Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit

Product Discontinued

Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse/Rat/Porcine/Canine TGF-beta 1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TGF-beta 1 in acid activated cell culture supernates, serum, and plasma. It contains recombinant TGF-beta 1 expressed by CHO cells and has been shown to quantitate the recombinant factor accurately. Results obtained using natural TGF-beta 1 showed linear curves that were paralle...l to the standard curves obtained using the recombinant kit standards. These results indicate that this kit will provide accurate quantitation for both recombinant and natural TGF-beta 1.
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• Additional Information: Product is in the process of discontinuation. A replacement product will be available soon.
• Specificity: Natural and recombinant TGF-beta 1. This kit also recognizes human TGF-beta 1.2.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tgfb1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit

• CEDLAP
• DPD1
• latency-associated peptide
• TGF beta
• TGF beta1
• TGFB
• TGFB1
• TGF-beta 1 protein
• TGFbeta 1
• TGF-beta 1
• TGFbeta
• TGF-beta-1
• transforming growth factor beta-1
• transforming growth factor, beta 1

Background

Transforming growth factor beta (TGF-beta ) proteins (including the three closely related mammalian isoforms TGF-beta 1, -2 and -3) are pleiotropic cytokines that regulate extracellular matrix production, wound healing, immune functions, cell proliferation and differentiation. They belong to the large TGF-beta superfamily, which also includes the activins/inhibins/MIS, bone morphogenetic proteins (BMPs), growth/differentiation factors (GDFs), Lefty1 and 2, and the distantly related GDNF family of neurotrophic factors. All family members show a characteristic cysteine-knot that is formed from multiple intrachain disulfide bonds (1-3). 

The mouse, rat, porcine and canine TGF-beta 1 cDNAs encode a 390 amino acid (aa) residue precursor that contains a 29 aa signal peptide and a 361 aa pro-protein. The pro-protein for each species is proteolytically processed via a furin-like convertase to generate an N-terminal 249 aa latency-associated peptide (LAP), and a C-terminal 112 aa mature TGF-beta 1 (4-9). Both LAP and mature TGF-beta 1 exist as disulfide-linked homodimers. After proteolytic cleavage and secretion, the two homodimers remain non-covalently associated as the small latent TGF-beta 1 complex. In most cell types, this complex is also covalently linked via LAP to a latent TGF-beta binding protein (LTBP). This creates a secreted, large latent complex. The TGF-beta 1 present in either the small or the large latent complex is not available for TGF-beta receptor binding and activation, and is, therefore, latent. Whereas LAP is both necessary and sufficient to confer latency to TGF-beta 1, LTBP facilitates the proper folding and secretion of the small latent complex. LTBP is also a structural component of the extracellular matrix and directs the localization of the latent complex to the extracellular matrix (10-15). To date, four LTBPs that share multiple EGF-like, LTBP- and fibrillin-specific domains have been cloned. Three of the four LTBPs (#1, 3, and 4) have been shown to bind the small latent complexes of all TGF-beta isoforms (16). Activation of the latent TGF-beta complex is an important step that regulates TGF-beta function in vivo. Multiple activation mechanisms have been identified. These involve proteasedependent (plasmin and matrix metalloprotease) and protease-independent (binding of LAP to thrombospondin 1 or a subset of integrins) pathways (5, 15, 17-21). Mature mouse TGF-beta 1 shows 100% aa sequence identity to mature rat TGF-beta 1 (6, 7), and both rat and mouse TGF-beta 1 show 99% aa sequence identity with mature porcine, human, and canine TGF-beta 1 (4, 9, 22). Mature porcine TGF-beta 1 shows absolute identity to both mature human and canine TGF-beta 1. 

The signalling high-affinity receptor for TGF-beta 1 is a heteromeric complex consisting of a type I (TGF-beta RI) and a type II (TGF-beta RII) transmembrane serine/threonine kinase receptor. TGF-beta RII is a constitutively active kinase. Upon binding TGF-beta 1, it phosphorylates and activates the TGF-beta RI. In turn, TGF-beta RI phosphorylates and activates Smad proteins that regulate transcription. TGF-beta RI, alternatively named activin receptor-like kinase (ALK-5), is present in almost all cell types. Two other type I receptors, ALK-1 and ALK-2 have also been implicated as alternative partners for TGF-beta RII in the TGF-beta signalling receptor complex. Besides the type I and type II receptors, accessory receptors including the type III receptor, TGF-beta RIII (also known as betaglycan), and endoglin, which modulate TGF-beta responses, have been identified (2, 23-26).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TGF-beta 1 (MB100B)(243)

