IFN-alpha/beta R2 Antibody

Immunohistochemistry-Paraffin: IFN-alpha/beta R2 Antibody [NBP1-20934] - (5ug/ml) staining of Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Flow Cytometry: IFN-alpha/beta R2 Antibody [NBP1-20934] - Flow cytometric analysis of paraformaldehyde fixed K562 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.

Immunohistochemistry-Paraffin: IFN-alpha/beta R2 Antibody [NBP1-20934] - (5ug/ml) staining of Human Prostate. Steamed antigen retrieval with citrate buffer Ph 6, AP-staining.

• Reactivity: Hu
• Applications: WB, ELISA, Flow, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

IFN-alpha/beta R2 Antibody Summary

• Immunogen: Peptide with sequence SYDSPDYTDESCT corresponding to internal region according to NP_000865.2 , NP_997467.1, NP_997468.1 .
• Epitope: internal region
• Specificity: This antibody is expected to recognise all three reported isoforms (NP_000865.2 ; NP_997467.1; NP_997468.1 )
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IFNAR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/mL
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 0.2 ug/mL

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for IFN-alpha/beta R2 Antibody

• beta receptor10
• human interferon alpha
• human interferon alpha/beta receptor
• IFNABR
• IFN-alpha binding protein
• IFN-alpha/beta R2
• IFN-alpha/beta receptor 2
• IFN-alpha-REC
• IFNAR2
• IFN-aR2
• IFNARB
• IFNbR2
• IFN-bR2
• IFN-R
• IFN-R-2
• interferon (alpha, beta and omega) receptor 2
• Interferon alpha binding protein
• interferon alpha/beta receptor 2
• interferon-alpha/beta receptor beta chain
• Type I interferon receptor 2

Background

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-alpha/beta R2 Antibody (NBP1-20934)(1)

Publication using NBP1-20934

• Keller BC, Fredericksen BL, Samuel MA et al. Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J Virol 2006-10-01 [PMID: 16973548]

Bioinformatics

• Gene Symbol: IFNAR2
• Entrez:
  • 3455(Human)
• Uniprot:
  • NP_000865.2(Human)