. Ann. Otol. Rhinol. Laryngol., 2003-12-01;112(12):1021-5. 2003-12-01 [PMID: 14703104] (Human)
• Blanaru JL, Kohut JR, Fitzpatrick-Wong SC, Weiler HA Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula. Am. J. Clin. Nutr., 2004-01-01;79(1):139-47. 2004-01-01 [PMID: 14684410] (Porcine)
• Chen YJ, Kuo YR, Yang KD, Wang CJ, Huang HC, Wang FS Shock wave application enhances pertussis toxin protein-sensitive bone formation of segmental femoral defect in rats. J. Bone Miner. Res., 2003-12-01;18(12):2169-79. 2003-12-01 [PMID: 14672352] (Rat)
• Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright AL TGF-beta in human milk is associated with wheeze in infancy. J. Allergy Clin. Immunol., 2003-10-01;112(4):723-8. 2003-10-01 [PMID: 14564350] (Human)
• Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Mouse)
• Ewbank PA, Murray J, Sanders K, Curran-Everett D, Dreskin S, Nelson HS A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract. J. Allergy Clin. Immunol., 2003-01-01;111(1):155-61. 2003-01-01 [PMID: 12532112] (Human)
• Yekebas EF, Strate T, Zolmajd S, Eisenberger CF, Erbersdobler A, Saalmuller A, Steffani K, Busch C, Elsner HA, Engelhardt M, Gillesen A, Meins J, The M, Knoefel WT, Izbicki JR Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitis. Kidney Int., 2002-11-01;62(5):1806-18. 2002-11-01 [PMID: 12371983] (Porcine)
• Oshima Y, Sakamoto T, Hisatomi T, Tsutsumi C, Ueno H, Ishibashi T Gene transfer of soluble TGF-beta type II receptor inhibits experimental proliferative vitreoretinopathy. Gene Ther., 2002-09-01;9(18):1214-20. 2002-09-01 [PMID: 12215888] (Rabbit)
• Bracamonte MP, Rud KS, Owen WG, Miller VM Ovariectomy increases mitogens and platelet-induced proliferation of arterial smooth muscle. Am. J. Physiol. Heart Circ. Physiol., 2002-09-01;283(3):H853-60. 2002-09-01 [PMID: 12181111] (Porcine)
• D'Ovidio F Recipient intramuscular cotransfection of naked plasmid transforming growth factor beta1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg., 2002-08-01;124(2):259-69. 2002-08-01 [PMID: 12167785] (Rat)
• Luo XH, Liao EY, Su X Progesterone upregulates TGF-b isoforms (b1, b2, and b3) expression in normal human osteoblast-like cells. Calcif. Tissue Int., 2002-08-06;71(4):329-34. 2002-08-06 [PMID: 12154395] (Human)
• Benson M, 2019, Carlsson B, Carlsson LM, Mostad P, Svensson PA, Cardell LO DNA microarray analysis of transforming growth factor-beta and related transcripts in nasal biopsies from patients with allergic rhinitis. e0208677, 2002-04-07;18(1):20-5. 2002-04-07 [PMID: 12090756] (Human)
• Truckenmiller ME, Vawter MP, Zhang P, Conejero-Goldberg C, Dillon-Carter O, Morales N, Cheadle C, Becker KG, Freed WJ AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression. Exp. Neurol., 2002-06-01;175(0):318. 2002-06-01 [PMID: 12061863] (Rat)
• Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta. 101211, 2002-03-01;81(3):138-44. 2002-03-01 [PMID: 11998865] (Bovine)
• Lee JB, 2019, Choe CM, Kim HS, Seo KY, Seong GJ, Kim EK Comparison of TGF-beta1 in tears following laser subepithelial keratomileusis and photorefractive keratectomy. 6907, 2002-03-01;18(2):130-4. 2002-03-01 [PMID: 11934200] (Human)
• Agarwal R, Siva S, Dunn SR, Sharma K Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels. Am. J. Kidney Dis., 2002-03-01;39(3):486-92. 2002-03-01 [PMID: 11877567] (Human)
• Wei H, Loimaranta V, Tenovuo J, Rokka S, Syvaoja EL, Korhonen H, Joutsjoki V, Marnila P Stability and activity of specific antibodies against Streptococcus mutans and Streptococcus sobrinus in bovine milk fermented with Lactobacillus rhamnosus strain GG or treated at ultra-high temperature. Oral Microbiol. Immunol., 2002-02-01;17(1):9-15. 2002-02-01 [PMID: 11860550] (Bovine)
• Skutek M, van Griensven M, Zeichen J, Brauer N, Bosch U Cyclic mechanical stretching modulates secretion pattern of growth factors in human tendon fibroblasts. Eur. J. Appl. Physiol., 2001-11-01;86(1):48-52. 2001-11-01 [PMID: 11820322] (Human)
• Liu BY, 2019, Wu PW, Bringhurst FR, Wang JT Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC. 141-147, 2002-02-01;143(2):627-35. 2002-02-01 [PMID: 11796519] (Mouse)
• Margetts PJ, Kolb M, Galt T, Hoff CM, Shockley TR, Gauldie J Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J. Am. Soc. Nephrol., 2001-10-01;12(10):2029-39. 2001-10-01 [PMID: 11562401] (Rat)
• Otterness IG, Swindell AC, Zimmerer RO, Poole AR, Ionescu M, Weiner E An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline. Osteoarthr. Cartil., 2000-05-01;8(3):180-5. 2000-05-01 [PMID: 10806045] (Human)
• Landesberg R, Roy M, Glickman RS Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation. J. Oral Maxillofac. Surg., 2000-03-01;58(3):297. 2000-03-01 [PMID: 10716112] (Human)
• Kalliomaki M, Ouwehand A, Arvilommi H, Kero P, Isolauri E Transforming growth factor-beta in breast milk: a potential regulator of atopic disease at an early age. J. Allergy Clin. Immunol., 1999-12-01;104(6):1251-7. 1999-12-01 [PMID: 10589009] (Human)
• Soubrier M, Sauron C, Souweine B, Larroche C, Wechsler B, Guillevin L, Piette JC, Rousset H, Deteix P Growth factors and proinflammatory cytokines in the renal involvement of POEMS syndrome. Am. J. Kidney Dis., 1999-10-01;34(4):633-8. 1999-10-01 [PMID: 10516342] (Human)
• Fadok , V A, Bratton , D L, Konowal , A, Freed , P W, Westcott , J Y, Henson , P M Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest, 1998-02-15;101(4):890-8. 1998-02-15 [PMID: 9466984] (Human)
• Groux , H, O'Garra , A, Bigler , M, Rouleau , M, Antonenko , S, de Vries , J E, Roncarolo , M G A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature, 1997-10-16;389(6652):737-42. 1997-10-16 [PMID: 9338786] (Human)
• Gu JW, Adair TH Hypoxia-induced expression of VEGF is reversible in myocardial vascular smooth muscle cells. Am. J. Physiol., 1997-08-01;273(2):H628-33. 1997-08-01 [PMID: 9277477] (Canine)
• Chopra V, Dinh TV, Hannigan EV Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer. J. Cancer Res. Clin. Oncol., 1997-01-01;123(3):167-72. 1997-01-01 [PMID: 9119882] (Human)

Bioinformatics

• Gene Symbol: TGFB1