Publications using MB100B

• Zhuang, Z;Liu, A;Zhang, J;Han, S;Tang, L;Yu, T;Shi, Y;Li, H;Yang, H;Bai, P;Tang, Y; Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition Journal of translational medicine 2024-10-31 [PMID: 39482719] (Mouse)
• Zheng, Z;Lin, X;Zhao, Z;Lin, Q;Liu, J;Chen, M;Wu, W;Wu, Z;Liu, N;Chen, H; A vascular endothelial growth factor-loaded chitosanhyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke Neural regeneration research 2024-09-06 [PMID: 39248177] (Rat)
• SY Heazlewood, T Ahmad, B Cao, H Cao, M Domingues, X Sun, CK Heazlewood, S Li, B Williams, M Fulton, JF White, T Nebl, CM Nefzger, JM Polo, BT Kile, F Kraus, MT Ryan, YB Sun, PFM Choong, SL Ellis, ML Anko, SK Nilsson High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production Nature Communications, 2023-04-13;14(1):2099. 2023-04-13 [PMID: 37055407] (Mouse)
• DAG Mázala, R Hindupur, YJ Moon, F Shaikh, IH Gamu, D Alladi, G Panci, M Weiss-Gaye, B Chazaud, TA Partridge, JS Novak, JK Jaiswal Altered muscle niche contributes to myogenic deficit in the D2- mdx model of severe DMD bioRxiv : the preprint server for biology, 2023-03-28;0(0):. 2023-03-28 [PMID: 37034785] (Mouse)
• M Teunissen, BP Meij, L Snel, K Coeleveld, J Popov-Cele, IS Ludwig, F Broere, FPJG Lafeber, MA Tryfonidou, SC Mastbergen The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period Journal of Orthopaedic Translation, 2022-10-20;38(0):44-55. 2022-10-20 [PMID: 36313973] (Canine)
• B Strobel, H Klein, G Leparc, BE Stierstorf, F Gantner, S Kreuz Time and phenotype-dependent transcriptome analysis in AAV-TGFbeta1 and Bleomycin-induced lung fibrosis models Scientific Reports, 2022-07-16;12(1):12190. 2022-07-16 [PMID: 35842487] (Mouse)
• H Wu, H Li, Y Liu, J Liang, Q Liu, Z Xu, Z Chen, X Zhang, K Zhang, C Xu Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy Bioactive materials, 2021-11-03;13(0):223-238. 2021-11-03 [PMID: 35224304] (Mouse)
• M Popek, B Bobula, K Orze?-Gajo, M Zieli?ska The Effect of TGF-beta1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy International Journal of Molecular Sciences, 2022-01-19;23(3):. 2022-01-19 [PMID: 35163004] (Mouse)
• CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3 JCI Insight, 2022-02-08;0(0):. 2022-02-08 [PMID: 34941574] (Mouse)
• A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis Nature Communications, 2021-10-12;12(1):5947. 2021-10-12 [PMID: 34642338] (Mouse)
• QR Li, SR Tan, L Yang, W He, L Chen, FX Shen, Z Wang, HF Wang Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae-induced pneumonia Journal of leukocyte biology, 2021-09-29;0(0):. 2021-09-29 [PMID: 34585429] (Mouse)
• S Wang, C Tang, H Zhao, P Shen, C Lin, Y Zhu, D Han Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis Frontiers in Pharmacology, 2021-07-01;12(0):656115. 2021-07-01 [PMID: 34276360] (Mouse)
• D Vanhoutte, TG Schips, A Vo, KM Grimes, TA Baldwin, MJ Brody, F Accornero, MA Sargent, JD Molkentin Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy Nature Communications, 2021-06-24;12(1):3928. 2021-06-24 [PMID: 34168130] (Mouse)
• W Wei, W Chen, N He HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation Journal of Translational Medicine, 2021-06-12;19(1):258. 2021-06-12 [PMID: 34118928] (Mouse)
• I Belinchón-, P Bellot, D Romero-Pér, I Herraiz-Ro, F Marco, R Frances, JM Ramos-Rinc Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients Scientific Reports, 2021-04-21;11(1):8593. 2021-04-21 [PMID: 33883616] (Rat)
