Nurr1/NGFI-B beta/NR4A2 Antibody (N1404) [Unconjugated]

Product Discontinued

Nurr1/NGFI-B beta/NR4A2 Antibody (N1404) [Unconjugated] Summary

• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: NR4A2

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5-15 ug/mL
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Buffer: A liquid formulation in physiologic saline with 0.1% NaN₃.
• Preservative: 0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Nurr1/NGFI-B beta/NR4A2 Antibody (N1404) [Unconjugated]

• human homolog of
• NGFI-B beta
• NOT
• NR4A2
• nuclear receptor subfamily 4, group A, member 2
• Nurr1
• orphan nuclear receptor NR4A2
• Orphan nuclear receptor NURR1
• T-cell nuclear receptor NOT
• TINUR
• transcriptionally inducible nuclear receptor related 1
• Transcriptionally-inducible nuclear receptor

Background

Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr 1 is important for specification of dopaminergic neurons that degenerate in Parkinsons disease. Human and mouse Nurr1 share 99% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Nurr1/NGFI-B beta/NR4A2 Antibody (PP-N1404-00)(2)

Publications using PP-N1404-00

• Kojima, R;Paslawski, W;Lyu, G;Arenas, E;Zhang, X;Svenningsson, P; Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations International journal of molecular sciences 2024-01-04 [PMID: 38203854] (Immunocytochemistry, Human)
• Li Y, Ohashi R, Naito M Expression of the nerve growth factor-induced gene B-beta in the developing rat brain and retina. Arch. Histol. Cytol., 2009-03-01;72(1):23-34. 2009-03-01 [PMID: 19789410] (IHC-P, Western Blot, Human, Rat)

Bioinformatics

• Gene Symbol: NR4A2