LRG1 Antibody (2F5.A2)

• Reactivity: Hu
• Applications: ELISA
• Clone: 2F5.A2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.1 mg/ml

LRG1 Antibody (2F5.A2) Summary

• Immunogen: Human LRG, covalently coupled to hemocyanin using glutaraldehyde
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: LRG1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoassay 1 ug/ml
• Application Notes: Antibody was used as detector for LRG on cytochrome C coated plates.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS, containing 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A or G purified

Alternate Names for LRG1 Antibody (2F5.A2)

• 1300008B03Rik
• 2310031E04Rik
• HMFT1766
• leucine-rich alpha-2-glycoprotein 1
• leucine-rich alpha-2-glycoprotein
• LRG1
• LRGleucine rich alpha 2 glycoprotein

Background

The monoclonal antibody recognizes leucine-rich alpha-2-glycoprotein (LRG), a member of the leucine-rich repeat family. LRG is a plasma protein of approximately 50 kDa. LRG consists of 312 amino acids. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312 amino acids, and LRG contains at least eight 24-amino acid leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells. The monoclonal antibody 2F5.A2 can be used for immuno purification of human LRG.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LRG1 Antibody (NBP1-51830)(2)

Publications using NBP1-51830

• Codina R, Vanasse A, Kelekar A et al. Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1. Apoptosis. 2010-02-01 [PMID: 19851871]
• Weivoda S, Andersen JD, Skogen A et al. ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand. J Immunol Methods. 2008-07-01 [PMID: 18436231]

Bioinformatics

• Gene Symbol: LRG1
• Entrez:
  • 116844(Human)
• Uniprot:
  • P02750()