• LT Wang, MH Lin, KY Liu, SS Chiou, SN Wang, CY Chai, LW Tseng, HC Chiou, HC Wang, KK Yokoyama, SH Hsu, SK Huang WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism Autophagy, 2021-04-14;0(0):1-16. 2021-04-14 [PMID: 33853474] (Mouse)
• CK Lin, TH Huang, CT Yang, CS Shi Roles of lung-recruited monocytes and pulmonary Vascular Endothelial Growth Factor (VEGF) in resolving Ventilator-Induced Lung Injury (VILI) PLoS ONE, 2021-03-19;16(3):e0248959. 2021-03-19 [PMID: 33740009] (Mouse)
• AA Hastreiter, GG Dos Santos, EN Makiyama, EWC Santos, P Borelli, RA Fock Effects of protein malnutrition on haematopoietic regulatory activity of bone marrow mesenchymal stem cells The Journal of nutritional biochemistry, 2021-03-08;0(0):108626. 2021-03-08 [PMID: 33705953] (Mouse)
• Q Liang, Q Lin, Y Li, W Luo, X Huang, Y Jiang, C Qin, J Nong, X Chen, SR Sooranna, L Pinhu Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model Journal of Immunology Research, 2020-11-25;2020(0):6644687. 2020-11-25 [PMID: 33294466] (Rat)
• D Ponikwicka, M Chrusciel, K Pulawska, P Bernaczyk, M Sztachelsk, P Guo, X Li, J Toppari, IT Huhtaniemi, S Wo?czy?ski, NA Rahman Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice Cancers (Basel), 2020-11-04;12(11):. 2020-11-04 [PMID: 33158280] (Mouse)
• M Kato, F Takahashi, T Sato, Y Mitsuishi, K Tajima, H Ihara, F Nurwidya, H Baskoro, A Murakami, I Kobayashi, M Hidayat, N Shimada, S Sasaki, R Mineki, T Fujimura, T Kumasaka, SI Niwa, K Takahashi Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGF&beta/SMAD2 Pathway Drug Des Devel Ther, 2020-10-29;14(0):4593-4603. 2020-10-29 [PMID: 33149556] (Mouse)
• N Hagan, JL Kane, D Grover, L Woodworth, C Madore, J Saleh, J Sancho, J Liu, Y Li, J Proto, M Zelic, A Mahan, M Kothe, AA Scholte, M Fitzgerald, B Gisevius, A Haghikia, O Butovsky, D Ofengeim CSF1R signaling is a regulator of pathogenesis in progressive MS Cell Death Dis, 2020-10-23;11(10):904. 2020-10-23 [PMID: 33097690] (Mouse)
• W El Bakly, M Medhat, M Shafei, R Tash, M Elrefai, Y Shoukry, NN Omar Optimized platelet rich plasma releasate (O-rPRP) repairs galactosemia-induced ovarian follicular loss in rats by activating mTOR signaling and inhibiting apoptosis Heliyon, 2020-09-21;6(9):e05006. 2020-09-21 [PMID: 33005806] (Rat)
• S Valletta, A Thomas, Y Meng, X Ren, R Drissen, H Sengül, C Di Genua, C Nerlov Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFbeta1 as regulators of hematopoietic ageing Nat Commun, 2020-08-14;11(1):4075. 2020-08-14 [PMID: 32796847] (Mouse)
• L Zhang, H Peng, W Zhang, Y Li, L Liu, T Leng Yeast Cell wall Particle mediated Nanotube-RNA delivery system loaded with miR365 Antagomir for Post-traumatic Osteoarthritis Therapy via Oral Route Theranostics, 2020-07-09;10(19):8479-8493. 2020-07-09 [PMID: 32754258] (Mouse)
• Y Liu, R Bockermann, M Hadi, I Safari, B Carrion, M Kveiborg, S Issazadeh- ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation Cell. Mol. Immunol., 2020-06-22;0(0):. 2020-06-22 [PMID: 32572163] (Mouse)
• J Banga, D Srinivasan, CC Sun, CD Thompson, F Milletti, KS Huang, S Hamilton, S Song, AF Hoffman, YG Qin, B Matta, M LaPan, Q Guo, G Lu, D Li, H Qian, DR Bolin, L Liang, C Wartchow, J Qiu, M Downing, S Narula, N Fotouhi, JA DeMartino, SL Tan, G Chen, BJ Barnes Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization Sci Adv, 2020-05-15;6(20):eaay1057. 2020-05-15 [PMID: 32440537] (Human)
