Integrin alpha 3/CD49c Antibody [Phycoerythrin]

C2C12 mouse myoblast cell line was stained with Goat Anti-Mouse Integrin a3/CD49c PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB2787P, filled histogram) or isotype control antibody (IC108P, open histogram). Staining was performed using our Staining Membrane-associated Proteins protocol.

XB2 mouse teratoma keratinocyte cell line was stained with Goat Anti-Mouse Integrin a3/CD49c PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB2787P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Mu
• Applications: Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Phycoerythrin

Integrin alpha 3/CD49c Antibody [Phycoerythrin] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Integrin alpha 3/CD49c
  Phe33-Glu993
  Accession # Q62470
• Specificity: Detects mouse Integrin alpha 3/CD49c in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse (rm) Integrin alpha 2, rmIntegrin alpha 4, rmIntegrin alpha 5, rmIntegrin alpha E, rmIntegrin alpha M, rmIntegrin alpha V and rmIntegrin alpha X is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ITGA3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha 3/CD49c Antibody [Phycoerythrin]

• antigen identified by monoclonal J143
• CD49 antigen-like family member C
• CD49c antigen
• CD49c
• FLJ34631
• FLJ34704
• FRP-2
• Galactoprotein B3
• GAP-B3
• GAPB3CD49C
• Integrin alpha 3
• integrin alpha-3
• integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
• ITGA3
• MSK18
• VCA-2
• very late activation protein 3 receptor, alpha-3 subunit
• VL3A
• VLA-3 subunit alpha
• VLA3a

Background

Integrin alpha 3, also known as CD49c and VLA-3 alpha , is a type I membrane protein that heterodimerizes with Integrin beta 1. alpha 3 beta 1 is a cell surface adhesion molecule that functions as a receptor for Laminin, Fibronectin, Collagen, Epiligrin, Thrombospondin and Chondroitin Sulfate Proteoglycan 4. The extracellular domain of human and mouse Integrin alpha 3 share approximately 87% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 3/CD49c Antibody (FAB2787P)(2)

Publications using FAB2787P

• Elloumi-Hannachi I, Garcia J, Shekeran A, Garcia A Contributions of the integrin beta1 tail to cell adhesive forces. Exp Cell Res, 2014-11-25;332(2):212-22. 2014-11-25 [PMID: 25460334] (Flow Cytometry, Mouse)
• Sprague L, Muccioli M, Pate M, Singh M, Xiong C, Ostermann A, Niese B, Li Y, Li Y, Courreges M, Benencia F Dendritic cells: In vitro culture in two- and three-dimensional collagen systems and expression of collagen receptors in tumors and atherosclerotic microenvironments. Exp Cell Res, 2014-02-22;323(1):7-27. 2014-02-22 [PMID: 24569142] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: ITGA3
• Uniprot:
  • Q62470()