Lipoprotein Lipase/LPL Antibody (JA22-02)

Western Blot: Lipoprotein Lipase/LPL Antibody (JA22-02) [NBP2-66936] - Analysis of Lipoprotein lipase on human placenta tissue lysate using anti-Lipoprotein lipase antibody at 1/1,000 dilution.

Immunohistochemistry-Paraffin: Lipoprotein Lipase/LPL Antibody (JA22-02) [NBP2-66936] - Analysis of paraffin-embedded human pancreas tissue using anti-Lipoprotein lipase antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: Lipoprotein Lipase/LPL Antibody (JA22-02) [NBP2-66936] - Analysis of paraffin-embedded human ileum tissue using anti-Lipoprotein lipase antibody. Counter stained with hematoxylin.

Product Discontinued

Lipoprotein Lipase/LPL Antibody (JA22-02) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic peptide within Human Lipoprotein Lipase/LPL aa 456-475 / 475. (SwissProt: P06858 Human)
• Localization: Cell membrane. Secreted.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: LPL
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Lipoprotein Lipase/LPL Antibody (JA22-02)

• EC 3.1.1
• HDLCQ11
• LIPD
• LIPDEC 3.1.1.34
• Lipoprotein Lipase
• LPL

Background

LPL, also known as Lipoprotein lipase, is a 475 amino acid that is 53 kDa, is a vascular lipase, but not synthesized in endothelial cells. It is anchored to the capillary endothelium by proteoglycans and acts as a catalyzer of triglycerides hydrolysis to release free fatty acids into the circulation and initiates the processing of triglyceride-rich lipoproteins such as chylomicrons and VLDL. It is being studied for its involvement in 150+ diseases and disorders including high density lipoprotein cholesterol level qtl 11, hyperlipoproteinemia, lipoprotein lipase deficiency, familial lipoprotein lipase deficiency, hyperlipoproteinemia type v, lipase deficiency combined, hyperlipoproteinemia type iii, glycogen storage disease, hyperlipidemia, hypertriglyceridemia, glucose intolerance, cetp deficiency, hypertension, fatty liver, nephrotic syndrome, kidney failure, and myocardial infarction. This protein has been shown to interact with 50 proteins including COPS6, PTPN4, RPL18A, ASCC2, KIAA1377 in developmental biology, transcriptional regulation of white adipocyte differentiation, lipid digestion, mobilization, and transport, metabolism, lipoprotein metabolism, glycerolipid metabolism, PPAR signaling pathway, and Alzheimer's disease pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LPL