• R Kulshresth, A Pandey, A Jaggi, S Bansal Beneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats Iran J Basic Med Sci, 2020-03-01;23(3):396-405. 2020-03-01 [PMID: 32440328] (Rat)
• R Wang, K Huang CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL?2 and TGF?&beta by CD4+ T�cells via the STAT5 signaling pathway Mol Med Rep, 2020-04-01;0(0):. 2020-04-01 [PMID: 32323817] (Mouse)
• S Tsuji, E Di Martino, T Mukai, S Tsuji, T Murakami, RA Harris, K Blomgren, U Åden Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice J Neuroinflammation, 2020-04-11;17(1):111. 2020-04-11 [PMID: 32276642] (Mouse)
• DA Mázala, JS Novak, MW Hogarth, M Nearing, P Adusumalli, CB Tully, NF Habib, H Gordish-Dr, YW Chen, JK Jaiswal, TA Partridge TGF-&beta-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model JCI Insight, 2020-03-26;5(6):. 2020-03-26 [PMID: 32213706] (Mouse)
• DM Karageorgi, DI Tsilimigra, P Selemenaki, V Vlachou, AL de Lastic, M Rodi, D Chatziatha, K Savvatakis, N Antoniou, AC Deli, A Papalampro, KA Filis, A Mouzaki, A Varvarigou, G Zografos, VG Gorgoulis, IS Pateras, F Sigala Conditioning attenuates kidney and heart injury in rats following transient suprarenal occlusion of the abdominal aorta Sci Rep, 2020-03-19;10(1):5040. 2020-03-19 [PMID: 32193441] (Rat)
• HC Tsai, CF Hsu, CC Huang, SF Huang, TH Li, YY Yang, MW Lin, TY Lee, CW Liu, YH Huang, MC Hou, HC Lin Propranolol Suppresses the T-Helper Cell Depletion-Related Immune Dysfunction in Cirrhotic Mice Cells, 2020-03-03;9(3):. 2020-03-03 [PMID: 32138352] (Mouse)
• G Cohen, P Chandran, RM Lorsung, LE Tomlinson, M Sundby, SR Burks, JA Frank The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response Cancers (Basel), 2020-02-04;12(2):. 2020-02-04 [PMID: 32033171] (Mouse)
• C Kornsuthis, N Pirarat, T Osathanon, C Kalpravidh Autologous platelet-rich fibrin stimulates canine periodontal regeneration Sci Rep, 2020-02-05;10(1):1850. 2020-02-05 [PMID: 32024893] (Canine)
• A Oppezzo, J Bourseguin, E Renaud, P Pawlikowsk, F Rosselli Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia J. Clin. Invest., 2020-03-02;0(0):. 2020-03-02 [PMID: 31877112] (Mouse)
• E Picarda, S Bézie, L Usero, J Ossart, M Besnard, H Halim, K Echasserie, C Usal, J Rossjohn, K Bernardeau, S Gras, C Guillonnea Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection Cell Rep, 2019-12-24;29(13):4245-4255.e6. 2019-12-24 [PMID: 31875536] (Human, Rat)
• N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation Sci Rep, 2019-11-26;9(1):17558. 2019-11-26 [PMID: 31772282] (Mouse)
• JL Zhao, T Zhang, X Shao, JJ Zhu, MZ Guo Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis BMC Complement Altern Med, 2019-10-23;19(1):280. 2019-10-23 [PMID: 31647008] (Rat)
• W Hu, L Ma, G Yang, X Zeng, J Liu, B Cheng, T Hu, H Zhao, Z Liu Der p2?A20 DNA vaccine attenuates allergic inflammation in mice with allergic rhinitis Mol Med Rep, 2019-10-21;0(0):. 2019-10-21 [PMID: 31638224] (Mouse)
• SV Hudson, HA Miller, GE Mahlbacher, D Saforo, LJ Beverly, GE Arteel, HB Frieboes Computational/experimental evaluation of liver metastasis post hepatic injury: interactions with macrophages and transitional ECM Sci Rep, 2019-10-21;9(1):15077. 2019-10-21 [PMID: 31636296] (Mouse)
• H Wang, J Shen, Y Pi, K Gao, W Zhu Low-protein diets supplemented with casein hydrolysate favor the microbiota and enhance the mucosal humoral immunity in the colon of pigs J Anim Sci Biotechnol, 2019-10-10;10(0):79. 2019-10-10 [PMID: 31624591] (Porcine)
