LXR alpha/NR1H3 Antibody (PPZ0412) - Ligand Binding Domain

• Reactivity: Hu
• Applications: WB, IHC, IP, GS
• Clone: PPZ0412
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

LXR alpha/NR1H3 Antibody (PPZ0412) - Ligand Binding Domain Summary

• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: NR1H3

Applications/Dilutions

• Dilutions:
  • Gel Supershift Assay
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Buffer: A liquid formulation in physiologic saline with 0.1% NaN₃.
• Preservative: 0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LXR alpha/NR1H3 Antibody (PPZ0412) - Ligand Binding Domain

• alpha
• Liver X receptor alpha
• liver X receptor-alpha
• LXR alpha
• LXRA
• NR1H3
• Nuclear receptor subfamily 1 group H member 3
• nuclear receptor subfamily 1, group H, member 3
• oxysterols receptor LXR-alpha
• RLD-1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LXR alpha/NR1H3 Antibody (PP-PPZ0412-00)(10)

Publications using PP-PPZ0412-00

• Korenfeld, N;Gorbonos, T;Romero Florian, MC;Rotaro, D;Goldberg, D;Radushkevitz-Frishman, T;Charni-Natan, M;Bar-Shimon, M;Cummins, CL;Goldstein, I; LXR-dependent enhancer activation regulates the temporal organization of the liver's response to refeeding leading to lipogenic gene overshoot PLoS biology 2024-09-01 [PMID: 39241209] (Chromatin Immunoprecipitation (ChIP), Mouse, Transgenic Mouse)
• Priscilia Lianto, Samantha A. Hutchinson, J. Bernadette Moore, Thomas A. Hughes, James L. Thorne Characterization and prognostic value of LXR splice variants in triple-negative breast cancer iScience 2021-10-22 [PMID: 34755086]
• Kain J, Wei X, Reddy Na Et Al. Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXR alpha Molecular metabolism 2021-07-08 [PMID: 34246806]
• Samantha A. Hutchinson, Alex Websdale, Giorgia Cioccoloni, Hanne Røberg-Larsen, Priscilia Lianto, Baek Kim et al. Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer Oncogene 2021-04-22 [PMID: 33742124]
• Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian et al. 4 beta -Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor Journal of Lipid Research 2021-02-23 [PMID: 33631213]
• Fan Q, Norgaard RC, Grytten I et al. LXR alpha Regulates ChREBP alpha Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction Cells 2020-05-13 [PMID: 32414201]
• Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel et al. Inflammation Triggers Liver X Receptor-Dependent Lipogenesis Molecular and Cellular Biology 2020-01-03 [PMID: 31658997]
• S Della Torr, N Mitro, R Fontana, M Gomaraschi, E Favari, C Recordati, F Lolli, F Quagliarin, C Meda, C Ohlsson, M Crestani, NH Uhlenhaut, L Calabresi, A Maggi An Essential Role for Liver ER? in Coupling Hepatic Metabolism to the Reproductive Cycle Cell Rep, 2016-03-31;15(2):360-71. 2016-03-31 [PMID: 27050513] (ChIP, Mouse)
• Torocsik D, Barath M, Benko S, Szeles L, Dezso B, Poliska S, Hegyi Z, Homolya L, Szatmari I, Lanyi A, Nagy L Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli. J. Immunol., 2010-04-21;184(10):5456-65. 2010-04-21 [PMID: 20410489] (IHC-P, Western Blot, Human)
• Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. J. Immunol., 2008-03-01;180(5):3305-12. 2008-03-01 [PMID: 18292555] (IHC-P, Mouse)

Bioinformatics

• Gene Symbol: NR1H3