p63/TP73L Antibody (CL3748) - BSA Free

Western Blot: p63/TP73L Antibody (CL3748) [NBP3-05501] - Analysis in human cell line RT-4 and human cell line U-251 MG.

Immunohistochemistry-Paraffin: p63/TP73L Antibody (CL3748) [NBP3-05501] - Staining of human prostate shows nuclear immunoreactivity in basal epithelial cells.

Immunohistochemistry-Paraffin: p63/TP73L Antibody (CL3748) [NBP3-05501] - Staining of human cervix shows strong nuclear immunoreactivity in epithelial cells.

Immunohistochemistry-Paraffin: p63/TP73L Antibody (CL3748) [NBP3-05501] - Staining of human liver shows absence of immunoreactivity (negative control).

Immunohistochemistry-Paraffin: p63/TP73L Antibody (CL3748) [NBP3-05501] - Staining of human lung cancer (adenocarcinoma) shows absence of immunoreactivity (negative control).

Immunohistochemistry-Paraffin: p63/TP73L Antibody (CL3748) [NBP3-05501] - Staining of human placenta shows nuclear positivity in a subset of cells.

Immunohistochemistry-Paraffin: p63/TP73L Antibody (CL3748) [NBP3-05501] - Staining of human prostate cancer shows absence of nuclear immunoreactivity in tumor cells, while it is present in the adjacent normal a basal epithelial cells.

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: CL3748
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

p63/TP73L Antibody (CL3748) - BSA Free Summary

• Immunogen: This antibody was developed using a recombinant protein derived from Q9H3D4, with the exact immunogen sequence remaining proprietary.
• Predicted Species: Mouse (99%), Rat (94%). Backed by our 100% Guarantee.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TP63
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
  • Western Blot 1 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.2, containing 40% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Protein A purified

Alternate Names for p63/TP73L Antibody (CL3748) - BSA Free

• amplified in squamous cell carcinoma
• Chronic ulcerative stomatitis protein
• CUSP
• EEC3
• EEC3B(p51B)
• Keratinocyte transcription factor KET
• KET
• KETRHS
• LMS
• OFC8
• OFC8SHFM4TP73LNBP
• p40
• p51
• p51tumor protein p53-like
• p53CP
• p63
• p63AIS
• p73H
• p73L
• p73LB(p51A)
• SHFM4
• TP53CP
• TP53L
• TP63
• TP73L
• Transformation-related protein 63
• tumor protein 63
• tumor protein p53-competing protein
• tumor protein p63 deltaN isoform delta
• tumor protein p63
• Tumor protein p73-like

Background

The p63 gene, a homologue of the tumor suppressor p53, is highly expressed in the basal or progenitor layers of many epithelial tissues. P63 shows remarkable structural similarity to p53 and to the related p73 gene. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TP63