• YZ Zhou, Z Cheng, Y Wu, QY Wu, XB Liao, Y Zhao, JM Li, XM Zhou, XM Fu Mesenchymal stem cell-derived conditioned medium attenuate angiotensin II-induced aortic aneurysm growth by modulating macrophage polarization J. Cell. Mol. Med., 2019-10-04;0(0):. 2019-10-04 [PMID: 31583844] (Mouse)
• M Haloul, ERA Oliveira, M Kader, JZ Wells, TR Tominello, A El Andalou, CC Yates, N Ismail mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis Sci Rep, 2019-10-01;9(1):14050. 2019-10-01 [PMID: 31575880] (Mouse)
• B Wu, XY Huang, L Li, XH Fan, PC Li, CQ Huang, J Xiao, R Gui, S Wang Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model J. Cell. Mol. Med., 2019-09-29;0(0):. 2019-09-29 [PMID: 31565849] (Rat)
• XH Yu, YF Wang, FY Dai, JH Zhao, P Li The protective effects of Berberine and Hesperidin on inflammatory factor-stimulating cardiac fibroblasts Eur Rev Med Pharmacol Sci, 2019-06-01;23(12):5468-5476. 2019-06-01 [PMID: 31298400] (Rat)
• A Tripathi, B Kumar, SSK Sagi Prophylactic efficacy of Quercetin in ameliorating the hypoxia induced vascular leakage in lungs of rats PLoS ONE, 2019-06-28;14(6):e0219075. 2019-06-28 [PMID: 31251771] (Rat)
• M Liang, Q Ma, N Ding, F Luo, Y Bai, F Kang, X Gong, R Dong, J Dai, Q Dai, C Dou, S Dong IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis Cell Death Dis, 2019-04-30;10(5):353. 2019-04-30 [PMID: 31040267] (Mouse)
• HY Yang, KS Kim, YH Lee, JH Park, JH Kim, SY Lee, YM Kim, IS Kim, S Kacew, BM Lee, JH Kwak, K Yoon, HS Kim Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-?1/Smads Pathways Int. J. Biol. Sci., 2019-02-13;15(4):800-811. 2019-02-13 [PMID: 30906211] (Rat)
• S Liang, J Cai, Y Li, R Yang 1,25?Dihydroxy?Vitamin D3 induces macrophage polarization to M2 by upregulating T?cell Ig?mucin?3 expression Mol Med Rep, 2019-03-15;0(0):. 2019-03-15 [PMID: 30896850] (Mouse)
• Z Li, Y Lin, S Zhang, L Zhou, G Yan, Y Wang, M Zhang, M Wang, H Lin, Q Tong, Y Duan, G Du Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis J Transl Med, 2019-03-18;17(1):90. 2019-03-18 [PMID: 30885207] (Mouse)
• WD Chen, JL Zhang, XY Wang, ZW Hu, YB Qian The JAK2/STAT3 signaling pathway is required for inflammation and cell death induced by cerulein in AR42J cells Eur Rev Med Pharmacol Sci, 2019-02-01;23(4):1770-1777. 2019-02-01 [PMID: 30840302] (Rat)
• R Gater, T Ipek, S Sadiq, D Nguyen, L Jones, A El Haj, Y Yang Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model Invest. Ophthalmol. Vis. Sci., 2019-02-01;60(2):605-614. 2019-02-01 [PMID: 30726503] (Porcine)
• NM El-Lakkany, WH El-Maadawy, SH Seif El-Di, S Saleh, MM Safar, SM Ezzat, SH Mohamed, SS Botros, Z Demerdash, OA Hammam Antifibrotic effects of gallic acid on hepatic stellate cells: In�vitro and in�vivo mechanistic study J Tradit Complement Med, 2018-04-27;9(1):45-53. 2018-04-27 [PMID: 30671365] (Rat)
• MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression Exp. Mol. Med., 2018-11-05;50(11):142. 2018-11-05 [PMID: 30393382] (Mouse)
• LC Dutton, J Dudhia, B Catchpole, H Hodgkiss-G, D Werling, DJ Connolly Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor Sci Rep, 2018-09-06;8(1):13351. 2018-09-06 [PMID: 30190508] (Canine)
• S Bang, YK Xie, ZJ Zhang, Z Wang, ZZ Xu, RR Ji GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain J. Clin. Invest., 2018-07-16;128(8):3568-3582. 2018-07-16 [PMID: 30010619] (Mouse)
