Mouse PlGF-2 Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse PlGF-2 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse PlGF-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse PlGF-2 levels in cell culture supernates, serum, and plasma. It contains Sf 21-expressed recombinant mouse PlGF-2 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse P...lGF-2 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse PlGF-2.
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• Specificity: Natural and recombinant mouse PlGF-2
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Pgf

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse PlGF-2 Quantikine ELISA Kit

• OORS
• PlGF2
• PlGF-2

Background

Placenta growth factor (PlGF) is a dimeric growth factor in the PDGF/VEGF family. Alternative splicing generates at least three human PlGF isoforms PlGF 1, PlGF 2, and PlGF 3. PlGF 2 is the only isoform that contains a heparin binding region. It is expressed by villous trophoblasts, decidual cells, erythroblasts, keratinocytes, and some endothelial cells. PlGF competes with VEGF for binding and activating VEGF R1/Flt 1. This results in increased angiogenesis by making more VEGF available for activation of VEGF R2. PlGF 2 also exhibits heparin dependent binding of Neuropilins-1 and 2 which serve as VEGF co-receptors. It can inhibit nerve growth cone collapse and induce monocyte production of inflammatory cytokines including VEGF.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for PlGF-2 (MP200)(17)

Publications using MP200

• Yang, Z;Jia, X;Deng, Q;Luo, M;Hou, Y;Yue, J;Mei, J;Shan, N;Wu, Z; Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/?-catenin signaling to alleviate preeclampsia International immunopharmacology 2023-02-01 [PMID: 37724958] (Mouse)
• T Mashima, T Wakatsuki, N Kawata, MK Jang, A Nagamori, H Yoshida, K Nakamura, T Migita, H Seimiya, K Yamaguchi Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo Scientific Reports, 2021-07-23;11(1):15125. 2021-07-23 [PMID: 34302038] (Mouse)
• M Jones-Muha, Q Shao, L Cain-Shiel, JP Shaffery, JP Warrington Acid Sensing Ion Channel 2a Is Reduced in the Reduced Uterine Perfusion Pressure Mouse Model and Increases Seizure Susceptibility in Pregnant Mice Cells, 2021-05-08;10(5):. 2021-05-08 [PMID: 34066660] (Mouse)
• FT Spradley High-fat diet from parental generation exaggerates body and adipose tissue weights in pregnant offspring PLoS ONE, 2020-08-20;15(8):e0237708. 2020-08-20 [PMID: 32817646] (Rat)
• FT Spradley, Y Ge, BP Haynes, JP Granger, CD Anderson Adrenergic receptor blockade attenuates placental ischemia-induced hypertension Physiol Rep, 2018-09-01;6(17):e13814. 2018-09-01 [PMID: 30229567] (Rat)
• M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695634] (Mouse)
• F Pognan, JA Mahl, M Papoutsi, D Ledieu, M Raccuglia, D Theil, SB Voytek, PJ Devine, K Kubek-Luck, N Claudio, A Cordier, A Heier, C Kolly, A Hartmann, SD Chibout, P Bouchard, C Trendelenb Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human Arch. Toxicol., 2018-03-19;0(0):. 2018-03-19 [PMID: 29556671] (Mouse, Rat)
• JM Gu, S Yuan, D Sim, K Abe, P Liu, M Rosenbruch, P Bringmann, K Kauser Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease Exp. Hematol., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337222] (Mouse)
• Oladipupo SS, Hu S, Santeford AC, Yao J, Kovalski JR, Shohet RV, Maslov K, Wang LV, Arbeit JM Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. Blood, 2011-02-09;117(15):4142-53. 2011-02-09 [PMID: 21307392] (Human, Mouse)
• Jaffe IZ, Newfell BG, Aronovitz M Placental growth factor mediates aldosterone-dependent vascular injury in mice. J. Clin. Invest., 2010-11-01;120(11):3891-900. 2010-11-01 [PMID: 20921624] (Mouse)
• Wang C, Duan H, He L Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro. Eur. J. Pharmacol., 2009-04-06;612(1):143-52. 2009-04-06 [PMID: 19356732] (Mouse)
• Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Blood, 2007-11-27;111(4):1980-8. 2007-11-27 [PMID: 18042800] (Mouse)
• Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74. 2007-10-17 [PMID: 17942672] (Mouse)
• Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am. J. Pathol., 2006-10-01;169(4):1167-82. 2006-10-01 [PMID: 17003476] (Mouse)
• Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes, 2006-10-01;55(10):2698-704. 2006-10-01 [PMID: 17003333] (Mouse)
• Jensen KK, Manfra DJ, Grisotto MG, Martin AP, Vassileva G, Kelley K, Schwartz TW, Lira SA The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J. Immunol., 2005-03-15;174(6):3686-94. 2005-03-15 [PMID: 15749907] (Mouse)
• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Mouse)

Bioinformatics

• Gene Symbol: Pgf