mGluR4 Antibody

Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS909] - Brain, cortex neurons

Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS909] - Analysis of anti-GRM4 / MGLUR4 antibody with human brain, neurons and glia.

Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS909] - Analysis of anti-GRM4 / MGLUR4 antibody with human brain, glioblastoma.

Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS909] - Human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS909] - Brain, Substantia nigra white matter

Product Discontinued

mGluR4 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM4 / MGLUR4.
• Localization: Membrane; multi pass membrane protein.
• Specificity: Human GRM4 / MGLUR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRM4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Chimpanzee, Gorilla. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Opossum (84%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for mGluR4 Antibody

• glutamate receptor, metabotropic 4
• GPRC1D
• GPRC1Dmetabotropic glutamate receptor 4
• GRM4
• MGC177594
• mGlu4
• mGluR4
• MGLUR4glutamate metabotropic receptor 4

Background

The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors that are linked to the inhibition of the cyclic AMP signaling cascade. Two protein isoforms have been reported in rat (mGluR4a 912 aa; mGluRb 983 aa), which differ at the C-terminus. GRM4 has been reported in various regions of the brain, eye, and spinal cord. ESTs have been isolated from brain, embryo, melanocyte/uterus/fetal heart, nerve, and testis libraries. Caution: GLUR4 refers to Ionotropic Glutamate Receptor 4, not to Metabotropic Glutamate Receptor 4 (mGLUR4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRM4
• Entrez:
  • 2914(Human)
• Uniprot:
  • Q14833(Human)