• CS Chiang, JY Chen, MY Chiang, KT Hou, WM Li, SJ Chang, SY Chen Using the interplay of magnetic guidance and controlled TGF-? release from protein-based nanocapsules to stimulate chondrogenesis Int J Nanomedicine, 2018-06-07;13(0):3177-3188. 2018-06-07 [PMID: 29922054] (Mouse)
• K Schlereth, D Weichenhan, T Bauer, T Heumann, E Giannakour, D Lipka, S Jaeger, M Schlesner, P Aloy, R Eils, C Plass, HG Augustin The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium Elife, 2018-05-11;7(0):. 2018-05-11 [PMID: 29749927] (Mouse)
• M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695634] (Mouse)
• L Jiang, X Han, J Wang, C Wang, X Sun, J Xie, G Wu, H Phan, Z Liu, C Zhang, M Zhao, X Kang SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling J. Exp. Med., 2018-04-18;0(0):. 2018-04-18 [PMID: 29669741] (Mouse)
• P Ayala, J Torres, R Vivar, M Meneses, P Olmos, T San Martin, GR Borzone Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution Respir. Res., 2018-04-10;19(1):57. 2018-04-10 [PMID: 29631627] (Mouse)
• Y Gu, G Srimathvee, L Cai, E Ueshima, M Maybody, H Yarmohamma, YS Zhu, JC Durack, SB Solomon, JA Coleman, JP Erinjeri Pirfenidone inhibits cryoablation induced local macrophage infiltration along with its associated TGFb1 expression and serum cytokine level in a mouse model Cryobiology, 2018-04-03;0(0):. 2018-04-03 [PMID: 29621494] (Mouse)
• H Wu, X Xu, J Li, J Gong, M Li TIM?4 blockade of KCs combined with exogenous TGF?β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts Int. J. Mol. Med., 2018-03-30;0(0):. 2018-03-30 [PMID: 29620252] (Mouse)
• F Mayyas, R Jaradat, KH Alzoubi Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes Nutr Metab Cardiovasc Dis, 2018-02-25;0(0):. 2018-02-25 [PMID: 29615288] (Rat)
• B Zhao, M Hu, H Wu, C Ren, J Chen, X Zhang, S Cui Peroxisome proliferator-activated receptor-? and its related pathway in bone marrow mesenchymal stem cell differentiation co-cultured with mechanically stretched ligament fibroblasts Int. J. Mol. Med., 2018-03-20;0(0):. 2018-03-20 [PMID: 29568896] (Rat)
• Y Okada, T Wang, K Kasai, K Suzuki, Y Takikawa Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma Cell Death Discov, 2018-03-12;4(0):42. 2018-03-12 [PMID: 29560281] (Mouse)
• F da Silva L, AB da Rocha R, A Hastreiter, A Nogueira-P, E Makiyama, C Colli, RA Fock An insight into the role of magnesium in the immunomodulatory properties of mesenchymal stem cells J. Nutr. Biochem., 2018-02-13;55(0):200-208. 2018-02-13 [PMID: 29554498] (Mouse)
• JD Koerner, DZ Markova, GD Schroeder, BP Calio, A Shah, CW Brooks, AR Vaccaro, DG Anderson, CK Kepler The local cytokine and growth factor response to rhBMP-2 after spinal fusion Spine J, 2018-03-14;0(0):. 2018-03-14 [PMID: 29550606] (ELISA (Standard), Rat)
• T Niwa, Y Yamakoshi, H Yamazaki, T Karakida, R Chiba, JC Hu, T Nagano, R Yamamoto, JP Simmer, HC Margolis, K Gomi The dynamics of TGF-? in dental pulp, odontoblasts and dentin Sci Rep, 2018-03-13;8(1):4450. 2018-03-13 [PMID: 29535349] (Mouse)
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• Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am. J. Respir. Crit. Care Med., 2004-04-22;170(2):188-94. 2004-04-22 [PMID: 15105163] (Rat)
• Blum B, Moseley J, Miller L, Richelsoph K, Haggard W Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix. Orthopedics, 2004-01-01;27(1):161-5. 2004-01-01 [PMID: 14763551] (Human)
• Kobayashi T, Iijima K, Kita H Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. J. Immunol., 2003-06-01;170(11):5756-63. 2003-06-01 [PMID: 12759459] (Mouse)

Bioinformatics

• Gene Symbol: Tgfb1